期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 8, 期 21, 页码 4915-4920出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0ob00208a
关键词
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资金
- Biotechnology and Biological Sciences Research Council
- Wellcome Trust
- European Union
Within cells it is proposed that a major mechanism for the metabolism of formaldehyde is via its reaction with glutathione (GSH) to form S-hydroxymethylglutathione (HMG), which undergoes subsequent oxidation. In addition to HMG and the previously reported (5R,10S)-5-(carboxymethylcarbamoyl)-7-oxo-3-thia-1,6-diazabicyclo[4.4.1]undecane-10-carboxylicacid (BiGF(2)), NMR studies on the reaction of GSH with formaldehyde reveal two previously unassigned monocyclic structures. The results imply that the biologically relevant reactions between aldehydes and peptides/proteins may be more complex than presently perceived.
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