期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 7, 期 6, 页码 1203-1210出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/b819607a
关键词
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资金
- UK Biotechnology and Biological Sciences Research Council
- Wellcome Trust International Research Collaboration
- Canadian Institutes of Health Research (CIHR) [MOP 14687]
- BBSRC [BBS/E/J/000C0618] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BBS/E/J/000C0618] Funding Source: researchfish
In connection with studies on lipopolysaccharide biosynthesis in respiratory pathogens we had a need to access potential biosynthetic intermediate sugar nucleotides. Herein we report the chemical synthesis of uridine 5'-diphospho 2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronic acid (UDP-Glc-2,3-diNAcA) (1) from N-acetyl-D-glucosamine in 17 steps and similar to 9% overall yield. This compound has proved invaluable in the elucidation of biosynthetic pathways leading to the formation of 2,3-diacetamido-2,3-dideoxy-D-mannuronic acid-containing polysaccharides.
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