Article
Engineering, Environmental
You Zhang, Wenhong Fan, Xiaomin Li, Wen-Xiong Wang, Shu Liu
Summary: In this study, nanobubble technology and hydrogen water were combined for the first time to remove reactive oxygen species caused by environmental stress. Hydrogen nanobubbles showed remarkable capability in removing H2O2 and O(2)(center dot- ), and increasing the activity and expression of antioxidant enzymes.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Leanne E. Mocniak, Zachary T. Bitzer, Neil Trushin, John P. Richie
Summary: Tobacco smoke free radicals, which depend on the intrinsic nitrate levels in tobacco, are closely associated with adverse health effects. The levels of gas phase radicals are highly correlated with nitrate levels in different tobacco types and brands. Nitrate addition to tobacco leaves increases the production of gas phase radicals and NNK in smoke. Tobacco nitrate plays a key role in the production of gas phase radicals and has implications for health regulation.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Kozo Nakai, Daisuke Tsuruta
Summary: Oxygen in the atmosphere is vital for human life, but the metabolites ROS, produced in excess, can exacerbate skin aging and inflammation. Excessive exposure to air pollutants and other harmful substances can stimulate the production of ROS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
V. G. Damle, K. Wu, D. J. Arouri, R. Schirhagl
Summary: Free radicals play a key role in viral infections, with varying effects on different types of viruses and radical species. They can contribute to defense against viruses or increase viral load. Therefore, antioxidants are used in the treatment of viral infections.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Damian M. Bailey, Marcel Culcasi, Teresa Filipponi, Julien V. Brugniaux, Benjamin S. Stacey, Christopher J. Marley, Rodrigo Soria, Stefano F. Rimoldi, David Cerny, Emrush Rexhaj, Lorenza Pratali, Carlos Salinas Salmon, Carla Murillo Jauregui, Mercedes Villena, Francisco Villafuerte, Antal Rockenbauer, Sylvia Pietri, Urs Scherrer, Claudio Sartori
Summary: Chronic mountain sickness (CMS) is a high-altitude maladaptation syndrome characterized by elevated systemic oxidative-nitrosative stress. This study found that highlanders have permanently elevated systemic oxidative-nitrosative stress levels, which are further increased in CMS+ patients, leading to systemic vascular complications and increased morbidity/mortality.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Review
Chemistry, Multidisciplinary
Priya Chaudhary, Pracheta Janmeda, Anca Oana Docea, Balakyz Yeskaliyeva, Ahmad Faizal Abdull Razis, Babagana Modu, Daniela Calina, Javad Sharifi-Rad
Summary: Free radicals are reactive oxygen species that circulate through the body and can contribute to the development of diseases when their natural removal mechanisms are disrupted.
FRONTIERS IN CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Enrique Cadenas, Helmut Sies
Summary: Lester Packer, an inspirational scientific leader, had a profound impact on researchers in the field of oxidants and antioxidants. This article highlights key aspects of his career, from his early years at Brooklyn College and Yale University to his influential role at the University of California, Berkeley. His concept of the Antioxidant Network and his ability to foster international collaborations made him a respected figure in the scientific community.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Review
Medicine, Research & Experimental
Muhammad Torequl Islam, Chandan Sarkar, Rajib Hossain, Md. Shimul Bhuia, Ileana Mardare, Marzhan Kulbayeva, Alibek Ydyrys, Daniela Calina, Solomon Habtemariam, Marek Kieliszek, Javad Sharifi-Rad, William C. Cho
Summary: Rheumatic diseases and disorders (RDDs) are chronic autoimmune diseases caused by genetic and environmental factors. Redox imbalance is found to be a serious consequence of RDDs, and an in-depth understanding of this imbalance is crucial for therapeutic strategies. Studies also suggest that peroxiredoxins and changes in lifestyle and diet may provide potential avenues for intervention.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Bozidarka L. Zaric, Mirjana T. Macvanin, Esma R. Isenovic
Summary: This review provides a systematic summary of the biochemical characteristics of various types of reactive species and specifies their localization and mechanisms of production in cells. Additionally, it discusses the specific roles of free radicals in cellular physiology, focusing on the current research aiming to identify the cascades of reactions initiated by reactive oxygen species that result in adaptive or pathological cellular responses. Finally, recent findings regarding therapeutic modulations of intracellular levels of reactive oxygen species are presented, which may have significant implications for developing novel agents for treating several diseases.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Bhanwar Kumar Malviya, Karandeep Singh, Pradeep K. Jaiswal, Manvika Karnatak, Ved Prakash Verma, Satpal Singh Badsara, Siddharth Sharma
Summary: This study reports a catalyst-free synthesis of 6-aryl phenanthridines and amides through an electrochemical reaction. Detailed mechanistic studies revealed that the coupling reaction proceeds by the cathodic reduction of in situ formed diazonium ions, which then coupled with isocyanides to furnish the desired products in good yields.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Anouchka Gatin, Patricia Duchambon, Guillaume van der Rest, Isabelle Billault, Cecile Sicard-Roselli
Summary: This study investigates the dimerization behavior of tyrosine when embedded in a peptidic sequence. The results show that the formation of tyrosine dimers is a slow process and involves the co-existence of intermediates and final products. The involvement of amide functions in protein dimerization is also suggested.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
R. Giancaspro, M. Cassano, M. Gelardi
Summary: This review aims to elucidate the mechanisms of oxidative stress and the development and progression of various diseases related to oxidative stress.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Article
Multidisciplinary Sciences
Thales Henrique B. De Oliveira, Norma B. De Gusmao, Leonor A. O. Da Silva, Luana C. B. B. Coelho
Summary: Free radicals are harmful to human health and antioxidants can stabilize these molecules. Actinobacteria, a less explored natural source of antioxidants, has been found to possess important capacity in producing these compounds.
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
(2021)
Article
Materials Science, Biomaterials
Ping Huang, Zihong Li, Li Nong, Jie Cheng, Weiying Lin
Summary: Aging is a natural process characterized by the decline of physiological functions in the body's organs and tissues. Oxidative stress, caused by active nitrogen substances like ONOO-, is considered to be the main cause of aging. Detecting changes in ONOO- in aging cells is important for studying senescence. In this study, we developed a fluorescent probe FLASN based on flavonol that can detect and treat ONOO- in cells. Our results showed that FLASN can effectively detect ONOO- in cells and reduce its production stimulated by metformin. This study provides a new perspective on the role of ONOO- in senescence and the potential therapeutic effect of flavonol.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Multidisciplinary
Canan Demir, Siddik Keskin, Fatih Sen
Summary: Free radicals are highly reactive chemical molecules with unpaired electrons. This study evaluated the availability of Malondialdehyde, Superoxide dismutase, Catalase, and Reduced glutathione levels as markers for related diseases. Analysis of means and Nonlinear Principal Component Analysis were used as graphical procedures to compare group means and visualize the relationship between biochemical characteristics and related diseases.
FRONTIERS IN CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Lynsey Dunbar, Rebecca J. Sowden, Katherine D. Trotter, Michelle K. Taylor, David Smith, Alan R. Kennedy, John Reglinski, Corinne M. Spickett
Article
Chemistry, Organic
Edward T. Ledingham, Christopher J. Merritt, Christopher J. Sumby, Michelle K. Taylor, Ben W. Greatrex
SYNTHESIS-STUTTGART
(2017)
Article
Chemistry, Multidisciplinary
Nichole P. H. Tan, Michelle K. Taylor, Steven E. Bottle, Christine E. Wright, James Ziogas, Jonathan M. White, Carl H. Schiesser, Nitya V. Jani
CHEMICAL COMMUNICATIONS
(2011)
Article
Chemistry, Inorganic & Nuclear
Victor W. L. Ng, Michelle K. Taylor, Lyndal M. R. Hill, Jonathan M. White, Charles G. Young
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2010)
Article
Chemistry, Inorganic & Nuclear
Lyndal M. R. Hill, Michelle K. Taylor, Victor Wee Lin Ng, Charles G. Young
INORGANIC CHEMISTRY
(2008)
Article
Chemistry, Inorganic & Nuclear
Victor W. L. Ng, Michelle K. Taylor, Jonathan M. White, Charles G. Young
INORGANIC CHEMISTRY
(2010)
Article
Chemistry, Inorganic & Nuclear
Stephen Sproules, Aston A. Eagle, Michelle K. Taylor, Robert W. Gable, Jonathan M. White, Charles G. Young
INORGANIC CHEMISTRY
(2011)
Article
Chemistry, Inorganic & Nuclear
Victor Wee Lin Ng, Michelle K. Taylor, Charles G. Young
INORGANIC CHEMISTRY
(2012)
Article
Chemistry, Inorganic & Nuclear
Jonathan M. White, Victor W. L. Ng, Damian C. Clarke, Paul D. Smith, Michelle K. Taylor, Charles G. Young
INORGANICA CHIMICA ACTA
(2009)
Article
Chemistry, Inorganic & Nuclear
Katherine D. Trotter, Michelle K. Taylor, John C. Forgie, John Reglinski, Leonard E. A. Berlouis, Alan R. Kennedy, Corinne M. Spickett, Rebecca J. Sowden
INORGANICA CHIMICA ACTA
(2010)
Article
Chemistry, Inorganic & Nuclear
Craig Gourlay, Michelle K. Taylor, Paul D. Smith, Charles G. Young
INORGANICA CHIMICA ACTA
(2010)
Article
Chemistry, Organic
Maree K. Staples, Rebecca L. Grange, James A. Angus, James Ziogas, Nichole P. H. Tan, Michelle K. Taylor, Carl H. Schiesser
ORGANIC & BIOMOLECULAR CHEMISTRY
(2011)
Article
Chemistry, Organic
Marilena A. Giarrusso, Michelle K. Taylor, James Ziogas, Kate M. Brody, Phoebe E. Macdougall, Carl H. Schiesser
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2012)
Article
Behavioral Sciences
Ariella Y. Moser, Wendy Y. Brown, Lewis A. Bizo, Nigel R. Andrew, Michelle K. Taylor
Article
Chemistry, Organic
Faiza Diaba, Gisela Trenchs
Summary: The first violet light-mediated synthesis of gamma- and delta-lactams from N-alkenyl trichloroacetamides is reported in this paper. The reactions are conducted in tetrahydrofuran or 2-methyltetrahydrofuran as the sole solvent without catalysts or additives, under non-anhydrous conditions in an air atmosphere where the solvent serves as the radical initiator.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Feroze Hussain, Sajjad Ahmed, Ashiq Hussain Padder, Qazi Naveed Ahmed
Summary: This study reports a novel and efficient one-pot synthesis method for mixed phosphorotrithioates, which does not require supplementary additives and shows broad applicability.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Hyunjin Oh, Ikyon Kim
Summary: A new 1,2,4-triazole-pyrrolo[1,2-a]pyrazine hybrid system, 6-acylpyrrolo[1,2-a][1,2,4]triazolo[5,1-c]pyrazine, was synthesized using a catalyst-free method. This method involved sequential exposure of pyrrole-2-carbonitrile-derived substrates to DMF-DMA and acyl hydrazide, resulting in the formation of acylated pyrazine and 1,2,4-triazole rings, enabling the installation of various substituents at specific positions on the core skeleton.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Ming Yan, Si-fan Wang, Yong-po Zhang, Jin-zhong Zhao, Zhuo Tang, Guang-xun Li
Summary: Here we developed an efficient photocatalytic approach for the convenient preparation of sulfinamides. The reaction allows for the gram-scale preparation of sulfinamides and the one-pot synthesis of various sulfonyl amides.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Farzaneh Bandehali-Naeini, Zahra Tanbakouchian, Noushin Farajinia-Lehi, Nicolas Mayer, Morteza Shiri, Martin Breugst
Summary: Two tandem catalytic systems were developed for the synthesis of novel 3,4-disubstituted maleimides using the same Ugi adducts. Different maleimide structures can be synthesized using either Pd or Cu catalysis.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Tanya Raghava, Anjan Chattopadhyay, Subhadeep Banerjee, Nivedita Sarkar
Summary: Amine substitution of two ortho fluorine atoms of tetrafluoroterephthalonitrile through SNAr chemistry is easily achievable. But further fluorine substitution is only possible under forcing conditions, yielding valuable fluorophores for bioimaging.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Review
Chemistry, Organic
Anju Chadha, Santosh Kumar Padhi, Selvaraj Stella, Sowmyalakshmi Venkataraman, Thangavelu Saravanan
Summary: Alcohol dehydrogenases are enzymes that use cofactors for oxidation or reduction reactions of alcohols or carbonyl compounds. They are utilized in green chemistry and have applications in the production of pharmaceuticals. Recombinant enzymes have solved the challenge of producing purified enzymes in large quantities. Engineered alcohol dehydrogenases have been used in asymmetric synthesis in industry. Various methods have been established for regenerating expensive cofactors to make the enzymatic process more efficient and economically viable.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
