Article
Chemistry, Multidisciplinary
Mian Wang, Xi Mao, Jingye Liu, Bite Deng, Shuai Deng, Shaohong Jin, Wang Li, Jiang Gong, Renhua Deng, Jintao Zhu
Summary: In this study, a facile and versatile method was developed to prepare anisotropic mesoporous carbon microparticles (MCMPs) through self-assembly and self-templated direct carbonization. The method allows for in situ growth and decoration of functional species in the continuous phase, resulting in MCMPs with unique structures and shapes. These MCMPs have important applications in various fields.
Article
Chemistry, Multidisciplinary
Chaorong Wang, Zhencheng Lai, Hujun Xie, Sunliang Cui
Summary: This study demonstrated the use of triazenyl alkynes as versatile building blocks in multicomponent reactions, leading to the synthesis of beta-amino amides with high diastereoselectivity and structural diversity. The bifunctionality of triazenyl alkynes, acting as both C2 fragment and directing group, played a crucial role in achieving the desired outcomes. Furthermore, the triazenyl group allowed for diverse late-stage transformations, opening up new possibilities for building block discovery and rational design of MCRs.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Polymer Science
Aaron A. Burkey, Danyon M. Fischbach, Charlotte M. Wentz, Kathryn L. Beers, Lawrence R. Sita
Summary: A general synthetic strategy is reported for producing various phenyl-group-terminated polyethenes and poly(alpha-olefins), which can be transformed into different telechelic polyolefins through postpolymerization reactions. These materials serve as building blocks for polyolefin-based synthetic polymers, as demonstrated by the syntheses of well-defined polyolefin-polyester di- and triblock copolymers.
Article
Polymer Science
Xueting Wan, Jian Jiang, Yanyan Tu, Siyuan Xu, Jing Li, Huanjun Lu, Zhikai Li, Lianhu Xiong, Xiaohong Li, Youliang Zhao, Yingfeng Tu
Summary: The study presents a method for direct preparation of green copolyesters via cascade polycondensation-coupling ring-opening polymerization (PROP), which enables the introduction of multiple functional groups during synthesis, leading to the synthesis of biodegradable polyesters with high molecular weights.
Review
Chemistry, Multidisciplinary
Haidong Li, Heejeong Kim, Feng Xu, Jingjing Han, Qichao Yao, Jingyun Wang, Kanyi Pu, Xiaojun Peng, Juyoung Yoon
Summary: The discovery of hemicyanine dyes as near-infrared fluorescent chromophores has significant implications in detection, bioimaging, and medical therapeutic applications. These dyes possess superior optical properties and structural tailorability, making them promising tools for monitoring biomolecules and diagnosing diseases.
CHEMICAL SOCIETY REVIEWS
(2022)
Article
Polymer Science
An N. Le, Ruiqi Liang, Xiaoyu Ji, Xiaowei Fu, Mingjiang Zhong
Summary: Random copolymerization of norbornene-functionalized macromonomers is a method for synthesizing mixed-graft block copolymers, which can lead to stable phase-separated nanostructures with different side chain compositions. The graft architecture enhances the processability of the material.
JOURNAL OF POLYMER SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Shi-Yi Liu, Xue-Xin Li, Wei-Chao Chen, Kui-Zhan Shao, Xin-Long Wang, Chao Qin, Zhong-Min Su
Summary: The building block strategy is demonstrated to be capable of generating highly reduced polyoxometalates with desirable properties, such as high proton conductivity.
SCIENCE CHINA-CHEMISTRY
(2023)
Article
Construction & Building Technology
Liang Zhang, Jin Wen
Summary: This study explores the application of active learning in data-driven building energy forecasting and develops an effective strategy to address data bias issues. Through virtual and real-world testing, it is demonstrated that building energy forecasting models trained from data generated by the active learning strategy show improved performance.
ENERGY AND BUILDINGS
(2021)
Article
Engineering, Manufacturing
Yan Gui, Zhifang Fei, Shuang Zhao, Zhen Zhang, Huilong Shao, Jun Chen, Kunfeng Li, Hu Du, Zichun Yang
Summary: A novel freeze casting-assisted extrusion printing method is proposed for the fabrication of honeycomb polyimide (PI) aerogels, with properties of the aerogels synchronously regulated by manipulating the ink viscosity and honeycomb porosity. A building block-assembly strategy is developed to fabricate two types of PI aerogel metamaterials for acoustic absorption, exhibiting enhanced overall sound absorption performance.
ADDITIVE MANUFACTURING
(2023)
Article
Biochemistry & Molecular Biology
Sebastian Schmutzler, Daniel Knappe, Andreas Marx, Ralf Hoffmann
Summary: Aldoses and ketoses can glycate proteins to form isomeric Amadori and Heyns products, with d-fructose being more involved in glycoxidation than d-glucose. Despite extensive studies on Amadori products and glucation, the in vivo effects of fructation remain largely unknown. The incorporation of a specific building block in solid-phase peptide synthesis allowed for the identification and characterization of glycated peptides.
Article
Chemistry, Organic
Anastasiya Agafonova, Liya D. Funt, Mikhail S. Novikov, Alexander F. Khlebnikov
Summary: A full atom-economical domino method has been developed for the preparation of alkyl 5-amino-4-cyano-1H-pyrrole-2-carboxylates by transannulation of 5-alkoxyisoxazoles with malononitrile under Fe(ii) catalysis. Alkyl 5-amino-4-cyano-1H-pyrrole-2-carboxylates are excellent building blocks for various annulation reactions, leading to new derivatives of 1H-pyrrolo[1,2-a]imidazole and pyrrolo[2,3-d]pyrimidine. The DFT calculations of mechanistic details of alkyl 5-amino-4-cyano-1H-pyrrole-2-carboxylate formation are presented.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Review
Biochemical Research Methods
Alexis Lossouarn, Pierre-Yves Renard, Cyrille Sabot
Summary: Kinetic target-guided synthesis (KTGS) is a promising tool for discovering biologically active compounds by covalently assembling potent ligands from a pool of reagents. However, the current limited number of biocompatible reactions may not meet the specificities of a wide range of biological targets, thus new reaction types are needed.
BIOCONJUGATE CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Elisabet Viayna, Nicolas Coquelle, Monika Cieslikiewicz-Bouet, Pedro Cisternas, Carolina A. Oliva, Elena Sanchez-Lopez, Miren Ettcheto, Manuela Bartolini, Angela De Simone, Mattia Ricchini, Marisa Rendina, Megane Pons, Omidreza Firuzi, Belen Perez, Luciano Saso, Vincenza Andrisano, Florian Nachon, Xavier Brazzolotto, Maria Luisa Garcia, Antoni Camins, Israel Silman, Ludovic Jean, Nibaldo C. Inestrosa, Jacques-Philippe Colletier, Pierre-Yves Renard, Diego Munoz-Torrero
Summary: By combining the scaffolds of the cholinesterase inhibitor huprine Y and the antioxidant capsaicin, compounds with nanomolar potencies towards AChE and BChE were created, demonstrating potential therapeutic effects for Alzheimer's disease.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Spectroscopy
Sebastien Jenni, Flavien Ponsot, Pierre Baroux, Lucile Collard, Takayuki Ikeno, Kenjiro Hanaoka, Valentin Quesneau, Kevin Renault, Anthony Romieu
Summary: The study explores the potential of DPP derivatives as fluorescence probes for enzyme biosensing, with unique fluorogenic behavior linked to the pyridine unit's N-substitution/charge state. The probes show significant differences in aqueous stability and enzymatic fluorescence activation, outlining their application scope in the field.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Chemistry, Physical
Kevin Renault, Arnaud Chevalier, Jerome Bignon, Denis Jacquemin, Jean-Alexandre Richard, Anthony Romieu
Summary: A novel class of rosamine dyes with a 7-substituted 4-hydroxycoumarin unit as the meso-heteroaryl ring is presented, utilizing the latent C-nucleophilic character of 4-hydroxycoumarin derivatives. Experimental and theoretical photophysical investigations revealed low-lying quenching states with twisted intramolecular charge transfer nature in these unique coumarin-pyronin hybrid structures. Additionally, two fluorophore compounds were used for imaging in paraformaldehyde-fixed A549 cells to study their permeation and localization insights.
Article
Chemistry, Applied
Quentin Ibert, Madeleine Cauwel, Thomas Glachet, Tony Tite, Patricia Le Nahenec-Martel, Jean-Francois Lohier, Pierre-Yves Renard, Xavier Franck, Vincent Reboul, Cyrille Sabot
Summary: Broad scope one-pot diazirine synthesis strategies have been developed using two different oxidants depending on the nature of the starting material. The methods are operationally simple, and tolerant to most functional groups, providing diazirines with yields ranging from 20 to 99%.
ADVANCED SYNTHESIS & CATALYSIS
(2021)
Article
Chemistry, Medicinal
Ophelie Da Silva, Nicolas Probst, Christophe Landry, Anne-Sophie Hanak, Pierre Warnault, Caroline Coisne, Andre-Guilhem Calas, Fabien Gosselet, Charlotte Courageux, Anne-Julie Gastellier, Marilene Trancart, Rachid Baati, Marie-Pierre Dehouck, Ludovic Jean, Florian Nachon, Pierre-Yves Renard, Jose Dias
Summary: Recent events have highlighted the serious threat posed by organophosphorus nerve agents to civilian and military populations. This study proposes the use of glucoconjugated oximes without permanent charge as potential central nervous system reactivators, aiming to overcome the current limitations in therapy. The study evaluates the effectiveness of these compounds, their structural characteristics, and their permeability through the blood-brain barrier.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Alexis Lossouarn, Chloe Puteaux, Laetitia Bailly, Vincent Tognetti, Laurent Joubert, Pierre-Yves Renard, Cyrille Sabot
Summary: This study reports a protein-directed synthesis method for synthesizing carbonic anhydrase inhibitors and discovers unexpected photophysical properties. Fine-tuning of substituents on the coumarin moiety allows for bidirectional photochemical reactions, leading to the discovery of a new photoswitch moiety with fluorescence properties.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Review
Chemistry, Organic
Kevin Renault, Pierre-Yves Renard, Cyrille Sabot
Summary: This review provides an overview of the synthesis of quinoxalin-2(1H)-ones and discusses their fluorescence properties and applications, including chemosensing and biosensing.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Steven Vertueux, Alexandre Haefele, Kathleen Solmont, Philippe Durand, Pierre-Yves Renard
Summary: A series of chemiluminescent cassettes based on adamantyl stabilized 1,2-dioxetanes linked to a fluorophore by a conjugated linker were synthesized in this study. The chemiluminescent decomposition and photoluminescence properties of their respective emissive species were investigated.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Romain Amador, Ali Tahrioui, Magalie Barreau, Olivier Lesouhaitier, Michael Smietana, Guillaume Clave
Summary: Sulfonamides are the oldest class of antibiotics, but their effectiveness has been limited by drug resistance. In this study, we synthesized 18 analogues of sulfa drugs with an N-acylsulfonamide moiety in order to overcome bacterial resistance. These derivatives were efficiently obtained through sulfo-click reactions using readily available thioacid and sulfonyl azide synthons.
RSC MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Maxime Boddaert, Pauline Bianchi, Diana V. Silva-Brenes, Ancuta Musina, Marc Winter, Philippe M. C. Roth, Pierre-Yves Renard, Julien Legros, Jean-Christophe M. Monbaliu
Summary: This study introduces a new, efficient, safe, and sustainable flow protocol using ozone to oxidatively neutralize sulfur-based chemical warfare agent simulants. The combination of computational research and experimental validation has successfully achieved rapid neutralization under flow conditions.
Article
Chemistry, Organic
Romain Amador, Adrien Delpal, Bruno Canard, Jean-Jacques Vasseur, Etienne Decroly, Francoise Debart, Guillaume Clave, Michael Smietana
Summary: N-Acylsulfonamides, possessing unique physico-chemical properties, have attracted increasing interest in medicinal chemistry. This study demonstrates the easy and efficient synthesis of N-acylsulfonamide analogues via the sulfo-click reaction.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Sergui Mansour, Antonin Delaune, Maxime Manneveau, Baptiste Picard, Amelie Claudel, Cecile Vallieres, Lea Sigot, Pierre-Yves Renard, Julien Legros
Summary: This study found that the neutralisation of a simulant of the chemical warfare agent VX can be effectively carried out with lithium ethanolate in a nylon custom printed flow reactor. The formation of EtOLi and the neutralisation can be completed in a single operation. Additionally, the robustness and recyclability of the device were demonstrated.
Article
Chemistry, Multidisciplinary
Adrien T. Normand, E. Daiann Sosa Carrizo, Corentin Magnoux, Esteban Lobato, Helene Cattey, Philippe Richard, Stephane Brandes, Charles H. Devillers, Anthony Romieu, Pierre Le Gendre, Paul Fleurat-Lessard
Summary: The synthesis and characterization of a range of bis(iminophosphoranyl)phosphide (BIPP) group 4 and coinage metals complexes is reported. Various computational tools show that the phosphorus-metal interaction is either electrostatic or dative, with the P-P bonds in both BIPP and TP being normal covalent.
Review
Biochemistry & Molecular Biology
Guillaume Clave, Maeva Reverte, Jean-Jacques Vasseur, Michael Smietana
Summary: In recent years, researchers have made significant modifications to drugs derived from nucleic acids, including altering the internucleoside linkage, which can impact the properties and biological activities of nucleic acids. Ongoing studies continue to explore the potential applications of these modified nucleic acid derivatives.
RSC CHEMICAL BIOLOGY
(2021)
Article
Chemistry, Organic
Faiza Diaba, Gisela Trenchs
Summary: The first violet light-mediated synthesis of gamma- and delta-lactams from N-alkenyl trichloroacetamides is reported in this paper. The reactions are conducted in tetrahydrofuran or 2-methyltetrahydrofuran as the sole solvent without catalysts or additives, under non-anhydrous conditions in an air atmosphere where the solvent serves as the radical initiator.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Feroze Hussain, Sajjad Ahmed, Ashiq Hussain Padder, Qazi Naveed Ahmed
Summary: This study reports a novel and efficient one-pot synthesis method for mixed phosphorotrithioates, which does not require supplementary additives and shows broad applicability.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Hyunjin Oh, Ikyon Kim
Summary: A new 1,2,4-triazole-pyrrolo[1,2-a]pyrazine hybrid system, 6-acylpyrrolo[1,2-a][1,2,4]triazolo[5,1-c]pyrazine, was synthesized using a catalyst-free method. This method involved sequential exposure of pyrrole-2-carbonitrile-derived substrates to DMF-DMA and acyl hydrazide, resulting in the formation of acylated pyrazine and 1,2,4-triazole rings, enabling the installation of various substituents at specific positions on the core skeleton.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Ming Yan, Si-fan Wang, Yong-po Zhang, Jin-zhong Zhao, Zhuo Tang, Guang-xun Li
Summary: Here we developed an efficient photocatalytic approach for the convenient preparation of sulfinamides. The reaction allows for the gram-scale preparation of sulfinamides and the one-pot synthesis of various sulfonyl amides.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Farzaneh Bandehali-Naeini, Zahra Tanbakouchian, Noushin Farajinia-Lehi, Nicolas Mayer, Morteza Shiri, Martin Breugst
Summary: Two tandem catalytic systems were developed for the synthesis of novel 3,4-disubstituted maleimides using the same Ugi adducts. Different maleimide structures can be synthesized using either Pd or Cu catalysis.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Tanya Raghava, Anjan Chattopadhyay, Subhadeep Banerjee, Nivedita Sarkar
Summary: Amine substitution of two ortho fluorine atoms of tetrafluoroterephthalonitrile through SNAr chemistry is easily achievable. But further fluorine substitution is only possible under forcing conditions, yielding valuable fluorophores for bioimaging.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Review
Chemistry, Organic
Anju Chadha, Santosh Kumar Padhi, Selvaraj Stella, Sowmyalakshmi Venkataraman, Thangavelu Saravanan
Summary: Alcohol dehydrogenases are enzymes that use cofactors for oxidation or reduction reactions of alcohols or carbonyl compounds. They are utilized in green chemistry and have applications in the production of pharmaceuticals. Recombinant enzymes have solved the challenge of producing purified enzymes in large quantities. Engineered alcohol dehydrogenases have been used in asymmetric synthesis in industry. Various methods have been established for regenerating expensive cofactors to make the enzymatic process more efficient and economically viable.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)