期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 11, 期 15, 页码 2412-2416出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ob40246k
关键词
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资金
- Department of Science and Technology (DST), India
- Council of Scientific and Industrial Research (CSIR), New Delhi
An enantioselective Michael addition of cyclic 1,3-dicarbonyls to 2-enoylpyridine N-oxides catalyzed by a chiral pybox-diph-Zn(II) complex has been developed. The corresponding Michael adducts have been obtained in high yields with up to >99% ee. The Michael adduct has been transformed to biologically active 2,4-disubstituted hexahydroquinoline. A plausible transition-state model has been proposed to explain the stereochemical outcome of the reaction.
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