期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 7, 期 19, 页码 4037-4044出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/b910015f
关键词
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资金
- MIUR (PRIN 2007) Sostanze Naturali ed Analoghi Sintetici con Attivita Antitumorale Rome, Italy
Nine new cyclodepsipeptides, homophymines B-E (2-5) and A1-E1 (1a-5a), were isolated from the polar extracts of the sponge Homophymia sp. The new structures, featuring new polyketide-derived end groups, were determined by interpretation of NMR and MS data. The configurations of the new end groups was secured by the application of J-based configurational analysis. Homophymines displayed very potent antiproliferative activity (IC50 in the nM range) against a panel of human cancer cell lines.
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