Hybrid ligand–alkylating agents targeting telomeric G-quadruplex structures

Kinetic and Thermodynamic Control of G-Quadruplex Folding

(2011) Yong Xue et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Conformational studies and solvent-accessible surface area analysis of known selective DNA G-Quadruplex binders

(2011) Stefano Alcaro et al.   BIOCHIMIE

Naphthalene diimide scaffolds with dual reversible and covalent interaction properties towards G-quadruplex

(2011) Matteo Nadai et al.   BIOCHIMIE

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Telomeres as targets for anticancer therapies

(2011) Marco Folini et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Structural Basis of Telomeric RNA Quadruplex−Acridine Ligand Recognition

(2011) Gavin W. Collie et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Remarkable interference with telomeric function by a G-quadruplex selective bisantrene regioisomer

(2010) Marco Folini et al.   BIOCHEMICAL PHARMACOLOGY

Tetrasubstituted naphthalene diimide ligands with selectivity for telomeric G-quadruplexes and cancer cells

(2010) Sonja M. Hampel et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Assaying and investigating Alternative Lengthening of Telomeres activity in human cells and cancers

(2010) Jeremy D. Henson et al.   FEBS LETTERS

FLAP: GRID Molecular Interaction Fields in Virtual Screening. Validation using the DUD Data Set

(2010) Simon Cross et al.   Journal of Chemical Information and Modeling

Alternative lengthening of telomeres: models, mechanisms and implications

(2010) Anthony J. Cesare et al.   NATURE REVIEWS GENETICS

Targeting the telosome: Therapeutic implications

(2009) Marco Folini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Design, synthesis and evaluation of 4,5-di-substituted acridone ligands with high G-quadruplex affinity and selectivity, together with low toxicity to normal cells

(2009) Francisco Cuenca et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Targeting G-Quadruplex DNA with Small Molecules

(2009) Nathan W. Luedtke   CHIMIA

Molecular fields in drug discovery: getting old or reaching maturity?

(2009) Simon Cross et al.   DRUG DISCOVERY TODAY

A G-quadruplex Stabilizer Induces M-phase Cell Cycle Arrest

(2009) Yuan-Chin Tsai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Isaindigotone Derivatives: A New Class of Highly Selective Ligands for Telomeric G-Quadruplex DNA

(2009) Jia-Heng Tan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting Human Gastrointestinal Stromal Tumor Cells with a Quadruplex-Binding Small Molecule

(2009) Mekala Gunaratnam et al.   JOURNAL OF MEDICINAL CHEMISTRY

Quinone Methides Tethered to Naphthalene Diimides as Selective G-Quadruplex Alkylating Agents

(2009) Marco Di Antonio et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Formation of a Unique End-to-End Stacked Pair of G-Quadruplexes in the hTERT Core Promoter with Implications for Inhibition of Telomerase by G-Quadruplex-Interactive Ligands

(2009) SunMi L. Palumbo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stabilization of quadruplex DNA perturbs telomere replication leading to the activation of an ATR-dependent ATM signaling pathway

(2009) Angela Rizzo et al.   NUCLEIC ACIDS RESEARCH

How Telomeres Solve the End-Protection Problem

(2009) T. de Lange   SCIENCE

Tri- and tetra-substituted naphthalene diimides as potent G-quadruplex ligands

(2008) Francisco Cuenca et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The Hill equation: a review of its capabilities in pharmacological modelling

(2008) Sylvain Goutelle et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Topology Conservation and Loop Flexibility in Quadruplex–Drug Recognition: Crystal Structures of Inter- and Intramolecular Telomeric DNA Quadruplex–Drug Complexes

(2008) Gary N. Parkinson et al.   JOURNAL OF MOLECULAR BIOLOGY

A hitchhiker's guide to G-quadruplex ligands

(2007) David Monchaud et al.   ORGANIC & BIOMOLECULAR CHEMISTRY