Article
Immunology
Yi Zhai, Yanli Pang
Summary: PCOS is a common disorder related to endocrine/reproductive/metabolic systems, and it is associated with low-grade chronic inflammation. Patients with PCOS have higher levels of inflammatory cells and factors, as well as lower levels of anti-inflammatory cytokines. This systemic inflammation is thought to interact with obesity, insulin resistance, and hyperandrogenism.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Shaimaa Aboeldalyl, Cathryn James, Emaduldin Seyam, Emad Moussa Ibrahim, Hossam El-Din Shawki, Saad Amer
Summary: The study found that circulating CRP levels are moderately elevated in women with PCOS, independent of obesity, indicating the presence of low-grade chronic inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Dan Tian, Wei Chen, Qing Xu, Xiaoyu Li, Qianzhou Lv
Summary: Liraglutide treatment significantly improves waist circumference, BMI, weight, and insulin resistance in obese women with PCOS, with a potential effect on FSH and LH but with high heterogeneity.
Review
Pharmacology & Pharmacy
Congshun Ma, Qianru Xiang, Ge Song, Xuefei Wang
Summary: Polycystic ovary syndrome (PCOS) is a reproductive endocrine disease with no specific drug treatment. Quercetin (QUR), a flavonoid, has potential therapeutic effects for PCOS patients. However, the mechanisms of QUR in PCOS patients remain unclear.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Luigi Barrea, Ludovica Verde, Claudia Vetrani, Annamaria Docimo, Giulia de Alteriis, Silvia Savastano, Annamaria Colao, Giovanna Muscogiuri
Summary: This study investigated the prevalence of different chronotype categories in women with PCOS and their impact on hormonal and metabolic aspects. The findings showed a higher prevalence of evening chronotype in women with PCOS, which was associated with worse hormonal and metabolic profiles.
JOURNAL OF PINEAL RESEARCH
(2023)
Article
Obstetrics & Gynecology
Karen E. Elkind-Hirsch, Neil Chappell, Donna Shaler, John Storment, Drake Bellanger
Summary: This study aimed to evaluate the efficacy and safety of the GLP-1 analog liraglutide 3 mg (LIRA 3 mg) in reducing body weight and hyperandrogenism in women with obesity and polycystic ovary syndrome (PCOS). The results showed that LIRA 3 mg was superior to placebo in reducing body weight, lowering androgen levels, and improving cardiometabolic parameters.
FERTILITY AND STERILITY
(2022)
Review
Multidisciplinary Sciences
Yang Wu, Tao Peng, Yu Chen, Li Huang, Bisong He, Shaobin Wei
Summary: This study aims to evaluate the effectiveness and safety of acupuncture for insulin resistance and lipid metabolic disorder of women with PCOS. Randomized controlled trials (RCTs) of acupuncture therapy for PCOS will be included, data analysis will be conducted independently by two or more reviewers, calculating mean difference (MD), standard mean difference (SMD), and 95% confidence intervals (CIs), and data synthesis will be performed using RevMan V.5.3 software and Stata V.15.0 software when necessary.
Article
Medicine, Research & Experimental
Manuel R. Garcia-Saenz, Miry Lobaton-Ginsberg, Claudia Ramirez-Renteria, Nitzia Lopez-Juarez, Renata Saucedo, Jorge Valencia-Ortega, Aldo Ferreira-Hermosillo
Summary: This study evaluated the clinical and biochemical characteristics of patients with type 1 diabetes (T1D) with and without polycystic ovarian syndrome (PCOS). The results showed a prevalence of 39% for PCOS in T1D patients, and significant differences were found between patients with and without PCOS in terms of insulin usage, glucose levels, ovarian volume, and Ferriman-Gallwey scores. Additionally, PCOS women had a higher incidence of insulin resistance and metabolic syndrome.
ARCHIVES OF MEDICAL RESEARCH
(2023)
Review
Endocrinology & Metabolism
Lucas Bandeira Marchesan, Ramon Bossardi Ramos, Poli Mara Spritzer
Summary: The metabolic profiles of women with PCOS in Latin America are worse than those without PCOS in the same region, with higher anthropometric and metabolic parameters. Further studies evaluating metabolic comorbidities and distinct PCOS phenotypes in different Latin American countries are needed for primary and secondary prevention of PCOS in the region.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Jiayue Liu, Ying Liu, Xiaoliang Li
Summary: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age, characterized by ovulation disorders, high androgen levels, and insulin resistance. The pathogenesis of PCOS is still unclear. Intestinal flora, known as the second genome of human beings, is closely linked to metabolic diseases, immune diseases, and infectious diseases. There is increasing evidence that intestinal flora can regulate insulin synthesis and secretion, affect androgen metabolism and follicular development, and play a role in chronic inflammation and obesity. The imbalance of intestinal flora, related to changes in microbial diversity and interactions with host cells, is associated with the occurrence and development of PCOS. Modulating intestinal flora may offer a potential direction for PCOS treatment.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Medical Laboratory Technology
Huiqing Liu, Xingqi Meng, Jinyuan Wang, Yi Wei, Jinru Tang, Xiaocan Lei, Weiguo He, Suyun Li
Summary: PCOS is an endocrinemetabolic disease affecting reproductive aged women, potentially leading to various complications. Recent studies have identified a protein called SAA that may be associated with PCOS, serving as a potential inflammatory biomarker.
CLINICA CHIMICA ACTA
(2021)
Review
Medicine, General & Internal
Sarantis Livadas, Rodis Paparodis, Panagiotis Anagnostis, Alessandra Gambineri, Jelica Bjekic-Macut, Tijana Petrovic, Bulent O. Yildiz, Dragan Micic, George Mastorakos, Djuro Macut
Summary: Women with polycystic ovary syndrome (PCOS) are at higher risk for dysglycemia and type 2 diabetes compared to healthy BMI-matched women of reproductive age. The incidence of this disorder varies among studies, and there is no consensus on the best screening method and frequency. Universal screening with oral glucose tolerance test is suggested to identify and manage glycemic abnormalities in young women with PCOS, regardless of age or BMI status. Regular follow-up and lifestyle interventions, such as balanced diet and exercise, are important for this specific population.
Article
Endocrinology & Metabolism
Anuradhaa Subramanian, Astha Anand, Nicola J. Adderley, Kelvin Okoth, Konstantinos A. Toulis, Krishna Gokhale, Christopher Sainsbury, Michael W. O'Reilly, Wiebke Arlt, Krishnarajah Nirantharakumar
Summary: The study revealed that women with polycystic ovary syndrome (PCOS) are at an increased risk of COVID-19 infection compared to women without PCOS, with the risk remaining elevated even after adjusting for other variables. Therefore, it is crucial for PCOS patients to adhere to infection control measures during the COVID-19 pandemic.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Plant Sciences
Javad Heshmati, Ashraf Moini, Mahdi Sepidarkish, Mojgan Morvaridzadeh, Masoud Salehi, Andriko Palmowski, Maryam Farid Mojtahedi, Farzad Shidfar
Summary: The study found that using curcumin in PCOS patients can effectively improve blood sugar and androgen levels, and is safe and reliable. Longer trials with different dosages are needed to confirm these findings.
Article
Obstetrics & Gynecology
M. Insenser, A. Quintero, S. de Lope, F. Alvarez-Blasco, M. A. Martinez-Garcia, M. Luque-Ramirez, H. F. Escobar-Morreale
Summary: This research found that the expression of miR-142-3p and miR-598-3p, which are associated with polycystic ovary syndrome (PCOS), differs significantly between women with PCOS and those without. These circulating miRNAs, when combined with easily available measurements such as waist-to-hip ratio (WHR) and circulating LH-to-FSH (LH/FSH) ratios, can effectively distinguish between women with and without PCOS.
HUMAN REPRODUCTION
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Leili Pourafkari, Nader D. Nader
Article
Immunology
Ata Mahmoodpoor, Sarvin Sanaie, Parisa Samadi, Mehdi Yousefi, Nader D. Nader
Summary: The highly infectious coronavirus SARS-CoV-2 emerged in Wuhan, China in November 2019 and has spread globally, leading to significant public health, economic, and social impacts. Efforts have been made to develop safe and effective COVID-19 vaccines, with Pfizer and Moderna's mRNA-based vaccines having received emergency use authorization and showing high efficacy rates. Challenges such as disease enhancement, virus mutations, and public acceptance of the vaccine have been highlighted in vaccine development efforts.
IMMUNOLOGICAL INVESTIGATIONS
(2021)
Review
Pharmacology & Pharmacy
Faegheh Ebrahimi Chaharom, Leili Pourafkari, Ali Asghar Ebrahimi Chaharom, Nader D. Nader
Summary: In Covid-19 patients, corticosteroid therapy may not be effective in reducing mortality, length of hospital stay, likelihood of intubation and mechanical ventilation, and ICU admission.
PULMONARY PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Biochemistry & Molecular Biology
Ayuob Aghanejad, Samad Farashi Bonab, Maryam Sepehri, Fatemeh Sadat Haghighi, Ali Tarighatnia, Christopher Kreiter, Nader D. Nader, Mohammad Reza Tohidkia
Summary: Monoclonal antibodies have been considered a promising tool in cancer therapy and the study of the tumor microenvironment has become increasingly important. Innovative strategies targeting the vasculature system, immune system, stroma-based growth signals, and cancer stem cells have been highlighted as ways to indirectly destroy tumor cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Medicine, Research & Experimental
Jamileh Kadkhoda, Ali Tarighatnia, Mohammad Reza Tohidkia, Nader D. Nader, Ayuob Aghanejad
Summary: This review provides insights into the potential mechanisms of photothermal therapy in breast cancer treatment, particularly through regulating autophagy to induce cell death.
Article
Clinical Neurology
Reza Mohammadian, Ali Tarighatnia, Ehsan Sharifipour, Eskandar Nourizadeh, Rezayat Parvizi, Camille T. Applegate, Nader D. Nader
Summary: This study compared the outcomes of staged carotid artery stenting (CAS) before coronary artery bypass grafting (CABG) in patients with coexisting carotid and coronary artery disease. The results showed that staged CAS had minimal adverse outcomes in these patients.
INTERVENTIONAL NEURORADIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Hassan Javadzadegan, Ahmad Separham, Aidin Farokhi, Camille Applegate, Nader D. Nader
Summary: This study aims to investigate the role of vitamin D2 in the resolution of ST-segment elevation (STE) after a primary percutaneous coronary intervention (PCI) and finds that critically low levels of vitamin D are associated with the absence of resolution in patients.
Editorial Material
Anesthesiology
Robert Lee, Nader D. Nader
JOURNAL OF CLINICAL ANESTHESIA
(2022)
Article
Multidisciplinary Sciences
Kamran Shadvar, Nader Nader-Djalal, Noushin Vahed, Sarvin Sanaie, Afshin Iranpour, Ata Mahmoodpoor, Amir Vahedian-Azimi, Abbas Samim, Farshid Rahimi-Bashar
Summary: This study evaluated the prognostic value of the Lactate to Albumin (L/A) ratio compared to lactate and lactate clearance in predicting outcomes in patients with septic shock. The results showed that lactate clearance at 24 hours had the best predictive value for mortality, while the L/A ratio had better predictive value for renal replacement therapy, ICU length of stay, and duration of mechanical ventilation compared to serum lactate and lactate clearance.
SCIENTIFIC REPORTS
(2022)
Article
Anesthesiology
Zachary A. Haas, Cheng Qian, Matthew A. Dabski, Samira Jafarisis, Jonathan Cousins, Stanley F. Fernandez, Nader D. Nader
Summary: The authors aimed to examine the level of agreement between the contrast and noncontrast methods of aortic valve sizing during intraoperative transesophageal echocardiography (TEE). The results showed that the aortic valve area was overestimated by 0.26 cm2 and the peak and mean aortic valve gradients were underestimated by 19 and 11 mmHg, respectively, when measurements were done without using contrast agent. Using a contrast agent improved the accuracy of measurements and made them comparable to those obtained by transthoracic echocardiography (TTE).
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2023)
Correction
Clinical Neurology
S. H. R. Faiz, N. D. Nader, S. Niknejadi, S. Davari-Farid, G. G. Hobika, P. Rahimzadeh
JOURNAL OF PAIN RESEARCH
(2023)
Article
Immunology
Faegheh Ebrahimi Chaharom, Ali Asghar Ebrahimi, Faroogh Feghhi Koochebagh, Zohreh Babalou, Morteza Ghojazadeh, Leili Aghebati Maleki, Nader D. Nader
Summary: The study investigates the relationship between serum IL-17 levels and disease activity index in SLE patients. It finds that serum IL-17 is higher in SLE patients compared to healthy individuals, and it correlates positively with disease activity index and organ involvement, especially in renal and nervous system involvement.
IMMUNOLOGICAL MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Ali Tarighatnia, Behrouz Foroughi-Nia, Nader D. Nader, Ayuob Aghanejad
Summary: Nanotechnology has emerged as a promising approach for cancer diagnosis and treatment, offering improved targeting and bioavailability of therapies. This review explores the recent advances in nanosystems and their potential use for image-guided cancer treatment, highlighting the encapsulation of tyrosine kinase inhibitors for diagnosis and monitoring of various types of cancers.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Siavash Sedghi, Wiam Z. Khadra, Leili Pourafkari, Paul R. Knight, Faraz A. Alderson, Nader D. Nader
Summary: The study found that volatile anesthetics can reduce cell necrosis and apoptosis, while the sulfonylurea drug has no effect on it. In addition, volatile anesthetics can reduce caspase-3 activity induced by hydrogen peroxide.
JOURNAL OF CARDIOVASCULAR AND THORACIC RESEARCH
(2023)
Review
Materials Science, Multidisciplinary
Ali Tarighatnia, Mohammad Reza Fouladi, Nader D. Nader, Ayuob Aghanejad, Hossein Ghadiri
Summary: Ultrasound imaging is a frequently used diagnostic modality for visualizing different diseases, with advantages of real-time imaging, portability, low cost, and safety. Novel contrast agents have improved the sensitivity and specificity of ultrasound imaging, enabling the detection of diseases at earlier stages. Selecting nanoparticles with appropriate structure and performance that can bind to the target is a powerful strategy for targeted imaging and early disease detection. The technical detection modes and quantitative analysis of ultrasound imaging are affected by disease diagnosis.
MATERIALS ADVANCES
(2022)
