Design, synthesis, and biological evaluation of novel trifluoromethyl indoles as potent HIV-1 NNRTIs with an improved drug resistance profile

Discovery of dimeric inhibitors by extension into the entrance channel of HIV-1 reverse transcriptase

(2012) Anil R. Ekkati et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, Synthesis, and Preclinical Evaluations of Novel 4-Substituted 1,5-Diarylanilines as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) Drug Candidates

(2012) Lian-Qi Sun et al.   JOURNAL OF MEDICINAL CHEMISTRY

New Nitrogen Containing Substituents at the Indole-2-carboxamide Yield High Potent and Broad Spectrum Indolylarylsulfone HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors

(2012) Giuseppe La Regina et al.   JOURNAL OF MEDICINAL CHEMISTRY

Molecular Mechanism of Antagonism between the Y181C and E138K Mutations in HIV-1 Reverse Transcriptase

(2012) H.-T. Xu et al.   JOURNAL OF VIROLOGY

Synthesis and anti-tumor activity of 2-amino-3-cyano-6-(1H-indol-3-yl)-4-phenylpyridine derivatives in vitro

(2011) Fan Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Indolylarylsulfones as HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: New Cyclic Substituents at Indole-2-carboxamide

(2011) Giuseppe La Regina et al.   JOURNAL OF MEDICINAL CHEMISTRY

Computationally-Guided Optimization of a Docking Hit to Yield Catechol Diethers as Potent Anti-HIV Agents

(2011) Mariela Bollini et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design and Synthesis of Conformationally Constrained Inhibitors of Non-Nucleoside Reverse Transcriptase

(2011) Robert Gomez et al.   JOURNAL OF MEDICINAL CHEMISTRY

Efficient Discovery of Potent Anti-HIV Agents Targeting the Tyr181Cys Variant of HIV Reverse Transcriptase

(2011) William L. Jorgensen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A microwave-assisted, propylphosphonic anhydride (T3P®) mediated one-pot Fischer indole synthesis

(2011) Matthieu Desroses et al.   TETRAHEDRON LETTERS

Characterization of Genotypic and Phenotypic Changes in HIV-1-Infected Patients with Virologic Failure on an Etravirine-Containing Regimen in the DUET-1 and DUET-2 Clinical Studies

(2010) Lotke Tambuyzer et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Design, Synthesis, and Evaluation of Diarylpyridines and Diarylanilines as Potent Non-nucleoside HIV-1 Reverse Transcriptase Inhibitors

(2010) Xingtao Tian et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of substituted indoles using continuous flow micro reactors

(2010) Ben Wahab et al.   TETRAHEDRON

Direct Catalytic Asymmetric Synthesis of Highly Functionalized 2-Methylchroman-2,4-diols via Barbas-List Aldol Reaction

(2009) Dhevalapally B. Ramachary et al.   CHEMISTRY-A EUROPEAN JOURNAL

Indolylarylsulfones Bearing Natural and Unnatural Amino Acids. Discovery of Potent Inhibitors of HIV-1 Non-Nucleoside Wild Type and Resistant Mutant Strains Reverse Transcriptase and Coxsackie B4 Virus

(2009) Francesco Piscitelli et al.   JOURNAL OF MEDICINAL CHEMISTRY

New Arylthioindoles and Related Bioisosteres at the Sulfur Bridging Group. 4. Synthesis, Tubulin Polymerization, Cell Growth Inhibition, and Molecular Modeling Studies

(2009) Giuseppe La Regina et al.   JOURNAL OF MEDICINAL CHEMISTRY

Efficient Synthesis of 2-Ethoxycarbonyl Indoles

(2009) A. Sudhakara et al.   SYNTHETIC COMMUNICATIONS

A pharmacokinetic study of etravirine (TMC125) co-administered with ranitidine and omeprazole in HIV-negative volunteers

(2008) Monika Schöller-Gyüre et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Etravirine for the treatment of HIV infection

(2008) E Seminari et al.   Expert Review of Anti-Infective Therapy

High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: Strategic flexibility explains potency against resistance mutations

(2008) K. Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA