期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 9, 期 1, 页码 66-69出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0ob00693a
关键词
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资金
- AgenceNationale de la Recherche [ANR-09-BLAN-0081-01]
- La Region Haute-Normandie via
- Institut Universitaire de France (IUF)
The synthesis and preliminary bio-conjugation studies of a novel water-soluble red-emitting di-styryl BODIPY dye are disclosed. Aggregation behaviour of this compound under physiological conditions was suppressed by specific introduction of a di-sulfonated peptide-based linker at the meso phenyl substituent, sultonated styryl arms and short polyethyleneglycol chains at the boron center. Thus, a good quantum yield of 22% in PBS for this red-emitting BODIPY was obtained. Introduction of an activated ester function enabled successful bio-conjugation to monoclonal antibodies and proteins.
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