Facile synthesis of 5-hydroxy-L-lysine from D-galactose as a chiral-precursor

A concise synthesis of (2S,5R) and (2S,5S)-5-hydroxy-lysine was achieved by utilizing D-galactose as a chiral-precursor with stereo retention. This synthetic strategy showcased the potential of utilizing carbohydrates as starting materials to prepare amino acids. Using the diazido intermediate, the derived beta-D-galactopyranosyl and alpha-D-glucopyranosyl-(1 -> 2)-beta-D-galactosyl moieties were synthesized.