Article
Multidisciplinary Sciences
Caiyou Chen, Jonas C. Peters, Gregory C. Fu
Summary: The study describes a method for enantioselective substitution of unactivated alkyl electrophiles using a copper-based photoinduced catalyst system, expanding the scope of enantioselective N-substitution reactions to include unactivated electrophiles.
Review
Chemistry, Multidisciplinary
Suparna Dutta, Trisha Bhattacharya, Finn J. Geffers, Marcel Buerger, Debabrata Maiti, Daniel B. Werz
Summary: This review comprehensively describes the versatile roles of carboxylic acids in Pd-catalysed C-H activation reactions, highlighting their significance in the pharmaceutical and agrochemical industries. The review also discusses recent mechanistic perspectives and strategies, serving as educational resources for future research.
Article
Chemistry, Organic
Cong Lv, Dan Liu, Tegshi Muschin, Chaolumen Bai, Agula Bao, Yong-Sheng Bao
Summary: In this study, a general method for the synthesis of urea derivatives and carbamates through copper-catalyzed C-C bond cleavage of amides at room temperature is presented. The proposed catalytic process involves a resonant six-membered N,O-chelated copper cycle and superoxide radical. This method allows for the cleavage of C-C bonds in common substrates with multiple reactive sites, making it of great interest in organic synthesis, the pharmaceutical industry, and the agrochemical industry.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Multidisciplinary
Kenshiro Hitoshio, Hiroki Yamagishi, Jun Shimokawa, Hideki Yorimitsu
Summary: A diverse range of aryl chlorides underwent silylation using sodium silylsilanolate reagents in the presence of a Ni(cod)(2) catalyst complexed with phosphine ligands. The reaction conditions were mild and allowed for silylation of various aryl chlorides, including functionalised drug molecules.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Organic
Jia-Sheng Ouyang, Xinhuan Zhang, Bendu Pan, Haobin Zou, Albert S. C. Chan, Liqin Qiu
Summary: A highly efficient and easy-to-operate solvent-free Buchwald-Hartwig amination method was developed using a robust N-heterocyclic carbene-palladium complex, with catalyst amount as low as 0.05 wt %. The method was successfully applied to the synthesis of commercial pharmaceuticals and candidate drugs with high yields.
Article
Chemistry, Organic
Charu Sharma, Avinash K. Srivastava, Deepak Sharma, Raj K. Joshi
Summary: This article presents a significantly upgraded Ullmann reaction for C-N cross couplings of aryl/alkyl chlorides. The method works in completely opposite conditions and is significantly influenced by various 3d transition metals, resulting in improved reaction time and catalytic activity.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Multidisciplinary
Yanwei Cao, Yang Huang, Lin He
Summary: In this study, a step- and atom-economic synthesis of N-Boc amines from readily available substrates was reported. The catalytic system showed unique selectivity for N-Boc amines in good yields and demonstrated potential application prospects in industrial syntheses. Mechanistic investigations revealed that gold catalyzed the reaction and copper acted as an electron transfer mediator in the catalytic cycle.
Article
Chemistry, Physical
Sanqi Liang, Shunli Shi, Shunmin Ding, Weiming Xiao, Herong Wang, Shuhua Wang, Rong Zeng, Chao Chen, Weiguo Song
Summary: A novel mesoporous organic polymer, POP-Phen-E, was synthesized as a transition-metal-free catalyst for the direct activation of aromatic C-H bonds. The catalytic activity of POP-Phen-E is significantly higher than that of the corresponding homogeneous catalyst, attributed to the introduction of electron-donating groups and the enhancement of the reactants' adsorption capacity.
CATALYSIS SCIENCE & TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Lanfeng Wei, Yu Wei, Jinli Zhang, Liang Xu
Summary: This research explores a visible-light-induced oxidative dehydrogenative process using an organoboron compound as the photocatalyst and molecular oxygen as the sole oxidant. This approach successfully accessed an array of N-heterocycles under metal-free mild conditions, in good to excellent yields.
Article
Chemistry, Multidisciplinary
Hong-Yan Hao, Shao-Jie Lou, Shuang Wang, Kun Zhou, Qiu-Zi Wu, Yang-Jie Mao, Zhen-Yuan Xu, Dan-Qian Xu
Summary: An efficient Pd-catalysed beta-C(sp(3))-H arylation was developed for the diverse native amides with aryl iodides. This protocol shows a broad substrate scope and good functional group tolerance, demonstrated by gram-scale synthesis and the synthesis of several bioactive molecules.
CHEMICAL COMMUNICATIONS
(2021)
Review
Chemistry, Physical
Pravya P. Nair, Rose Mary Philip, Gopinathan Anilkumar
Summary: The importance of fluorine in the pharmaceutical and agrochemical industry has led to increased attention on methods to introduce fluorine into compounds. Nickel catalysts have shown promising applications in introducing various fluorinated functionalities, and this review comprehensively covers the strategies and mechanistic analyses involved in nickel-catalysed fluoromethylation reactions up to 2021.
CATALYSIS SCIENCE & TECHNOLOGY
(2021)
Article
Chemistry, Organic
Qiang Wang, Zilong Yan, Dong Xing
Summary: We report a nickel(0)-catalyzed linear-selective hydroarylation reaction using a bifunctional temporary directing group strategy. Excellent linear selectivity is achieved through imino-assisted six-membered metallacycle formation.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Review
Chemistry, Organic
Yingying Tian, Le'an Hu, Yuan-Zheng Wang, Xumu Zhang, Qin Yin
Summary: Transition-metal-catalysed asymmetric reductive amination is a direct method for accessing chiral amines, converting carbonyl compounds and ammonia or amines into drug-relevant compounds in one pot. Recent progress has been made in homogeneous transition-metal-catalysed ARA reactions with H-2 or other hydride sources, but challenges and potential still exist in this field.
ORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Physical
Ya-Qian Zhang, Lingfei Hu, Liyan Yuwen, Gang Lu, Qing-Wei Zhang
Summary: A nickel-catalyzed hydrosulfenation reaction has been developed to efficiently synthesize enantioenriched sulfoxides, which have broad applications in drug synthesis and catalysis.
Article
Multidisciplinary Sciences
N. Ian Rinehart, Rakesh K. Saunthwal, Joel Wellauer, Andrew F. Zahrt, Lukas Schlemper, Alexander S. Shved, Raphael Bigler, Serena Fantasia, Scott E. Denmark
Summary: This study presents a machine-learning tool that accelerates the identification of reaction conditions for palladium-catalyzed carbon-nitrogen couplings. The tool actively learns a large scope of reactions through a systematic experimental design process and demonstrates good performance in predicting new substrate pairings.
Article
Biochemistry & Molecular Biology
Aditya Kapil Valiveti, Uma M. Bhalerao, Jyotiranjan Acharya, Hitendra N. Karade, Badri Narayan Acharya, G. Raviraju, Anand K. Halve, Mahabir Parshad Kaushik
BIOORGANIC & MEDICINAL CHEMISTRY
(2015)
Article
Chemistry, Multidisciplinary
Nilesh B. Shelke, Ramrao Ghorpade, Ajay Pratap, Vijay Tak, B. N. Acharya
Article
Biochemistry & Molecular Biology
Hitendra N. Karade, G. Raviraju, B. N. Acharya, Aditya Kapil Valiveti, Uma Bhalerao, Jyotiranjan Acharya
BIOORGANIC & MEDICINAL CHEMISTRY
(2016)
Article
Chemistry, Medicinal
Badri Narayan Acharya, Deepika Saraswat, Mugdha Tiwari, Asish Kumar Shrivastava, Ramarao Ghorpade, Saroj Bapna, Mahabir Parshad Kaushik
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2010)
Article
Chemistry, Medicinal
Hitendra N. Karade, B. N. Acharya, Manisha Sathe, M. P. Kaushik
MEDICINAL CHEMISTRY RESEARCH
(2008)
Article
Chemistry, Medicinal
Badri Narayan Acharya, Deepika Saraswat, Mahabir Parshad Kaushik
MEDICINAL CHEMISTRY RESEARCH
(2008)
Article
Chemistry, Medicinal
Badri N. Acharya, G. B. Dharma Rao, Deo Kumar, Pravin Kumar, Mahabir P. Kaushik
MEDICINAL CHEMISTRY RESEARCH
(2015)
Article
Chemistry, Organic
Sanjeev K. Verma, B. N. Acharya, M. P. Kaushik
Article
Chemistry, Organic
G. B. Dharma Rao, B. N. Acharya, S. K. Verma, M. P. Kaushik
TETRAHEDRON LETTERS
(2011)
Article
Chemistry, Multidisciplinary
Sanjeev K. Verma, B. N. Acharya, Ramarao Ghorpade, Ajay Pratap, M. P. Kaushik
Article
Multidisciplinary Sciences
Amrita Saha, Badri Narayan Acharya, Raj Priya, Nagesh K. Tripathi, Ambuj Shrivastava, M. Kameswara Rao, Pooja Kesari, Manju Narwal, Shailly Tomar, Sameer S. Bhagyawant, Manmohan Parida, Paban Kumar Dash
SCIENTIFIC REPORTS
(2018)
Article
Chemistry, Multidisciplinary
RamaRao Ghorpade, Deo Kumar, Sabita Nayak, Badri Narayan Acharya
MONATSHEFTE FUR CHEMIE
(2019)
Article
Infectious Diseases
Kavita Yadav, Sunil Dhiman, B. N. Acharya, Rama Rao Ghorpade, Devanathan Sukumaran
PLOS NEGLECTED TROPICAL DISEASES
(2019)
Article
Chemistry, Multidisciplinary
Badri Narayan Acharya, RamaRao Ghorpade, Kshetra Pal Singh, Deo Kumar, Sabita Nayak
Summary: This study synthesized a series of piperazine-triazole derivatives and found that a molecule based on benzonitrile piperazine triazole scaffold showed good tissue relaxation and blocking activity on the neurotransmitter ACh in ex vivo experiment.
MONATSHEFTE FUR CHEMIE
(2021)
Article
Chemistry, Organic
Faiza Diaba, Gisela Trenchs
Summary: The first violet light-mediated synthesis of gamma- and delta-lactams from N-alkenyl trichloroacetamides is reported in this paper. The reactions are conducted in tetrahydrofuran or 2-methyltetrahydrofuran as the sole solvent without catalysts or additives, under non-anhydrous conditions in an air atmosphere where the solvent serves as the radical initiator.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Feroze Hussain, Sajjad Ahmed, Ashiq Hussain Padder, Qazi Naveed Ahmed
Summary: This study reports a novel and efficient one-pot synthesis method for mixed phosphorotrithioates, which does not require supplementary additives and shows broad applicability.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Hyunjin Oh, Ikyon Kim
Summary: A new 1,2,4-triazole-pyrrolo[1,2-a]pyrazine hybrid system, 6-acylpyrrolo[1,2-a][1,2,4]triazolo[5,1-c]pyrazine, was synthesized using a catalyst-free method. This method involved sequential exposure of pyrrole-2-carbonitrile-derived substrates to DMF-DMA and acyl hydrazide, resulting in the formation of acylated pyrazine and 1,2,4-triazole rings, enabling the installation of various substituents at specific positions on the core skeleton.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Ming Yan, Si-fan Wang, Yong-po Zhang, Jin-zhong Zhao, Zhuo Tang, Guang-xun Li
Summary: Here we developed an efficient photocatalytic approach for the convenient preparation of sulfinamides. The reaction allows for the gram-scale preparation of sulfinamides and the one-pot synthesis of various sulfonyl amides.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Farzaneh Bandehali-Naeini, Zahra Tanbakouchian, Noushin Farajinia-Lehi, Nicolas Mayer, Morteza Shiri, Martin Breugst
Summary: Two tandem catalytic systems were developed for the synthesis of novel 3,4-disubstituted maleimides using the same Ugi adducts. Different maleimide structures can be synthesized using either Pd or Cu catalysis.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Tanya Raghava, Anjan Chattopadhyay, Subhadeep Banerjee, Nivedita Sarkar
Summary: Amine substitution of two ortho fluorine atoms of tetrafluoroterephthalonitrile through SNAr chemistry is easily achievable. But further fluorine substitution is only possible under forcing conditions, yielding valuable fluorophores for bioimaging.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Review
Chemistry, Organic
Anju Chadha, Santosh Kumar Padhi, Selvaraj Stella, Sowmyalakshmi Venkataraman, Thangavelu Saravanan
Summary: Alcohol dehydrogenases are enzymes that use cofactors for oxidation or reduction reactions of alcohols or carbonyl compounds. They are utilized in green chemistry and have applications in the production of pharmaceuticals. Recombinant enzymes have solved the challenge of producing purified enzymes in large quantities. Engineered alcohol dehydrogenases have been used in asymmetric synthesis in industry. Various methods have been established for regenerating expensive cofactors to make the enzymatic process more efficient and economically viable.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)