期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 16, 期 33, 页码 6086-6095出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8ob01817k
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资金
- Centre National de la Recherche Scientifique (CNRS)
- COST-EURELAX action from EU [CA15209]
- Dipartimento di Fisica of Universita degli Studi di Milano
GM3-ganglioside is known to be involved in melanoma proliferation. In order to modulate metastatic-related events, we have functionalized multi-walled carbon nanotubes (MWCNTs) with multiple copies of a GM3-lactone mimetic. The MWCNTs proved to guarantee the appropriate spatial arrangement of the mimetic allowing a stronger inhibition of migration and invasiveness of human melanoma (A375) cells compared to other multivalent constructs reported before. In addition, the effect of the multivalent tubular conjugate on the inhibition of specific tyrosine kinases, which are associated with the ganglioside complexes within the membrane domains, was demonstrated. Finally, the short-term fate of the conjugate was assessed, for the first time, by means of the H-1 NMR relaxometry technique by exploiting the signal arising from the CNTs.
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