Synthesis and biological evaluation of benzo[a]phenazine derivatives as a dual inhibitor of topoisomerase I and II

The anticancer thiosemicarbazones Dp44mT and triapine lack inhibitory effects as catalytic inhibitors or poisons of DNA topoisomerase IIα

(2012) Jack C. Yalowich et al.   BIOCHEMICAL PHARMACOLOGY

New Tricks for an Old Natural Product: Discovery of Highly Potent Evodiamine Derivatives as Novel Antitumor Agents by Systemic Structure–Activity Relationship Analysis and Biological Evaluations

(2012) Guoqiang Dong et al.   JOURNAL OF MEDICINAL CHEMISTRY

Lithocholic acid is an endogenous inhibitor of MDM4 and MDM2

(2012) S. M. Vogel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of Inhibition of the ATPase Domain of Human Topoisomerase IIα by 1,4-Benzoquinone, 1,2-Naphthoquinone, 1,4-Naphthoquinone, and 9,10-Phenanthroquinone

(2012) Deepak Gurbani et al.   TOXICOLOGICAL SCIENCES

Recent advances in apoptosis, mitochondria and drug resistance in cancer cells

(2011) Inthrani R. Indran et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

New Strategies in the Discovery of Novel Non-Camptothecin Topoisomerase I Inhibitors

(2011) Chunquan Sheng et al.   CURRENT MEDICINAL CHEMISTRY

N-Fused Imidazoles As Novel Anticancer Agents That Inhibit Catalytic Activity of Topoisomerase IIα and Induce Apoptosis in G1/S Phase

(2011) Ashish T. Baviskar et al.   JOURNAL OF MEDICINAL CHEMISTRY

All tangled up: how cells direct, manage and exploit topoisomerase function

(2011) Seychelle M. Vos et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Recent Advances in the Development of Dual Topoisomerase I and II Inhibitors as Anticancer Drugs

(2010) S. Salerno et al.   CURRENT MEDICINAL CHEMISTRY

A Series of α-Heterocyclic Carboxaldehyde Thiosemicarbazones Inhibit Topoisomerase IIα Catalytic Activity

(2010) He Huang et al.   JOURNAL OF MEDICINAL CHEMISTRY