Article
Polymer Science
Fabian Hoeglsperger, Timo Betz, Bart Jan Ravoo
Summary: This study demonstrates the reversible modulation of osmotic pressure in an aqueous solution using photoresponsive materials. By designing suitable compounds, a drastic change in osmotic pressure can be achieved, allowing for the control of solute concentration in the solution.
Article
Chemistry, Multidisciplinary
Miriam Colaco, Patricia Maximo, A. Jorge Parola, Nuno Basilio
Summary: The study focuses on the kinetics of a water-soluble host-guest system based on cucurbit[8]uril and two DTE photoswitches, demonstrating a method to control the binding kinetics in supramolecular systems using external stimuli. By modifying the structure of the DTE guest molecule, it is possible to significantly slow down the formation/dissociation rates of pseudorotaxane structures, leading to the emergence of a competitive metastable product with important impact on the overall binding kinetics. Additionally, the dissociation kinetics of the host-guest system can be controlled by approximately 100-fold by switching between closed and open DTE isomers.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Polymer Science
Yu-Liang Lin, Sheng Zheng, Chia-Wei Chang, Min-Jie Lee, Yi-Fan Chen, Jiun-Tai Chen
Summary: In this study, versatile and on-demand photocontrollable ionic conductive nanocomposite hydrogels were successfully synthesized via host-guest chemistry. The hydrogels showed higher conductivity under visible light irradiation and lower conductivity under UV irradiation, which could be further manipulated by adjusting the surface-area-to-volume ratio of the nanopores and the alkyl chain length of the anions.
Article
Biochemistry & Molecular Biology
Lee E. Hunt, Susan A. Bourne, Mino R. Caira
Summary: The study investigates the formation of eight new crystalline complexes between methylated cyclodextrins and bioactive phenolic acids. The complexes were classified based on the extent of inclusion of the guest molecules within the cavity of the cyclodextrin molecules. The results revealed three full guest encapsulation compounds, three partial guest inclusion compounds, and two rare 'non-inclusion' compounds.
Article
Chemistry, Physical
Fengyan Fang, Zhaolei Zhang, Pingping Zhang, Xiaokang Zhang, Hongchao Ma, Yanhui Wei
Summary: Cyclodextrin-based fluorescent probes have shown great potential in chemical or biological sensing. In this study, a new probe was developed by linking DASP and B-cyclodextrin. It was found that the intermolecular inclusion complex formed by the probe would disassemble in the presence of amantadine, leading to a decrease in fluorescence intensity. This discovery provides a rapid and selective method for the detection of amantadine and suggests the potential for designing other cyclodextrin-based sensing strategies.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2024)
Article
Chemistry, Multidisciplinary
Xian-Jiang Song, Tie Zhang, Zhu-Xiao Gu, Zhi-Xu Zhang, Da-Wei Fu, Xiao-Gang Chen, Han-Yue Zhang, Ren-Gen Xiong
Summary: By controlling momentum matching in the crystal structure, a high-temperature multiaxial host-guest inclusion ferroelectric was successfully designed, with a T-c of 415 K. Compared to the parent uniaxial ferroelectric with a T-c of 127 K, this design achieved a record temperature enhancement of 288 K, providing a wide working temperature range for applications.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Polymer Science
Nikolai Liubimtsev, Zlata Zagradska-Paromova, Dietmar Appelhans, Jens Gaitzsch, Brigitte Voit
Summary: A photoresponsive double cross-linked hydrogel system was developed in this study, which can change its dimensions upon an external trigger. The azobenzene in the polymer underwent reversible conformational changes through UV light irradiation. The chemical structure of the polymer and the complex were confirmed by various measurements. The swelling/deswelling and elastic properties of the hydrogels were analyzed based on different ratios of cross-linkers and chain lengths of the macromonomers. The repeated swelling and de-swelling of the hydrogels were achieved through successive irradiation with UV and VIS light. This photoresponsive hydrogel system shows promising potential in applications such as in situ controllable valves in microfluidic flow cells.
MACROMOLECULAR CHEMISTRY AND PHYSICS
(2023)
Article
Chemistry, Multidisciplinary
Sergey Titov, Vitaly G. Avakyan
Summary: The method of molecular dynamics was used to model crystal structures based on dimers and trimers of beta-cyclodextrin containing luminescent complexes. A novel technique was developed to construct these crystals. The obtained structures are stable and allow for the explanation of the observable luminescence properties. This technique is promising for the prediction of new crystal structures and obtaining important supramolecular crystals.
Article
Chemistry, Multidisciplinary
Nicole M. Sykes, Hong Su, Susan A. Bourne, Luigi R. Nassimbeni
Summary: This study found that the host tetrakis (p-bromophenyl) ethylene can form inclusion compounds with 1,4-dioxane, cyclohexanone, dimethyl sulfoxide, and 3-pentanone, with their nonbonded host-guest interactions analyzed. The thermal decomposition of the two host center · dioxane polymorphs yielded different activation energies, and guest exchange kinetics were measured for different host-guest pairs. The reaction between host center · cyclohexanone and host · 3-pentanone was found to be deceleratory and follow the decreasing area law.
CRYSTAL GROWTH & DESIGN
(2021)
Article
Chemistry, Multidisciplinary
Zengguang Jia, Jun Zhang, Yawen Wei, Xiuhua Pan, Zongwei Hu, Ruixin Kang, Xiawei Zhou, Qi Shen
Summary: This study constructs cascade bioreactors for the treatment of TNBC by inducing ferroptosis, which activates ROS and p53 to induce cell death and activates the immune system to restrict tumor growth and metastasis.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Polymer Science
Yuuki Sugawara, Toshiyuki Hirose, Susumu Kawauchi, Takeo Yamaguchi
Summary: In this study, a poly(NIPAM-co-CD-co-DBD) material was designed to achieve highly responsive temperature-induced autonomous reswelling through CD-DBD complexation. The autonomous reswelling was successfully detected based on the fluorescent character of DBD, demonstrating the capability for visual detection.
Article
Chemistry, Multidisciplinary
Laurent Severy, Jacek Szczerbinski, Mert Taskin, Isik Tuncay, Fernanda Brandalise Nunes, Chiara Cignarella, Gabriele Tocci, Olivier Blacque, Jurg Osterwalder, Renato Zenobi, Marcella Iannuzzi, S. David Tilley
Summary: The study demonstrates a non-covalent 'click' chemistry approach to reversibly bind molecular electrocatalysts to electrode surfaces through host-guest complexation. This efficient method enables the replacement and reuse of molecular catalysts, enhancing the attractiveness of electrosynthetic systems.
Article
Chemistry, Multidisciplinary
David E. Clarke, Guanglu Wu, Ce Wu, Oren A. Scherman
Summary: Control of spatial and temporal behavior of peptide segments is crucial in fabricating functional peptide-based materials and nanostructures. Complex sequence design and inclusion of unnatural amino acids or synthetic modifications are often required to achieve desired structures. In this study, the structural properties of 1:1 inclusion complexes between specific oligopeptides and CB[8] were investigated, showing induction of turns and tunable structural chirality by altering peptide sequences. Extension of peptide sequence binding with CB[8] was also explored as a simple method to construct a peptide hairpin.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Food Science & Technology
Xingran Kou, Yaqi Zhang, Dongdong Su, Hui Wang, Xin Huang, Yunwei Niu, Qinfei Ke, Zuobing Xiao, Qingran Meng
Summary: This study characterized the inclusion complexes (ICs) of α-cyclodextrin (α-CD) with 13 aroma compounds and explored the host-guest interaction and stabilization mechanisms using various techniques. The results showed that aroma compounds weakened or disappeared after inclusion, and all ICs were crystalline. The molecular dynamics simulations revealed the preferential entry of the benzene ring and methyl group/double bond of α-terpineol into the hydrophobic cavity. The study aimed to provide a theoretical basis for the stable and controllable preparation of aroma embedding systems.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Review
Agriculture, Multidisciplinary
Wenjie Li, Weiwei Xu, Siyun Zhang, Jia Li, Juan Zhou, Demei Tian, Jing Cheng, Haibing Li
Summary: Significant progress has been made in the research on drug encapsulation and release based on supramolecular macrocycles, laying a solid foundation for the development of novel nanopesticide preparations.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Nanoscience & Nanotechnology
Remi Merindol, Sebastian Loescher, Avik Samanta, Andreas Walther
NATURE NANOTECHNOLOGY
(2018)
Article
Chemistry, Multidisciplinary
Margaret N. Holme, Subinoy Rana, Hanna M. G. Barriga, Ulrike Kauscher, Nicholas J. Brooks, Molly M. Stevens
Review
Pharmacology & Pharmacy
Ulrike Kauscher, Margaret N. Holme, Mattias Bjornmalm, Molly M. Stevens
ADVANCED DRUG DELIVERY REVIEWS
(2019)
Article
Multidisciplinary Sciences
Jelle Penders, Isaac J. Pence, Conor C. Horgan, Mads S. Bergholt, Christopher S. Wood, Adrian Najer, Ulrike Kauscher, Anika Nagelkerke, Molly M. Stevens
NATURE COMMUNICATIONS
(2018)
Article
Chemistry, Multidisciplinary
Valeria Nele, Margaret N. Holme, Ulrike Kauscher, Michael R. Thomas, James J. Doutch, Molly M. Stevens
Article
Chemistry, Multidisciplinary
Ulrike Kauscher, Jelle Penders, Anika Nagelkerke, Margaret N. Holme, Valeria Nele, Lucia Massi, Sahana Gopal, Thomas E. Whittaker, Molly M. Stevens
Article
Nanoscience & Nanotechnology
Avik Samanta, Valerio Sabatino, Thomas R. Ward, Andreas Walther
NATURE NANOTECHNOLOGY
(2020)
Article
Chemistry, Multidisciplinary
Simon Ludwanowski, Avik Samanta, Sebastian Loescher, Christopher Barner-Kowollik, Andreas Walther
Summary: The study presents a modular fluorescent probe called StyPy with a large tunable Stokes shift and diverse applicability. Through thorough characterization, StyPy is demonstrated to report viscosity changes in DNA microspheres and characterize hydrophilic and hydrophobic regions in hybrid DNA-based mesostructures.
Article
Multidisciplinary Sciences
Avik Samanta, Maximilian Hoerner, Wei Liu, Wilfried Weber, Andreas Walther
Summary: The study focuses on all-DNA protocells with a liquid DNA interior and a hydrogel-like shell, containing a catalytically active DNAzyme. These protocells convert DNA signals into functional metabolites, leading to downstream adaptation processes including intra-protocellular phenotype-like changes, prototissue formation via multivalent interactions, and chemical messenger communication between sender and receiver cell populations. Integration of DNA-nanoscience tools is crucial for mimicking life-like behavior in artificial systems for future interactive materials. Signal processing for downstream functional and morphological adaptations plays a key role in understanding and re-enacting features of living systems.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Wei Liu, Avik Samanta, Jie Deng, Cecilia Oluwadunsin Akintayo, Andreas Walther
Summary: Liquid-liquid phase separation is an important method for fabricating cell-mimicking coacervates. It has been discovered that phase separation of single-stranded DNA (ssDNA) can form protocells and microgels, but the mechanism is not fully understood. This study presents mechanistic insights into the metal-dependent phase separation of ssDNA and leverages this understanding for the formation of all-DNA droplets. The results have important implications for controlling the information transfer of DNA droplets and core-shell protocells.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Saskia Groeer, Martina Garni, Avik Samanta, Andreas Walther
Summary: Block copolymer-based polymersomes are advantageous for the design of protocells due to their higher mechanical stability and chemical versatility. In this study, two different 3D DNA origami nanopores were successfully inserted into PMOXA-b-PDMS-b-PMOXA polymersomes, expanding the design space for functional protocells based on this versatile class of large DNA origami nanopores.
Article
Chemistry, Multidisciplinary
Limor Zwi-Dantsis, Charles W. Winter, Ulrike Kauscher, Arianna Ferrini, Brian Wang, Thomas E. Whittaker, Steve R. Hood, Cesare M. Terracciano, Molly M. Stevens
Article
Materials Science, Biomaterials
Conor C. Horgan, Anika Nagelkerke, Thomas E. Whittaker, Valeria Nele, Lucia Massi, Ulrike Kauscher, Jelle Penders, Mads S. Bergholt, Steve R. Hood, Molly M. Stevens
JOURNAL OF MATERIALS CHEMISTRY B
(2020)
Article
Chemistry, Multidisciplinary
Jiawang Zhou, Yilei Wu, Indranil Roy, Avik Samanta, J. Fraser Stoddart, Ryan M. Young, Michael R. Wasielewski
Article
Cell Biology
Thomas E. Whittaker, Anika Nagelkerke, Valeria Nele, Ulrike Kauscher, Molly M. Stevens
JOURNAL OF EXTRACELLULAR VESICLES
(2020)
Article
Chemistry, Organic
Faiza Diaba, Gisela Trenchs
Summary: The first violet light-mediated synthesis of gamma- and delta-lactams from N-alkenyl trichloroacetamides is reported in this paper. The reactions are conducted in tetrahydrofuran or 2-methyltetrahydrofuran as the sole solvent without catalysts or additives, under non-anhydrous conditions in an air atmosphere where the solvent serves as the radical initiator.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Feroze Hussain, Sajjad Ahmed, Ashiq Hussain Padder, Qazi Naveed Ahmed
Summary: This study reports a novel and efficient one-pot synthesis method for mixed phosphorotrithioates, which does not require supplementary additives and shows broad applicability.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Hyunjin Oh, Ikyon Kim
Summary: A new 1,2,4-triazole-pyrrolo[1,2-a]pyrazine hybrid system, 6-acylpyrrolo[1,2-a][1,2,4]triazolo[5,1-c]pyrazine, was synthesized using a catalyst-free method. This method involved sequential exposure of pyrrole-2-carbonitrile-derived substrates to DMF-DMA and acyl hydrazide, resulting in the formation of acylated pyrazine and 1,2,4-triazole rings, enabling the installation of various substituents at specific positions on the core skeleton.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Ming Yan, Si-fan Wang, Yong-po Zhang, Jin-zhong Zhao, Zhuo Tang, Guang-xun Li
Summary: Here we developed an efficient photocatalytic approach for the convenient preparation of sulfinamides. The reaction allows for the gram-scale preparation of sulfinamides and the one-pot synthesis of various sulfonyl amides.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Farzaneh Bandehali-Naeini, Zahra Tanbakouchian, Noushin Farajinia-Lehi, Nicolas Mayer, Morteza Shiri, Martin Breugst
Summary: Two tandem catalytic systems were developed for the synthesis of novel 3,4-disubstituted maleimides using the same Ugi adducts. Different maleimide structures can be synthesized using either Pd or Cu catalysis.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Tanya Raghava, Anjan Chattopadhyay, Subhadeep Banerjee, Nivedita Sarkar
Summary: Amine substitution of two ortho fluorine atoms of tetrafluoroterephthalonitrile through SNAr chemistry is easily achievable. But further fluorine substitution is only possible under forcing conditions, yielding valuable fluorophores for bioimaging.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Review
Chemistry, Organic
Anju Chadha, Santosh Kumar Padhi, Selvaraj Stella, Sowmyalakshmi Venkataraman, Thangavelu Saravanan
Summary: Alcohol dehydrogenases are enzymes that use cofactors for oxidation or reduction reactions of alcohols or carbonyl compounds. They are utilized in green chemistry and have applications in the production of pharmaceuticals. Recombinant enzymes have solved the challenge of producing purified enzymes in large quantities. Engineered alcohol dehydrogenases have been used in asymmetric synthesis in industry. Various methods have been established for regenerating expensive cofactors to make the enzymatic process more efficient and economically viable.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
