Article
Chemistry, Multidisciplinary
Kesatebrhan Haile Asressu, Chieh-Kai Chan, Cheng-Chung Wang
Summary: A facile and green one-pot synthetic method was developed for substituted 1,3,5-triaryl-1,5-diketones with several advantages including a broad substrate scope, high yield, shorter reaction time, and environmentally friendly properties.
Article
Chemistry, Organic
Simra Faraz, Sabina Yashmin, Mayura Dilip Marathe, Abu Taleb Khan
Summary: In this study, a one-pot three-component reaction was employed to synthesize 2,4-diarylquinolines using arylamine, aryl aldehyde, and aryl acetylene and 30 mol% p-toluenesulfonic acid monohydrate (p-TSA center dot H2O) as a catalyst at 110 degrees C temperature under solvent-free conditions. The notable features of this protocol include the absence of a metal catalyst, additive, solvent, and inert atmospheric reaction conditions, as well as good yield, wide substrate scope, and shorter reaction time.
TETRAHEDRON LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Rayenne Redjemia, Abdeslem Bouzina, Yousra Ouafa Bouone, Achraf Mansouri, Rania Bahadi, Malika Berredjem
Summary: The development of novel, clean, and efficient methods for the preparation of compounds is a major research focus in organic chemistry. In this study, copper bromide was used as a heterogeneous catalyst for the synthesis of beta-enaminone derivatives through condensation reactions. The desired products were obtained with high yields and short reaction times.
RESEARCH ON CHEMICAL INTERMEDIATES
(2022)
Article
Chemistry, Organic
Mohinuddin Khan Imon, Readul Islam, Pran G. Karmaker, Pijush K. Roy, Kee-In Lee, Harendra N. Roy
Summary: A green and efficient method for synthesizing biologically active xanthene derivatives has been developed using a three-component reaction mediated by 2-aminophenol. The method offers advantages such as short reaction time, easy product isolation, non-toxic catalyst, and metal-free process.
SYNTHETIC COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Himanshu Kumar Singh, Arsala Kamal, Savita Kumari, Suresh Kumar Maury, Ambuj Kumar Kushwaha, Vandana Srivastava, Sundaram Singh
Summary: The mild, efficient, solvent-free, metal-free, and operationally simple visible light-promoted multicomponent reaction using Eosin Y as a photocatalyst provides a variety of fused imidazoheterocycles with good to excellent yields. The approach uses readily accessible and economical starting materials under ambient conditions, with a broad substrate scope and compatibility with several functional groups.
Article
Chemistry, Organic
Long-Long Su, Yi-Wen Zheng, Wen-Guang Wang, Bin Chen, Xiang-Zhu Wei, Li-Zhu Wu, Chen-Ho Tung
Summary: This paper describes an approach for synthesizing quinolines either from N-alkyl anilines or from anilines and aldehydes. A dual-catalyst system consisting of a photocatalyst and a proton reduction cocatalyst is used. Without the need for sacrificial oxidant and under mild conditions, the reactions can yield quinolines with excellent yields and produce H2 as a byproduct.
Article
Chemistry, Organic
Gnanaoli Karthiyayini, Deepan Babu Rajkumar, Subbiah Nagarajan, Vellaisamy Sridharan, C. Uma Maheswari
Summary: An environmentally friendly and efficient three-component synthesis of tetrasubstituted pyrroles was developed through a nucleophilic attack followed by Michael addition and intramolecular cyclization. The reaction exhibited high atom economy, excellent yields, and scalability compared to previous methods. The wide range of primary amines and different substituted f3-nitrostyrenes and dialkyl acetylenedicarboxylates further demonstrated the versatility of this approach.
Article
Chemistry, Physical
Serena Traboni, Emiliano Bedini, Alfredo Landolfi, Giulia Vessella, Alfonso Iadonisi
Summary: A solvent-free method has been developed for regioselective functionalization of carbohydrate polyols with tosyl group, using cheap reagents and simple experimental procedures, resulting in selective functionalization of a specific saccharide site in a short period of time.
Article
Chemistry, Applied
Siyu Zhang, Joseph R. Hyatt, Casimir C. Akoh
Summary: In this study, a multi-functional galloylated structured lipid DOGG was successfully synthesized using immobilized food grade Candida antarctica lipase B. The reaction conditions were optimized and the structure of the product was confirmed. The enzyme showed good reusability and DOGG has potential applications as an antioxidant and nutraceutical.
Article
Chemistry, Multidisciplinary
Seyed Ali Mousavi-Mashhadi, Kimia Hoseinzade, Ali Shiri
Summary: A novel heterogeneous catalyst, natural halloysite@Si(CH2)(3)NH2@Cu(acac)(2), was synthesized and characterized in this study. The catalytic activity of the catalyst in the multicomponent A(3)-coupling reaction was also evaluated.
RESEARCH ON CHEMICAL INTERMEDIATES
(2023)
Article
Chemistry, Multidisciplinary
Wenjing Li, Shun Li, Lihua Luo, Yicen Ge, Jiaqi Xu, Xueli Zheng, Maolin Yuan, Ruixiang Li, Hua Chen, Haiyan Fu
Summary: The catalyst-free oxidative cleavage of (Z)-triaryl-substituted alkenes with a pyridyl motif has been developed under blue LED irradiation at room temperature, generating pharmaceutically useful 2-acyl pyridines. Studies suggest that singlet oxygen and superoxide anion are the reactive oxidants, with the generation mechanism of singlet oxygen correlated to the photophysical properties of the substrate.
Article
Chemistry, Inorganic & Nuclear
Yoshitaka Mizuno, Koji Miyake, Shunsuke Tanaka, Norikazu Nishiyama, Choji Fukuhara, Chang Yi Kong
Summary: OSDA/solvent-free synthesis of zeolites is suitable for commercialization due to low environmental impact and cost efficiency. This study successfully synthesized various types of zeolites by adjusting Si/Al ratios and crystallization temperature, showing that zeolites with high T atom density are more stable at higher crystallization temperatures. This work establishes a clear guideline for the OSDA/solvent-free synthesis of zeolites by revealing the correlation between Si/Al ratio and crystallization temperature.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2021)
Article
Polymer Science
Satyaranjan Behera, Braja N. Patra
Summary: The alum doped nanopolyaniline (NDPANI) is developed as an efficient and reusable green catalyst for synthesis of beta-amino carbonyl compounds through Mannich type reaction. It offers advantages of being inexpensive, reusability, easy preparation, and stability, representing an advanced alternative to established methods with solvent-free condition, mild reaction condition, clean reaction profile, and simple workup.
Review
Chemistry, Physical
Agnieszka Kornas, Joanna E. Olszowka, Petr Klein, Veronika Pashkova
Summary: The current paramount challenge of chemical technology lies in meeting ecological sustainability requirements, with solvent-free synthesis methods showing great potential in reducing water consumption and increasing production efficiency.
Article
Chemistry, Multidisciplinary
Shubham R. Bankar, Sambhaji S. Ghadge, Vrushali H. Jadhav
Summary: In this study, a simple, cheap, eco-friendly, and reusable glucose-based carbonaceous material (GCM) was synthesized as a catalyst for the synthesis of alpha-ketoamides. The GCM catalyst showed high catalytic activity under green and economical reaction conditions, leading to good yields.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Floriana Vindigni, Stefano Dughera, Francesco Armigliato, Anna Chiorino
MONATSHEFTE FUR CHEMIE
(2016)
Article
Chemistry, Multidisciplinary
Margherita Barbero, Silvano Cadamuro, Stefano Dughera
Article
Chemistry, Multidisciplinary
Margherita Barbero, Giuseppina Cerrato, Enzo Laurenti, Sebastiano Zanol, Stefano Dughera
Article
Chemistry, Organic
Margherita Barbero, Stefano Dughera
ORGANIC & BIOMOLECULAR CHEMISTRY
(2018)
Article
Chemistry, Organic
Margherita Barbero, Stefano Dughera
Article
Chemistry, Organic
Margherita Barbero, Stefano Dughera, Sara Alberti, Giovanni Ghigo
Article
Chemistry, Physical
Pierpaolo Morgante, Stefano Dughera, Giovanni Ghigo
JOURNAL OF PHYSICAL CHEMISTRY A
(2019)
Article
Chemistry, Organic
Margherita Barbero, Domenica Marabello, Stefano Dughera, Tiziana Sicari, Achille Antenucci, Giovanni Ghigo
Article
Chemistry, Organic
Achille Antenucci, Margherita Barbero, Stefano Dughera, Giovanni Ghigo
Review
Chemistry, Multidisciplinary
Achille Antenucci, Stefano Dughera, Polyssena Renzi
Summary: This review discusses the synthesis of organic chiral catalysts, presents a classification of catalyst scaffolds based on their E factor, and proposes the global E factor (E-G factor) as a new green chemistry metric.
Article
Chemistry, Physical
Achille Antenucci, Matteo Bonomo, Giovanni Ghigo, Lorenzo Gontrani, Claudia Barolo, Stefano Dughera
Summary: This paper investigates the behaviors of arenediazonium tetrafluoroborates in new halide salts/polyol-based DESs, revealing a relatively fast reduction reaction that depends on the electronic effects of substituents. The study aims at elucidating the involved mechanism through computational analysis and experimental approaches.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Organic
Achille Antenucci, Monica Messina, Massimiliano Bertolone, Marco Bella, Armando Carlone, Riccardo Salvio, Stefano Dughera
Summary: The text discusses the use of Solketal, a chiral acetonide of glycerol, in the design of a novel chiral phosphate sodium salt for catalytic applications. The racemate and enantiomers of the substrate can be prepared economically and commercially, allowing for the synthesis of both enantiomers of the final catalyst with simple procedures in high yield. The application of this novel catalyst in a solventless protocol for cyanohydrin synthesis from aldehydes is also presented to demonstrate its usefulness.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Giovanni Ghigo, Matteo Bonomo, Achille Antenucci, Chiara Reviglio, Stefano Dughera
Summary: Deep eutectic solvent (DES)-like mixtures based on glycerol and different halide organic and inorganic salts have been successfully used as new media for copper-free halodediazoniation of arenediazonium salts. The reactions are conducted without the need for metal-based catalysts, at room temperature, and in a short period of time. Pure target products are obtained without the requirement of chromatographic separation. The solvents have been fully characterized and a computational study has been presented in order to understand the reaction mechanism.
Article
Biochemistry & Molecular Biology
Achille Antenucci, Matteo Bonomo, Simone Ghinato, Marco Blangetti, Stefano Dughera
Summary: This study utilized a chiral glycerol derivative to design a new deep eutectic solvent, demonstrating its effectiveness in synthesis and potential as a green alternative.
Article
Chemistry, Multidisciplinary
Achille Antenucci, Francesco Marra, Stefano Dughera
Summary: A chiral heterogeneous catalyst proved to be efficient in a three-component asymmetric Passerini protocol conducted in a deep eutectic solvent. The reaction conditions were mild and environmentally-friendly, with excellent enantioselectivity. The catalyst was easily recovered and reused without any loss in catalytic activity.
Article
Chemistry, Organic
Faiza Diaba, Gisela Trenchs
Summary: The first violet light-mediated synthesis of gamma- and delta-lactams from N-alkenyl trichloroacetamides is reported in this paper. The reactions are conducted in tetrahydrofuran or 2-methyltetrahydrofuran as the sole solvent without catalysts or additives, under non-anhydrous conditions in an air atmosphere where the solvent serves as the radical initiator.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Feroze Hussain, Sajjad Ahmed, Ashiq Hussain Padder, Qazi Naveed Ahmed
Summary: This study reports a novel and efficient one-pot synthesis method for mixed phosphorotrithioates, which does not require supplementary additives and shows broad applicability.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Hyunjin Oh, Ikyon Kim
Summary: A new 1,2,4-triazole-pyrrolo[1,2-a]pyrazine hybrid system, 6-acylpyrrolo[1,2-a][1,2,4]triazolo[5,1-c]pyrazine, was synthesized using a catalyst-free method. This method involved sequential exposure of pyrrole-2-carbonitrile-derived substrates to DMF-DMA and acyl hydrazide, resulting in the formation of acylated pyrazine and 1,2,4-triazole rings, enabling the installation of various substituents at specific positions on the core skeleton.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Ming Yan, Si-fan Wang, Yong-po Zhang, Jin-zhong Zhao, Zhuo Tang, Guang-xun Li
Summary: Here we developed an efficient photocatalytic approach for the convenient preparation of sulfinamides. The reaction allows for the gram-scale preparation of sulfinamides and the one-pot synthesis of various sulfonyl amides.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Farzaneh Bandehali-Naeini, Zahra Tanbakouchian, Noushin Farajinia-Lehi, Nicolas Mayer, Morteza Shiri, Martin Breugst
Summary: Two tandem catalytic systems were developed for the synthesis of novel 3,4-disubstituted maleimides using the same Ugi adducts. Different maleimide structures can be synthesized using either Pd or Cu catalysis.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Tanya Raghava, Anjan Chattopadhyay, Subhadeep Banerjee, Nivedita Sarkar
Summary: Amine substitution of two ortho fluorine atoms of tetrafluoroterephthalonitrile through SNAr chemistry is easily achievable. But further fluorine substitution is only possible under forcing conditions, yielding valuable fluorophores for bioimaging.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Review
Chemistry, Organic
Anju Chadha, Santosh Kumar Padhi, Selvaraj Stella, Sowmyalakshmi Venkataraman, Thangavelu Saravanan
Summary: Alcohol dehydrogenases are enzymes that use cofactors for oxidation or reduction reactions of alcohols or carbonyl compounds. They are utilized in green chemistry and have applications in the production of pharmaceuticals. Recombinant enzymes have solved the challenge of producing purified enzymes in large quantities. Engineered alcohol dehydrogenases have been used in asymmetric synthesis in industry. Various methods have been established for regenerating expensive cofactors to make the enzymatic process more efficient and economically viable.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
