期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 11, 期 36, 页码 6215-6223出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ob41045e
关键词
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资金
- National Natural Science Foundation of China [21272024]
- Science and Technology Innovation Program of Beijing Institute of Technology [2011CX01008]
- Development Program for Distinguished Young and Middle-aged Teachers of Beijing Institute of Technology
An efficient chiral squaramide-catalysed enantioselective Michael addition of pyrazolin-5-ones to nitroalkenes has been developed. This reaction afforded the chiral pyrazol-3-ol derivatives in high to excellent yields (up to >99%) with high enantioselectivities (up to 94% ee) for most substrates under very low catalyst loading (0.25 mol%). This catalytic asymmetric reaction provides valuable and easy access to chiral pyrazol-3-ol derivatives, which possess potential pharmaceutical activity.
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