Article
Chemistry, Multidisciplinary
Shireesha Manturthi, Kumar Pranav Narayan, Srilakshmi V. Patri
Summary: This study employed amino acid-based cationic lipids as nanocarriers for gene transfection in cancer and non-cancer cells. It was found that the proline-based lipid showed superior gene delivery activity and cellular internalization compared to methionine-based and serine-based lipids.
Article
Chemistry, Physical
Young Jin Choi, Young-Wun Kim, Kun Jun, Seong-Geun Oh, Ho-Cheol Kang
Summary: A series of new asymmetric gemini-type cationic surfactants with photo-responsive properties were synthesized successfully, exhibiting good solubility in water solutions and high yields. Light irradiation can be used to control the critical micelle concentration values of the surfactants, and their properties were compared to commercial surfactants.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Review
Biochemistry & Molecular Biology
Yu Song, Zolian S. Zoong Lwe, Pallikonda Arachchige Dona Bashanee Vinusha Wickramasinghe, Ruth Welti
Summary: Head group-acylated chloroplast lipids were discovered in the 1960s, but the interest in this field was renewed about 15 years ago with the discovery of Arabidopsides E and G, leading to the application of mass spectrometry to identify additional oxidized and non-oxidized chloroplast lipids. Despite many advances, there are still critical questions remaining about the biological functions of AGAP1 and its head group-acylated products.
Article
Chemistry, Multidisciplinary
Bappa Maiti, Krishan Kumar, Subhasis Datta, Santanu Bhattacharya
Summary: The membrane formation and aggregation properties of α-tocopherol-based cationic gemini lipids were extensively studied with varying polymethylene spacer lengths and the presence of hydroxyl functionalities at the headgroup region. The interaction of these lipids with model phospholipids and plasmid DNA showed that the aggregation behavior is strongly influenced by the length of the spacer and the presence of hydroxyl groups. The study provided a detailed characterization of the membranes formed from these lipids and highlighted the importance of inserting -OH groups at the headgroup region.
Article
Agriculture, Multidisciplinary
Maria L. Sossi, Estela M. Valle, Silvana B. Boggio
Summary: The study compares changes in lipid composition of tomato fruits with different chilling sensitivities, showing membrane fluidity adjustment depending on temperature. Gene expression analysis indicates fatty acid desaturase and DGD synthase genes are differentially expressed in response to cold storage.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Oncology
John A. Vargo, Vitali Moiseenko, Jimm Grimm, Jimmy Caudell, David A. Clump, Ellen Yorke, Jinyu Xue, Yevgeniy Vinogradskiy, Eduardo G. Moros, Panayiotis Mavroidis, Sheena Jain, Issam El Naqa, Lawrence B. Marks, Dwight E. Heron
Summary: This study systematically reviewed the available literature on tumor control probability with SBRT in head and neck cancer patients, finding a dose-response relationship suggesting better local control and possibly improved overall survival with doses of 35 to 45 Gy (in 5 fractions) compared with <30 Gy. It is suggested that SBRT doses equivalent to 5-fraction doses of 40 to 50 Gy are used for retreatment.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Cardiac & Cardiovascular Systems
C. Michael Gibson, John J. P. Kastelein, Adam T. Phillips, Philip E. Aylward, Megan K. Yee, Michal Tendera, Stephen J. Nicholls, Stuart Pocock, Shaun G. Goodman, John H. Alexander, Michael Lincoff, Christoph Bode, Danielle Duffy, Mark Heise, Gail Berman, Sojaita Jenny Mears, Pierluigi Tricoci, Lawrence I. Deckelbaum, P. Gabriel Steg, Paul Ridker, Roxana Mehran
Summary: AEGIS-II is a Phase 3 trial investigating the efficacy and safety of CSL112 compared to placebo among high-risk acute MI participants, aiming to determine whether enhancing cholesterol efflux can reduce the rate of recurrent major adverse cardiovascular events. This study will be the first to formally test this hypothesis.
AMERICAN HEART JOURNAL
(2021)
Article
Medicine, Legal
Lyle D. Burgoon, Harvey J. Clewell, Tony Cox, Wolfgang Dekant, Linda D. Dell, James A. Deyo, Michael L. Dourson, Bernard K. Gadagbui, Philip Goodrum, Laura C. Green, K. Vijayavel, Travis R. Kline, Tamara House-Knight, Michael I. Luster, Therese Manning, Paul Nathanail, Frank Pagone, Katie Richardson, Tiago Severo-Peixe, Anurag Sharma, James S. Smith, Nitin Verma, Jackie Wright
Summary: Many government agencies and expert groups have estimated a safe dose of perfluorooctanoate (PFOA) to protect human health, but the values of these safe doses vary widely. The Steering Committee of the Alliance for Risk Assessment conducted a study to understand and narrow these disparities, and determined that PFOA dose-rates of 10-70 ng/kg-day are protective of human health.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Physics, Atomic, Molecular & Chemical
Micah T. Donor, Jesse W. Wilson, Samantha O. Shepherd, James S. Prell
Summary: The native mass spectrometry analysis of membrane proteins has provided valuable insights into membrane protein-lipid interactions. Gas-phase chemistry factors, including gas-phase basicity and acidity, play a crucial role in the behavior of non-covalent complexes subjected to collision induced dissociation (CID). The study shows that phosphoserine head groups form the strongest bonds with proteins, while glycerophosphocholine head groups form the weakest interactions.
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY
(2021)
Review
Environmental Sciences
A. Ojha, S. Jaiswal, P. Thakur, S. K. Mishra
Summary: Accumulation of heavy metals increases toxic contaminants in soil and the environment, posing significant threats to ecosystems. Bioremediation, using microorganisms to lower/remove toxicity, is an important, cost-effective solution. Alternative methods like nanobioremediation, vermiremediation, and genetically modified microbes have also shown promise.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Soma Roy, Nirmal Chakraborty, Bappa Maiti, Kalappa Muniyappa, Santanu Bhattacharya
Summary: We have investigated the stabilization of higher-order noncanonical G-quadruplex (G4) DNA structures in oncogene promoter regions using newly synthesized nitrogen-containing aromatics conjugated to xanthone moiety. These compounds showed enhanced stability of G4 DNA and selective cytotoxicity for cancer cells. Spectroscopic measurements and melting experiments verified the G4 stabilization effect. These compounds induced the formation of parallel G4 structures even in the absence of added salt. Polymerase stop assay demonstrated the stability of G4 structures in oncogene promoters and the inhibition of DNA synthesis by these compounds. Apoptosis-mediated cell death and cell-cycle arrest in the S phase were observed in cancer cells. Molecular dynamics simulation studies suggested a binding mode involving the stacking of the xanthone core on the G4 DNA plane.
Article
Nanoscience & Nanotechnology
Aishwarya Naik, Krishan Kumar, Niranjan Chatterjee, Santosh K. Misra
Summary: A biocompatible and fluorescently trackable nanosystem, FeNCP, was developed to modulate the GSH pool in cancer cells and enhance the cytotoxic effects of Dox. The combination treatment of FeNCP and Dox showed higher cytotoxicity towards cancer cells compared to normal cells. This nanosystem has the potential for optical detection of GSH and imaging-assisted surgery, in addition to advancing anticancer chemotherapy.
ACS APPLIED BIO MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Niranjan Chatterjee, Santosh Kumar Misra
Summary: A novel biomaterial, MusCAMLR, has been developed to repair mechanically damaged skeletal muscles, which can have a significant impact on the health and lifestyle of athletes, mountaineers, and security personnel. This musculoresponsive polymer-carbon composite establishes a mechanical interaction with muscle cells and supports myotube regeneration, restoring the structural integrity and biochemical parameters of damaged muscles within a short period of 72 hours. In summary, this study demonstrates the potential of smartly passivated nanocarbon in generating an advanced biomaterial system for therapeutic applications.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Subhajit Bhunia, Armando Pena-Duarte, Huifang Li, Hong Li, Mohamed Fathi Sanad, Pranay Saha, Matthew A. . Addicoat, Kotaro Sasaki, T. Amanda Strom, Miguel Jose Yacaman, Carlos R. . Cabrera, Ram Seshadri, Santanu Bhattacharya, Jean-Luc Bredas, Luis Echegoyen
Summary: Designing N-coordinated porous single-atom catalysts (SACs) is a promising approach for enhanced energy conversion. This study reports two efficient SAC systems, Co@rhm-PorBTD and Co@sql-PorBTD, based on Co(II)-porphyrin/ [2,1,3]-benzothiadiazole (BTD) covalent organic frameworks (COFs), for O2 electrocatalysis. Experimental results show that these COFs outperform commercial Pt/C by a large margin. The design and electrochemical performance of these COFs offer a pyrolysis-free bottom-up approach that avoids creating random atomic sites or unpredictable structural features.
Article
Engineering, Electrical & Electronic
Alka Mishra, Surekha Bhusnur, Santosh Mishra
Summary: In the last 20 years, most human deaths have been caused by heart failure. ECG is an important clinical test for diagnosing dangerous cardiac electrical disturbances. Generating an artificial ECG signal that reflects the characteristics of a real ECG signal is challenging due to noise and artifacts. This paper presents a method of modeling an ECG signal and classifies it using different techniques. The tree algorithm shows the best performance in classifying abnormal and normal sinus rhythms, eliminating the need for pre-processing and traditional feature extraction techniques.
CIRCUITS SYSTEMS AND SIGNAL PROCESSING
(2023)
Review
Chemistry, Physical
Suveksha Tamang, Sadhna Rai, Rabina Bhujel, Nayan Kamal Bhattacharyya, Bibhu Prasad Swain, Joydeep Biswas
Summary: Graphene and its derivatives, such as graphene oxide (GO) and reduced graphene oxide (rGO), have been widely used in various applications due to their highly exploitable properties. The introduction of metal oxides (MOs) to the surface of these nanoparticles has been shown to significantly enhance their properties. This review article discusses various synthesis methods for GO and rGO, including a green approach for reducing GO to rGO. The article also discusses the properties of graphene and its derivatives, as well as their application in supercapacitors and catalysis.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Article
Engineering, Electrical & Electronic
Suveksha Tamang, Sadhna Rai, Manas Kumar Mondal, Nayan Kamal Bhattacharyya, Bibhu Prasad Swain, Joydeep Biswas
Summary: A microwave-assisted green reduction approach using Artemisia vulgaris plant leaf extract was developed to reduce graphene oxide (GO) to reduced graphene oxide (rGO). The reduction parameters were optimized to achieve the highest specific capacitance (C-S) value. The study compared the properties of GO and rGO, including structure, morphology, vibration, optics, bonding, networks, and electrochemical properties, for supercapacitor applications. The potential of Artemisia vulgaris extract to reduce GO into rGO was demonstrated, and an optimal volume of the extract was identified. The rGO samples showed improved electrochemical performance compared to GO.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
(2023)
Article
Chemistry, Multidisciplinary
S. Umesh, S. Sarkar, S. Bera, P. Moitra, S. Bhattacharya
Summary: A new hydrogel was developed by mixing 5'-guanosine monophosphate disodium salt and 1,4,5,8-naphthalene tetracarboxylic acid tetra potassium salt. The hydrogel showed excellent stability and pH-responsive properties. It was used for the encapsulation and delivery of an anticancer drug, and demonstrated high drug loading capacity and controlled release capabilities. In vivo studies showed significant regression of tumor volume after administration of the drug-loaded hydrogel.
MATERIALS TODAY CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Soma Roy, Bappa Maiti, Nilanjan Banerjee, Mangesh H. Kaulage, Kalappa Muniyappa, Subhrangsu Chatterjee, Santanu Bhattacharya
Summary: Xanthone is a significant scaffold for designing cytotoxic agents against cancer cells by stabilizing G-quadruplex nucleic acids. We synthesized xanthone-based derivatives with various side-arm substituents that showed selectivity for G4 DNA over dsDNA, verified through biophysical experiments. These compounds exhibit end-stacking mode of binding with G4 DNA and induce conformational changes in flanking nucleotides, suggesting their potential as potent anti-cancer agents.
ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Dipen Biswakarma, Nilanjan Dey, Santanu Bhattacharya
Summary: In this study, a stable and soft nanocomposite hydrogel comprised of a pyrene-based chiral amphiphile with an amino acid (l-phenylalanine) core and oligo-oxyethylene hydrophilic chains and graphene oxide (GO) was developed. The nanocomposite hydrogel exhibited superior mechanical stiffness and thixotropic properties compared to the native hydrogels. It was also used for optical sensing of biogenic polyamine and removal of toxic organic dyes from aqueous media.
Article
Materials Science, Multidisciplinary
Sadhna Rai, Suveksha Tamang, Aditya Chettri, Rabina Bhujel, Manas Kumar Mondal, Pradipta Ghosh, Nayan Kamal Bhattacharyya, Bibhu Prasad Swain, Joydeep Biswas
Summary: A cost-efficient, eco-friendly and simple method was adopted to synthesize cobalt oxide/reduced graphene oxide (rGO) nanocomposite (NC) using an extract of Eupatorium glandulosum Kunth. Various analysis techniques, including SEM, TEM, ATR-FTIR, Raman spectroscopy, XRD, and XPS, were used to characterize the morphology, functional groups, structure, and oxidation state of cobalt oxide in the NC. The electrochemical properties of the NC were also studied using Tafel and EIS.
BULLETIN OF MATERIALS SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Dipen Biswakarma, Nilanjan Dey, Santanu Bhattacharya
Summary: A pyrene-based fluorogenic amphiphilic probe (1) was synthesized to form an injectable hydrogel in water, which enables sustainable delivery of two anticancer drugs, DOX and MT, under thermoresponsive conditions. The drug-loaded hydrogel showed a substantial difference in release rates at 25 and 37 degrees C, with cumulative releases of approximately 80% and 70% for DOX and MT, respectively, over 72 hours. The release of drug molecules followed zero-order kinetics and non-Fickian diffusion pathways. The stability of the hydrogel against proteinase enzymes suggests its potential for targeted and sustainable drug release in vivo. As expected, DOX-loaded hydrogels exhibited higher efficacy in killing cancer cells compared to free DOX.
JOURNAL OF CHEMICAL SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Sayan Umesh, Sayan Bera, Santanu Bhattacharya
Summary: This study develops a chiral organogel with thermo-reversible properties, forming fibrillar networks and 2D sheets. Circular dichroism studies reveal aggregation-induced chirality with circularly polarized luminescence. The 2D sheets exhibit enhanced piezoelectric responses compared to those from the fibrillar network. Introducing an electron-deficient dopant molecule leads to a charge-transfer complex and modulates the piezoelectric response.
Article
Chemistry, Multidisciplinary
Santosh K. Misra, Mao Ye, Parikshit Moitra, Ketan Dighe, Abhinav Sharma, Enrique A. Daza, Aaron S. Schwartz-Duval, Fatemeh Ostadhossein, Dipanjan Pan
Summary: In this study, we propose an environmentally friendly technology using a graphene-based carbon allotrope surface to remediate genetic materials in hospital waste. Extensive characterization has shown that this approach has great potential in large-scale hospital waste disposal.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Organic
Faiza Diaba, Gisela Trenchs
Summary: The first violet light-mediated synthesis of gamma- and delta-lactams from N-alkenyl trichloroacetamides is reported in this paper. The reactions are conducted in tetrahydrofuran or 2-methyltetrahydrofuran as the sole solvent without catalysts or additives, under non-anhydrous conditions in an air atmosphere where the solvent serves as the radical initiator.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Feroze Hussain, Sajjad Ahmed, Ashiq Hussain Padder, Qazi Naveed Ahmed
Summary: This study reports a novel and efficient one-pot synthesis method for mixed phosphorotrithioates, which does not require supplementary additives and shows broad applicability.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Hyunjin Oh, Ikyon Kim
Summary: A new 1,2,4-triazole-pyrrolo[1,2-a]pyrazine hybrid system, 6-acylpyrrolo[1,2-a][1,2,4]triazolo[5,1-c]pyrazine, was synthesized using a catalyst-free method. This method involved sequential exposure of pyrrole-2-carbonitrile-derived substrates to DMF-DMA and acyl hydrazide, resulting in the formation of acylated pyrazine and 1,2,4-triazole rings, enabling the installation of various substituents at specific positions on the core skeleton.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Ming Yan, Si-fan Wang, Yong-po Zhang, Jin-zhong Zhao, Zhuo Tang, Guang-xun Li
Summary: Here we developed an efficient photocatalytic approach for the convenient preparation of sulfinamides. The reaction allows for the gram-scale preparation of sulfinamides and the one-pot synthesis of various sulfonyl amides.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Farzaneh Bandehali-Naeini, Zahra Tanbakouchian, Noushin Farajinia-Lehi, Nicolas Mayer, Morteza Shiri, Martin Breugst
Summary: Two tandem catalytic systems were developed for the synthesis of novel 3,4-disubstituted maleimides using the same Ugi adducts. Different maleimide structures can be synthesized using either Pd or Cu catalysis.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Tanya Raghava, Anjan Chattopadhyay, Subhadeep Banerjee, Nivedita Sarkar
Summary: Amine substitution of two ortho fluorine atoms of tetrafluoroterephthalonitrile through SNAr chemistry is easily achievable. But further fluorine substitution is only possible under forcing conditions, yielding valuable fluorophores for bioimaging.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Review
Chemistry, Organic
Anju Chadha, Santosh Kumar Padhi, Selvaraj Stella, Sowmyalakshmi Venkataraman, Thangavelu Saravanan
Summary: Alcohol dehydrogenases are enzymes that use cofactors for oxidation or reduction reactions of alcohols or carbonyl compounds. They are utilized in green chemistry and have applications in the production of pharmaceuticals. Recombinant enzymes have solved the challenge of producing purified enzymes in large quantities. Engineered alcohol dehydrogenases have been used in asymmetric synthesis in industry. Various methods have been established for regenerating expensive cofactors to make the enzymatic process more efficient and economically viable.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
