Design, synthesis and evaluation of novel tacrine–rhein hybrids as multifunctional agents for the treatment of Alzheimer's disease

Nontoxic and Neuroprotective β-Naphthotacrines for Alzheimer’s Disease

(2013) Mario Esquivias-Pérez et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Recent advances in natural products from plants for treatment of liver diseases

(2013) Aihua Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Multifunctional tacrine–flavonoid hybrids with cholinergic, β-amyloid-reducing, and metal chelating properties for the treatment of Alzheimer's disease

(2013) Su-Yi Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Rhein lysinate decreases the generation of β-amyloid in the brain tissues of Alzheimer's disease model mice by inhibiting inflammatory response and oxidative stress

(2013) Jiang Liu et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

Bone-targeting glycol and NSAIDS ester prodrugs of rhein: Synthesis, hydroxyapatite affinity, stability, anti-inflammatory, ulcerogenicity index and pharmacokinetics studies

(2012) Jin Cai et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Tacrine–Ferulic Acid–Nitric Oxide (NO) Donor Trihybrids as Potent, Multifunctional Acetyl- and Butyrylcholinesterase Inhibitors

(2012) Yao Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

New Tacrine–4-Oxo-4H-chromene Hybrids as Multifunctional Agents for the Treatment of Alzheimer’s Disease, with Cholinergic, Antioxidant, and β-Amyloid-Reducing Properties

(2012) María Isabel Fernández-Bachiller et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Biological Activity of New 2,3-dihydro-1H-cyclopenta[b]- quinoline Derivatives as Acetylcholinesterase Inhibitors

(2012) Pawel Szymanski et al.   Letters in Drug Design & Discovery

Pharmacokinetics screening for multi-components absorbed in the rat plasma after oral administration traditional Chinese medicine formula Yin-Chen-Hao-Tang by ultra performance liquid chromatography-electrospray ionization/quadrupole-time-of-flight mass spectrometry combined with pattern recognition methods

(2011) Xijun Wang et al.   ANALYST

Hybrids of oxoisoaporphine-tacrine congeners: Novel acetylcholinesterase and acetylcholinesterase-induced β-amyloid aggregation inhibitors

(2011) Huang Tang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Benzophenone-based derivatives: A novel series of potent and selective dual inhibitors of acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation

(2011) Federica Belluti et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Rhein protects against acetaminophen-induced hepatic and renal toxicity

(2011) Yan-Ling Zhao et al.   FOOD AND CHEMICAL TOXICOLOGY

Tacrine-mefenamic acid hybrids for inhibition of acetylcholinesterase

(2011) Joshua J. Bornstein et al.   MedChemComm

Evidence of Oxidative Stress in Alzheimer's Disease Brain and Antioxidant Therapy

(2010) Domenico Praticò   Annals of the New York Academy of Sciences

Tacrine Derivatives and Alzheimers Disease

(2010) V. Tumiatti et al.   CURRENT MEDICINAL CHEMISTRY

Novel Tacrine−8-Hydroxyquinoline Hybrids as Multifunctional Agents for the Treatment of Alzheimer’s Disease, with Neuroprotective, Cholinergic, Antioxidant, and Copper-Complexing Properties

(2010) María Isabel Fernández-Bachiller et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cholinesterase Inhibitors and Beyond

(2009) Giancarlo Pepeu et al.   Current Alzheimer Research

Hyperphosphorylation of Microtubule-Associated Protein Tau: A Promising Therapeutic Target for Alzheimer Disease

(2008) C.-X. Gong et al.   CURRENT MEDICINAL CHEMISTRY

Novel Donepezil-Based Inhibitors of Acetyl- and Butyrylcholinesterase and Acetylcholinesterase-Induced β-Amyloid Aggregation

(2008) Pelayo Camps et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Biological Evaluation of NO-Donor-Tacrine Hybrids as Hepatoprotective Anti-Alzheimer Drug Candidates

(2008) Lei Fang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Experimental and Computational Studies of Selective Recognition of Hg2+by Amide Linked Lower Rim 1,3-Dibenzimidazole Derivative of Calix[4]arene: Species Characterization in Solution and that in the Isolated Complex, Including the Delineation of the Nanostructures

(2008) Roymon Joseph et al.   JOURNAL OF ORGANIC CHEMISTRY

Crystal Structure of Thioflavin T Bound to the Peripheral Site ofTorpedo californicaAcetylcholinesterase Reveals How Thioflavin T Acts as a Sensitive Fluorescent Reporter of Ligand Binding to the Acylation Site

(2008) Michal Harel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rhein inhibits invasion and migration of human nasopharyngeal carcinoma cells in vitro by down-regulation of matrix metalloproteinases-9 and vascular endothelial growth factor

(2008) Meng-Liang Lin et al.   ORAL ONCOLOGY