期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 8, 期 5, 页码 1064-1080出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/b915797b
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资金
- GlaxoSmithKline
- EPSRC
- Engineering and Physical Sciences Research Council [EP/E037259/1] Funding Source: researchfish
- EPSRC [EP/E037259/1] Funding Source: UKRI
The development of a Lewis acid-promoted aza-Prins reaction to form piperidines and pyrrolidines is described. Indium trichloride has been found to be a highly successful and mild Lewis acid for promoting this reaction. A thorough mechanistic investigation is described, including the factors that influence the formation of the 5- or 6-membered ring product(s).
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