Article
Chemistry, Applied
Christian Leonardo Herrera, Joao Victor Santiago, Julio Cezar Pastre, Carlos Roque Duarte Correia
Summary: This study describes a method for the enantioselective Heck-Matsuda reaction of cyclic and acyclic olefins directly from anilines. The method demonstrates a broad substrate scope and high enantioselectivity and yield in the synthesis of Heck adducts.
ADVANCED SYNTHESIS & CATALYSIS
(2022)
Article
Chemistry, Applied
Tomaz Henrique Duarte Chorro, Edson Leonardo Scarpa de Souza, Otto Daolio Koster, Ellen Christine Polo, Rafaela Costa Carmona, Vitor Hugo Menezes da Silva, Joao Marcos Batista Junior, Carlos Roque Duarte Correia
Summary: A new enantioselective intramolecular strategy for the synthesis of enantioenriched bridged benzoxacines, unsaturated spirobenzofurans, 2,3-dihydrobenzofuran, and 2,3-indoline acetate scaffolds directly from anilines has been developed. The process combines in situ diazotization of the aniline with intramolecular Heck-Matsuda reaction, eliminating the need for isolation and purification of potentially unstable or hard-to-synthesize aryldiazonium salts. The method has been demonstrated to be practical and robust, achieving high yields and enantiomeric ratios.
ADVANCED SYNTHESIS & CATALYSIS
(2023)
Article
Chemistry, Applied
Zixuan Zhu, Xinyi Pan, Wenlong Zhang, Heting Li, Wei Wang, Yaning He
Summary: In this study, an amphiphilic block copolymer with PS and PS-based polymeric diazonium salts was synthesized. The self-assembled nano-sized micelles in selective solvents were formed, with the diazonium groups playing a critical role in colloidal stability and post-modification.
REACTIVE & FUNCTIONAL POLYMERS
(2022)
Article
Chemistry, Organic
Gangqi Peng, Hao Cheng, Xiya Cheng, Yang He, Yuanyuan An, Jie Wu, Danqing Zheng
Summary: A reductive Sandmeyer-type sulfinylation reaction of aryldiazonium salts with sodium sulfinates was developed, which proceeds under photocatalysis and generates various sulfoxides of significant value via radical substitution pathway. The in situ diazotization of aromatic amines in a one-pot, two-step process also allows for the conversion to corresponding sulfoxides. The successful late-stage sulfinylation of drug-based amines further demonstrates the practicality of this method.
ORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Chemistry, Physical
Haifeng Zheng, Kan Wang, Isa Faghihi, Wendell P. Griffith, Hadi Arman, Michael P. Doyle
Summary: Metal-free electrophile addition to vinyl diazo compounds leads to highly selective formal [3 + 2] cyclization, 1,2-difunctionalization of alkenes, and C-H functionalization. Diverse electrophilic reagents can be used to generate highly reactive intermediates, enabling the synthesis of various substituted alpha-diazo esters with high yields and selectivities. Further transformations such as migration, oxidation, ring-expansion, and conjugate addition demonstrate the potential utility of this method.
Review
Environmental Sciences
Xiao Liu, Hao Zhang, Xiaoyang Zhang, Yanchun Yang, Chunzhen Yang, Pei Zhao, Yong Dong
Summary: Friedel's salt precipitation (FSP) method is an efficient technique for chloride removal, which has attracted significant attention in the zero liquid discharge of Flue Gas Desulfurization (FGD) wastewater. This paper provides a comprehensive understanding of the FSP method, including its evolution, reaction mechanisms, influential factors, and recent research progress. The FSP method utilizes lime and aluminate to remove chloride ions from saline wastewater through adsorption or/and ion exchange reactions, forming Friedel's salt. The effluent can be reused as makeup water, while the dechloridation precipitates can be reclaimed as adsorption materials and sludge conditioners, offsetting treatment costs and avoiding secondary pollution. The FSP method shows promising potential for achieving zero liquid discharge in FGD wastewater and other chloride-containing wastewater.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Chemistry, Organic
Rochelle McGrory, Rebecca Clarke, Olivia Marshall, Andrew Sutherland
Summary: The Heck-Matsuda coupling reaction of arenediazonium salts derived from l-phenylalanine with various alkenes has been developed, enabling the synthesis of unnatural α-amino acids with cinnamate, vinylsulfone, and stilbene side-chains. The photophysical analysis shows that the (E)-stilbene analogues exhibit enhanced fluorescence properties compared to l-phenylalanine, with red-shifted absorption and emission spectra and larger quantum yields.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Chemistry, Applied
Laura Rodriguez-Fernandez, Jesus Albarran-Velo, Ivan Lavandera, Vicente Gotor-Fernandez
Summary: The photocatalytic Meerwein arylation between aromatic diazonium salts and isopropenyl acetate in aqueous medium was studied under blue LED light irradiation. Optimization of reaction conditions allowed the synthesis of various 1-arylpropan-2-ones with up to 95% yield using [Acr-Mes]ClO4 as the photocatalyst. Furthermore, a one-pot sequential photobiocatalytic approach combining the Meerwein arylation with bioreduction of ketone intermediates was developed, leading to the synthesis of 1-arylpropan-2-ol enantiomers with up to 76% overall yield and high stereoselectivity.
ADVANCED SYNTHESIS & CATALYSIS
(2023)
Article
Chemistry, Organic
Ling Li, Shiqi Zhang, Xiongfei Deng, Guangxun Li, Zhuo Tang, Gang Zhao
Summary: A metal-free and operationally simple strategy has been developed for the synthesis of α-imino ketones with high regioselectivity, as well as various N,O-ketals with high regioselectivities and diastereoselectivities through cascade reactions in one pot.
Article
Chemistry, Analytical
Elena A. Chiticaru, Luisa Pilan, Mariana Ionita
Summary: In this paper, an improved electrochemical platform based on graphene was proposed for the detection of DNA hybridization. Commercial screen-printed carbon electrodes were modified with reduced graphene oxide and aryl-carboxyl groups to immobilize DNA probes. The fabrication process was monitored by cyclic voltammetry and electrochemical impedance spectroscopy, and the morphological and structural characterization of the modified electrodes was performed using scanning electron microscopy and Raman spectroscopy. This platform shows potential for label-free detection of DNA hybridization.
Article
Nanoscience & Nanotechnology
Mateusz Michal Tomczyk, Masafumi Minoshima, Kazuya Kikuchi, Agata Blacha-Grzechnik, Zbigniew Starosolski, Rohan Bhavane, Mariusz Zalewski, Nikodem Kuznik
Summary: The attachment of functional molecules to single-walled carbon nanotubes (SWCNTs) using aryl diazonium salt chemistry can enhance their near-infrared emission. In this study, sp(3) defects were created on (6,5) SWCNTs using aryl diazonium salt of fluorescein. The pH was found to affect the grafting process, with pH 5-6 being necessary for a successful reaction. The modified SWCNTs exhibited red-shifted NIR emission due to luminescent sp(3) defects, as well as visible fluorescence from attached fluorescein molecules.
Article
Chemistry, Organic
Haichao Huang, Hailong Wang, Chao Gong, Zhenjing Zhuang, Wenmin Feng, Si-Hai Wu, Lianhui Wang
Summary: The regioselective redox-neutral [3 + 3]-cycloaddition of anilines with CF3-ynones was achieved using a traceless directing group strategy catalyzed by rhodium. A variety of substituted 2-trifluromethylquinoline compounds were obtained in good to excellent yields, exhibiting favorable blue emission properties.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Multidisciplinary
Li Wang, Rui Peng, Xue Liu, Chendi Heng, Yanni Miao, Wei Wang, Andrew Carrier, Ken Oakes, Xu Zhang
Summary: An innovative biofilm removal technology was developed based on nitrite-accelerated Fenton chemistry, utilizing dissolved Cu ions and nano-CuO surfaces to efficiently generate reactive nitrogen species as disinfectants. This simple, efficient, and cost-effective approach provides important insights into Fenton chemistry, considering the ubiquity of copper, hydrogen peroxide, and nitrite in the environment, biological systems, and various industrial processes.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Physical
Renbo Zhu, Yanzhe Zhu, Fandi Chen, Robert Patterson, Yingze Zhou, Tao Wan, Long Hu, Tom Wu, Rakesh Joshi, Mengyao Li, Claudio Cazorla, Yuerui Lu, Zhaojun Han, Dewei Chu
Summary: This article reports a simple strategy to modify graphene oxide and improve the electric output of moisture-electric generators. By assembling multiple generator units in series or parallel, the electric output can be further improved. This technology has great commercial potential for flexible and wearable applications.
Article
Environmental Sciences
Zongwen Zhao, Weining Qin, Jiang Long, Jie Lei, Wenbin Xu, Zhongbing Wang
Summary: In this study, pyrolysis treatment was used to remove the organic impurities in industrial waste salt (IWS), and the optimal process parameters were determined. The results showed that pyrolysis effectively reduced the total organic carbon (TOC) content and transformed the composition of organic impurities. These findings provide theoretical support for the resource utilization of IWS.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Chemistry, Organic
Faiza Diaba, Gisela Trenchs
Summary: The first violet light-mediated synthesis of gamma- and delta-lactams from N-alkenyl trichloroacetamides is reported in this paper. The reactions are conducted in tetrahydrofuran or 2-methyltetrahydrofuran as the sole solvent without catalysts or additives, under non-anhydrous conditions in an air atmosphere where the solvent serves as the radical initiator.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Feroze Hussain, Sajjad Ahmed, Ashiq Hussain Padder, Qazi Naveed Ahmed
Summary: This study reports a novel and efficient one-pot synthesis method for mixed phosphorotrithioates, which does not require supplementary additives and shows broad applicability.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Hyunjin Oh, Ikyon Kim
Summary: A new 1,2,4-triazole-pyrrolo[1,2-a]pyrazine hybrid system, 6-acylpyrrolo[1,2-a][1,2,4]triazolo[5,1-c]pyrazine, was synthesized using a catalyst-free method. This method involved sequential exposure of pyrrole-2-carbonitrile-derived substrates to DMF-DMA and acyl hydrazide, resulting in the formation of acylated pyrazine and 1,2,4-triazole rings, enabling the installation of various substituents at specific positions on the core skeleton.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Ming Yan, Si-fan Wang, Yong-po Zhang, Jin-zhong Zhao, Zhuo Tang, Guang-xun Li
Summary: Here we developed an efficient photocatalytic approach for the convenient preparation of sulfinamides. The reaction allows for the gram-scale preparation of sulfinamides and the one-pot synthesis of various sulfonyl amides.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Farzaneh Bandehali-Naeini, Zahra Tanbakouchian, Noushin Farajinia-Lehi, Nicolas Mayer, Morteza Shiri, Martin Breugst
Summary: Two tandem catalytic systems were developed for the synthesis of novel 3,4-disubstituted maleimides using the same Ugi adducts. Different maleimide structures can be synthesized using either Pd or Cu catalysis.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Tanya Raghava, Anjan Chattopadhyay, Subhadeep Banerjee, Nivedita Sarkar
Summary: Amine substitution of two ortho fluorine atoms of tetrafluoroterephthalonitrile through SNAr chemistry is easily achievable. But further fluorine substitution is only possible under forcing conditions, yielding valuable fluorophores for bioimaging.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Review
Chemistry, Organic
Anju Chadha, Santosh Kumar Padhi, Selvaraj Stella, Sowmyalakshmi Venkataraman, Thangavelu Saravanan
Summary: Alcohol dehydrogenases are enzymes that use cofactors for oxidation or reduction reactions of alcohols or carbonyl compounds. They are utilized in green chemistry and have applications in the production of pharmaceuticals. Recombinant enzymes have solved the challenge of producing purified enzymes in large quantities. Engineered alcohol dehydrogenases have been used in asymmetric synthesis in industry. Various methods have been established for regenerating expensive cofactors to make the enzymatic process more efficient and economically viable.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)