Article
Chemistry, Organic
Jeremy R. Tuck, Robert J. Tombari, Noah Yardeny, David E. Olson
Summary: In this study, arylazo-1,2,3-triazoles were successfully synthesized using azide-alkyne click chemistry, showcasing high thermal stabilities and near-quantitative bidirectional photoconversion.
Article
Chemistry, Multidisciplinary
Lorenzo Tesi, Friedrich Stemmler, Mario Winkler, Sherri S. Y. Liu, Saunak Das, Xiuming Sun, Michael Zharnikov, Sabine Ludwigs, Joris van Slageren
Summary: The development of quantum technologies aims to achieve exponentially faster computations, ultrahigh performance sensing, and a comprehensive understanding of many-particle quantum systems. Molecular spins have emerged as excellent candidates for qubits due to their long coherence times, tunability through chemical synthesis, and compatibility with other quantum platforms. However, integrating molecular spin qubits into quantum devices and preserving their quantum properties on surfaces remains a challenge. This study presents a versatile bottom-up approach to arrange molecular qubits as self-assembled monolayers on surfaces, demonstrating the maintenance or even enhancement of qubit properties.
ADVANCED MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Dmytro Dziuba, Pascal Didier, Stefano Ciaco, Anders Barth, Claus A. M. Seidel, Yves Mely
Summary: Fluorescent nucleoside analogues (FNAs) are structurally diverse mimics of natural nucleosides, used for probing nucleic acid structure and dynamics. Isomorphic and expanded FNAs are the best options for non-perturbing fluorescent labels for DNA and RNA, making significant progress in understanding their spectroscopic properties.
CHEMICAL SOCIETY REVIEWS
(2021)
Article
Chemistry, Organic
Alexey N. Butkevich
Summary: This paper presents a modular synthetic approach for preparing analogues of the far-red fluorophore silicon-rhodamine (SiR), using a regioselective double nucleophilic addition of aryllanthanum reagents to esters, anhydrides, and lactones to improve functional group tolerance. It represents a unified strategy for preparing cell-permeant SiR fluorescent labels. In combination with Pd-catalyzed hydroxy- or aminocarbonylation, it provides a streamlined synthetic pathway for a series of validated live-cell-compatible fluorescent dyes.
Article
Chemistry, Inorganic & Nuclear
Guoqing Tian, Jin-Fa Chen, Kai Zhang, Yafei Shi, Chenglong Li, Xiaodong Yin, Kanglei Liu, Pangkuan Chen
Summary: In this paper, we describe the synthesis of two axially chiral systems by incorporating B centers into binaphthyl derivatives. The resulting heteroatom-doped chiral polycyclic aromatic hydrocarbons were formed by the fusion of azaboroles to binaphthyls, which formed B-N dative bonds. The resulting B-N Lewis pairs act as attractive fluorophores and enable modulation of chiroptical properties in both solution and the solid state.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Andrew J. Neel, Ben W. H. Turnbull, William P. Carson, Tamas Benkovics, Cheol K. Chung, Heather C. Johnson, Zhuqing Liu, Feng Peng, Stephan M. Rummelt, Zhiguo Jake Song, Lushi Tan, Lu Wang, Feng Xu
Summary: Here we present a strategy for the preparation of 3'-fluorinated nucleoside analogues via aminocatalytic, electrophilic fluorination. The strategy, originally developed for the synthesis of anticancer therapeutic MK-1454, has been extended to the synthesis of various 3'-fluoronucleosides. We demonstrate the utility of the 2'-ketonucleoside synthon as a platform for further diversification and suggest that this methodology could be widely applicable to the discovery of novel nucleoside analogues.
Article
Spectroscopy
Yu Zhao, Xixi Cui, Yuzhi Song, Changzhe Zhang, Qingtian Meng
Summary: In this study, a series of fluorescent purine analogues based on P were designed to monitor DNA replication process with minimal perturbation to the natural structure of nucleic acid. The P-modified fluorescent probes exhibited red-shifted absorption spectra and enhanced photoluminescence, and efficient fluorescence quenching occurred when paired with Z. The P3 and P7 were proposed as sensors for conformational switching in the presence and absence of a complementary sequence.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Chemistry, Organic
Valentin S. Dorokhov, Samir Z. Zard
Summary: A general and flexible synthetic route to substituted pyridoazepinones has been presented in this study, enabled by the xanthate addition-transfer process. The method shows good functional group tolerance and allows the preparation of target molecules on gram scale.
Article
Multidisciplinary Sciences
Jaimon Dennis Quadros, Chetna Nagpal, Sher Afghan Khan, Abdul Aabid, Muneer Baig
Summary: The purpose of this study is to use artificial neural networks (ANN) to predict the base pressure and wall pressure in a subsonic flow field and explore the critical operating parameters affecting the subsonic flow process. The results showed that micro-jet controls were effective in increasing the base pressure for low Mach numbers and high nozzle pressure ratios. The nozzle pressure ratio and duct location to length ratio had the highest influence on the base pressure and wall pressure, respectively.
Article
Chemistry, Multidisciplinary
Robbert Q. Kim, Mohit Misra, Alexis Gonzalez, Ines Tomaskovic, Donghyuk Shin, Hermann Schindelin, Dmitri V. Filippov, Huib Ovaa, Ivan Dikic, Gerbrand J. Van der Heden van Noort
Summary: Legionnaires' disease is caused by Legionella pneumophila, which uses an unconventional ubiquitination process to replicate within host cells. This study synthesized analogues to investigate the mechanism and potential for new treatments. Synthetic Ub(ADPr) analogues were effective in pulling down overexpressed DupA from cell lysate.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Otorhinolaryngology
Giulia Molinari, Federico Calvaruso, Livio Presutti, Daniele Marchioni, Matteo Alicandri-Ciufelli, Filippo Friso, Ignacio Javier Fernandez, Pietro Francoli, Flavia Di Maro
Summary: The ExpTTA is a safe and effective technique for the treatment of small vestibular schwannomas, with low postoperative morbidity.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Oliver J. Knowles, Linus O. Johannissen, Giacomo E. M. Crisenza, Sam Hay, David Leys, David J. Procter
Summary: This study developed a new photochemical method for the synthesis of non-natural methionines from sulfides with alkenes in water, using inexpensive riboflavin as a photocatalyst. The method allows the two-step synthesis of novel methionine analogues and the selective modification of peptide side-chains to yield peptides with non-natural methionine residues.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Teng Liu, Shaofei Ni, Wusheng Guo
Summary: We have reported the first amine nucleophilic approach for the modular construction of enantioenriched protected alpha-quaternary amino acids. The use of an alcohol solvent in this method stabilizes the COOMe-bonded Cu-allenylidene electrophilic intermediate, allowing it to couple with amine nucleophiles before decomposition. This reaction has high enantioselectivity and is compatible with a wide range of functional groups. The resulting protected alpha-amino acids can be easily converted into various precious enantioenriched amines featuring alpha-hindered tertiary carbon centers.
Article
Chemistry, Applied
Martin Gericke, Lennart Hendrik Skodda, Thomas Heinze, Friedrich Schiller
Summary: A modular synthesis approach was used to obtain reactive xylan derivatives for further functionalization and chemical crosslinking. The synthesized compounds were characterized and their potential applications in preparing xylan-based hydrogels were demonstrated.
CARBOHYDRATE POLYMERS
(2023)
Article
Biochemistry & Molecular Biology
A. A. Maslova, E. C. Matyugina, E. Yu Shustova, V. P. Volok, L. Kozlovskaya, S. N. Kochetkov, A. L. Khandazhinskaya
Summary: The development of specific drugs against SARS-CoV-2 infection is a major challenge. Repurposing existing drugs and creating new molecules are the main approaches, but the current drugs lack specificity and effectiveness. The search for new SARS-CoV-2 antiviral agents continues, but no significant inhibitory effect has been found so far.
Article
Neurosciences
Jonatan A. Snir, Mojmir Suchy, Geron A. Bindseil, Michael Kovacs, Blaine A. Chronik, Robert H. E. Hudson, Stephen H. Pasternak, Robert Bartha
JOURNAL OF ALZHEIMERS DISEASE
(2018)
Review
Chemistry, Physical
Yoshio Saito, Robert H. E. Hudson
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY C-PHOTOCHEMISTRY REVIEWS
(2018)
Article
Chemistry, Organic
Masaki Yanagi, Azusa Suzuki, Robert H. E. Hudson, Yoshio Saito
ORGANIC & BIOMOLECULAR CHEMISTRY
(2018)
Article
Chemistry, Multidisciplinary
Augusto Matarazzo, Justin Brow, Robert H. E. Hudson
CANADIAN JOURNAL OF CHEMISTRY
(2018)
Article
Chemistry, Physical
Maryam Hajjami, Fatemeh Gholamian, Robert H. E. Hudson, Ali Mohammad Sanati
Article
Radiology, Nuclear Medicine & Medical Imaging
Valeriy G. Ostapchenko, Jonatan Snir, Mojmir Suchy, Jue Fan, M. Rebecca Cobb, Blaine A. Chronik, Michael Kovacs, Vania F. Prado, Robert H. E. Hudson, Stephen H. Pasternak, Marco A. M. Prado, Robert Bartha
CONTRAST MEDIA & MOLECULAR IMAGING
(2019)
Article
Chemistry, Applied
Arash Ghorbani-Choghamarani, Masoud Mohammadi, Robert H. E. Hudson, Taiebeh Tamoradi
APPLIED ORGANOMETALLIC CHEMISTRY
(2019)
Article
Chemistry, Applied
Arash Ghorbani-Choghamarani, Bahman Tahmasbi, Robert H. E. Hudson, Ali Heidari
MICROPOROUS AND MESOPOROUS MATERIALS
(2019)
Article
Chemistry, Organic
Robert H. E. Hudson, Ali Heidari, Timothy Martin-Chan, Gyeongsu Park, James A. Wisner
JOURNAL OF ORGANIC CHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Ali Heidari, Arash Ghorbani-Choghamarani, Maryam Hajjami, Robert H. E. Hudson
Article
Biochemistry & Molecular Biology
Delshanee Kotandeniya, Melanie S. Rogers, Jenna Fernandez, Sreenivas Kanugula, Robert H. E. Hudson, Freddys Rodriguez, John D. Lipscomb, Natalia Tretyakova
Summary: Cellular exposure to tobacco-specific nitrosamines leads to the formation of promutagenic DNA adducts, which can be directly repaired by a specific enzyme. By using a highly fluorescent probe, researchers have observed differences in nucleotide flipping rates during DNA repair interactions with AGT.
Article
Biochemistry & Molecular Biology
Ali Heidari, Mason Hermann, Robert H. E. Hudson
Summary: Peptide nucleic acid (PNA) is a synthetic mimic of nucleic acids capable of binding complementary oligonucleotides with high affinity and selectivity. Research has shown that pseudo-complementary PNAs can bind to double-stranded DNA via double duplex invasion, and a fluorescent assay based on phenylpyrrolocytidine (PhpC) has been developed to detect DNA strand invasion by these PNAs.
Article
Chemistry, Multidisciplinary
Jeremie Mitteaux, Pauline Lejault, Filip Wojciechowski, Alexandra Joubert, Julien Boudon, Nicolas Desbois, Claude P. Gros, Robert H. E. Hudson, Jean-Baptiste Boule, Anton Granzhan, David Monchaud
Summary: This article reports on efforts to develop in vitro assays to reliably identify molecules that can destabilize G4s. The workflow includes a newly designed G4-unfold assay, adapted from the G4-helicase assay with Pif1, as well as biophysical and biochemical techniques traditionally used to study G4/ligand interactions, and a qPCR stop assay adapted from a Taq-based protocol to identify G4s in genomic DNA. This multipronged approach leads to the characterization of a phenylpyrrolocytosine (PhpC)-based G-clamp analog as a prototype of a G4-disrupting small molecule.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Multidisciplinary
Mria Chowdhury, Robert H. E. Hudson
Summary: This review provides an overview of the advances made in nucleic acid biochemistry, particularly with regards to RNA, over the past two decades. The complexity of nucleic acids and their applications in disease treatment and research have been increasingly recognized. Fluorescence spectroscopy has emerged as an essential tool for studying the structural and functional properties of modified nucleic acids. The review focuses on the research conducted in the Hudson lab at The University of Western Ontario, highlighting the applications of modified pyrimidine nucleobases as environmentally sensitive fluorophores, base discriminating fluorophores, and G-quadruplex destabilizing agents.
Article
Chemistry, Organic
Mria Chowdhury, Julia A. Turner, Daniela Cappello, Maryam Hajjami, Robert H. E. Hudson
Summary: A library of nucleobase-chromophores inspired by green fluorescent protein (GFP) was synthesized by modifying uracil. These chromophores exhibited green emission in the visible spectrum and showed sensitivity to solvent polarity and viscosity. Some analogues displayed response when binding with DNA, indicating potential applications.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Chemistry, Organic
Faiza Diaba, Gisela Trenchs
Summary: The first violet light-mediated synthesis of gamma- and delta-lactams from N-alkenyl trichloroacetamides is reported in this paper. The reactions are conducted in tetrahydrofuran or 2-methyltetrahydrofuran as the sole solvent without catalysts or additives, under non-anhydrous conditions in an air atmosphere where the solvent serves as the radical initiator.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Feroze Hussain, Sajjad Ahmed, Ashiq Hussain Padder, Qazi Naveed Ahmed
Summary: This study reports a novel and efficient one-pot synthesis method for mixed phosphorotrithioates, which does not require supplementary additives and shows broad applicability.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Hyunjin Oh, Ikyon Kim
Summary: A new 1,2,4-triazole-pyrrolo[1,2-a]pyrazine hybrid system, 6-acylpyrrolo[1,2-a][1,2,4]triazolo[5,1-c]pyrazine, was synthesized using a catalyst-free method. This method involved sequential exposure of pyrrole-2-carbonitrile-derived substrates to DMF-DMA and acyl hydrazide, resulting in the formation of acylated pyrazine and 1,2,4-triazole rings, enabling the installation of various substituents at specific positions on the core skeleton.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Ming Yan, Si-fan Wang, Yong-po Zhang, Jin-zhong Zhao, Zhuo Tang, Guang-xun Li
Summary: Here we developed an efficient photocatalytic approach for the convenient preparation of sulfinamides. The reaction allows for the gram-scale preparation of sulfinamides and the one-pot synthesis of various sulfonyl amides.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Farzaneh Bandehali-Naeini, Zahra Tanbakouchian, Noushin Farajinia-Lehi, Nicolas Mayer, Morteza Shiri, Martin Breugst
Summary: Two tandem catalytic systems were developed for the synthesis of novel 3,4-disubstituted maleimides using the same Ugi adducts. Different maleimide structures can be synthesized using either Pd or Cu catalysis.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Tanya Raghava, Anjan Chattopadhyay, Subhadeep Banerjee, Nivedita Sarkar
Summary: Amine substitution of two ortho fluorine atoms of tetrafluoroterephthalonitrile through SNAr chemistry is easily achievable. But further fluorine substitution is only possible under forcing conditions, yielding valuable fluorophores for bioimaging.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Review
Chemistry, Organic
Anju Chadha, Santosh Kumar Padhi, Selvaraj Stella, Sowmyalakshmi Venkataraman, Thangavelu Saravanan
Summary: Alcohol dehydrogenases are enzymes that use cofactors for oxidation or reduction reactions of alcohols or carbonyl compounds. They are utilized in green chemistry and have applications in the production of pharmaceuticals. Recombinant enzymes have solved the challenge of producing purified enzymes in large quantities. Engineered alcohol dehydrogenases have been used in asymmetric synthesis in industry. Various methods have been established for regenerating expensive cofactors to make the enzymatic process more efficient and economically viable.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)