期刊
ORGANIC LETTERS
卷 10, 期 22, 页码 5187-5190出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol802159v
关键词
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资金
- NSF
- Merck
- ACS PRF [43905-G1]
- NMR
Au-catalyzed synthesis of 5,6-dihydro-8H-indolizin-7-ones from readily available N-(pent-2-en-4-ynyl)-beta-lactams is developed. In this reaction, a 5-exo-dig cyclization of the beta-lactam nitrogen to the Au-activated C-C triple bond is followed by heterolytic fragmentation of the amide bond, forming a highly nucleophilic acyl cation. An expedient formal synthesis of indolizidine 167B was easily achieved using this new method.
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