期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 8, 期 20, 页码 4625-4636出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0ob00149j
关键词
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资金
- CNRS
- Region Champagne-Ardenne
- Fond Europeen pour le Developpement Regional (FEDER)
- University of Reims
- French Ministry of Education and Research
- Ligue Nationale contre le Cancer, equipe labellisee
A short route, involving a tetramolecular condensation reaction and a Pd/C catalyst-H-2-mediated reductive N-heteroannulation as the key-steps, has been found for the synthesis of some new penta-and heptacyclic indolo- (12), quinolino- (13) and indoloquinolinocarbazole (11) derivatives. HF-DFT (B3LYP) energy profiles and NMR calculations were carried out to help in the understanding of the experimental results. N-Alkylated indoloquinolinocarbazoles (16b, 17a, 17b and 18) were prepared and screened essentially toward some cancer-(G-quadruplex, DNA, topoisomerase I) and CNS-related (kinases) targets. Biological results evidenced 13 as a potent CDK-5 and GSK-3 beta kinases inhibitor, while di- or triaminopropyl-substituted indoloquinolinocarbazoles 17b or 18 targeted rather DNA-duplex or telomeric G-quadruplex structures, respectively.
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