Selection of the biological activity of DNJ neoglycoconjugates through click length variation of the side chain

Glycosidase Inhibition with Fullerene Iminosugar Balls: A Dramatic Multivalent Effect

(2010) Philippe Compain et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Fluorescent sp2-Iminosugar With Pharmacological Chaperone Activity for Gaucher Disease: Synthesis and Intracellular Distribution Studies

(2010) Zhuo Luan  et al.   CHEMBIOCHEM

Fluorous Iminoalditols: A New Family of Glycosidase Inhibitors and Pharmacological Chaperones

(2010) Georg Schitter et al.   CHEMBIOCHEM

Synthesis and Evaluation of Lipophilic Aza-C-glycosides as Inhibitors of Glucosylceramide Metabolism

(2010) Tom Wennekes et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Click Chemistry Approach to New N-Substituted Aminocyclitols as Potential Pharmacological Chaperones for Gaucher Disease†

(2010) Lucía Díaz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cystic fibrosis and diabetes: isoLAB and isoDAB, enantiomeric carbon-branched pyrrolidine iminosugars

(2010) Daniel Best et al.   TETRAHEDRON LETTERS

4-C-Me-DAB and 4-C-Me-LAB—enantiomeric alkyl-branched pyrrolidine iminosugars—are specific and potent α-glucosidase inhibitors; acetone as the sole protecting group

(2010) Filipa P. da Cruz et al.   TETRAHEDRON LETTERS

Identification of Potent and Selective Glucosylceramide Synthase Inhibitors from a Library of N-Alkylated Iminosugars

(2010) Amar Ghisaidoobe et al.   ACS Medicinal Chemistry Letters

Airway Delivery of Low-Dose Miglustat Normalizes Nasal Potential Difference in F508del Cystic Fibrosis Mice

(2009) Bob Lubamba et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

A Cystic Fibrosis Respiratory Epithelial Cell Chronically Treated by Miglustat Acquires a Non–Cystic Fibrosis–Like Phenotype

(2009) Caroline Norez et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Glycosphingolipids-Nature, Function, and Pharmacological Modulation

(2009) Tom Wennekes et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chaperone Activity of Bicyclic Nojirimycin Analogues for Gaucher Mutations in Comparison withN-(n-nonyl)Deoxynojirimycin

(2009) Zhuo Luan et al.   CHEMBIOCHEM

Synthesis and Biological Characterisation of NovelN-Alkyl-Deoxynojirimycin α-Glucosidase Inhibitors

(2009) Amy J. Rawlings et al.   CHEMBIOCHEM

Improved cellular inhibitors for glycoprotein processing α-glucosidases: biological characterisation of alkyl- and arylalkyl-N-substituted deoxynojirimycins

(2009) Dominic S. Alonzi et al.   TETRAHEDRON-ASYMMETRY

Glucosylated free oligosaccharides are biomarkers of endoplasmic- reticulum α-glucosidase inhibition

(2008) Dominic S. Alonzi et al.   BIOCHEMICAL JOURNAL

New Synthetic Seven-Membered 1-Azasugars Displaying Potent Inhibition Towards Glycosidases and Glucosylceramide Transferase

(2008) Hongqing Li et al.   CHEMBIOCHEM

Identification of Pharmacological Chaperones for Gaucher Disease and Characterization of Their Effects on β-Glucocerebrosidase by Hydrogen/Deuterium Exchange Mass Spectrometry

(2008) Michael B. Tropak et al.   CHEMBIOCHEM

Parallel Improvement of Sodium and Chloride Transport Defects by Miglustat (n-Butyldeoxynojyrimicin) in Cystic Fibrosis Epithelial Cells

(2008) S. Noel et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Development of a Single Column Method for the Separation of Lipid- and Protein-Derived Oligosaccharides

(2008) David C. A. Neville et al.   JOURNAL OF PROTEOME RESEARCH

Phenylenediamine catalysis of “click glycosylations” in water: practical and direct access to unprotected neoglycoconjugates

(2008) Aurélie Baron et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Multivalent iminosugars to modulate affinity and selectivity for glycosidases

(2008) Jennifer Diot et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Large-Scale Synthesis of the Glucosylceramide Synthase InhibitorN-[5-(Adamantan-1-yl-methoxy)-pentyl]-1-deoxynojirimycin

(2008) Tom Wennekes et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT