☆ 4.6 Article

Unexpected iron(III) chloride-catalysed dimerisation of 1,1,3-trisubstituted-prop-2-yn-1-ols as an expedient route to highly conjugated indenes

ORGANIC & BIOMOLECULAR CHEMISTRY (2010)

期刊

ORGANIC & BIOMOLECULAR CHEMISTRY

卷 8, 期 17, 页码 4016-4025

出版社

ROYAL SOC CHEMISTRY

DOI: 10.1039/c003522j

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Chemistry, Organic

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Nanyang Technological University [RG55/06]
A*STAR, Singapore [092 1010 053]

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摘要

A method to prepare highly conjugated indenes efficiently by iron(III) chloride-catalysed dimerisation of trisubstituted propargylic alcohols under very mild conditions at room temperature is described. The reactions are rapid and operationally straightforward, giving the indene products in good yields and regioselectivity.

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