Biosynthesis of the mitochondrial adenine nucleotide translocase (ATPase) inhibitor bongkrekic acid in Burkholderia gladioli

Biosynthetic studies with (13)C-labelled acetates and methionine revealed that the infamous, food-related toxin bongkrekic acid from Burkholderia gladioli is a polyketide with acetate-derived beta-branches and a carboxylate terminus derived from the methyl group of an acetate.