Article
Chemistry, Organic
Peng-Fei Dai, Yi-Ping Wang, Jian-Ping Qu, Yan-Biao Kang
Summary: A synthetically practical transition metal/catalyst/halogen-free dehydrogenative coupling of aldehydes with N-hydroxyimides solely promoted by tert-butyl nitrite under mild conditions was developed. A diverse array of N-hydroxyimide esters can be prepared from either aliphatic or aromatic aldehydes, with benzoyl-substituted aldehydes also being suitable.
Article
Chemistry, Applied
Hongwei Zhu, Junjie Yan, Zhichen Zhang, Junpeng Ren, Yunfeng Zhu, Hui Zhao, Wei Xu, Bing Sun, Chaohe Yang
Summary: This study optimized the synthesis conditions of tert-butyl hydroperoxide using sulfuric acid as a catalyst in a microchannel reactor. The kinetic model of the synthesis was established, and it was found that byproducts were also produced during the reaction.
ORGANIC PROCESS RESEARCH & DEVELOPMENT
(2023)
Article
Environmental Sciences
Nai-Xian Feng, Yu-Xi Feng, Qi-Feng Liang, Xin Chen, Lei Xiang, Hai-Ming Zhao, Bai-Lin Liu, Gang Cao, Yan-Wen Li, Hui Li, Quan-Ying Cai, Ce-Hui Mo, Ming Hung Wong
Summary: A novel bacterium Pseudomonas sp. YJB6 isolated from PAEs-contaminated soil showed strong DBP-degrading activity and could completely degrade DBP within a short period. YJB6 presented a complex and complete degradation pathway for DBP, with high degradation rates and reusability when immobilized.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Thermodynamics
Zhian Huang, Donghong Song, Xiangming Hu, Yinghua Zhang, Yukun Gao, Sainan Quan, Yichao Yin, Yifu Yang, Hongsen Luo, Yucheng Ji
Summary: In this study, a modified antioxidant-type inhibitor (MAT-inhibitor) was developed to address the limitations of current inhibitors used in coal mines. The MAT-inhibitor demonstrated excellent thermal stability, high inhibition performance, and strong water absorption abilities, making it effective in controlling the spontaneous combustion of coal.
Article
Engineering, Chemical
Jordi H. Badia, Carles Fite, Roger Bringue, Fidel Cunill, Javier Tejero
Summary: The kinetics of the simultaneous synthesis of ETBE and BTBE over A35 catalyst in the liquid phase was investigated. Various kinetic modeling approaches were compared, and it was found that empirical power-law modeling provided the best fit, while mechanistic modeling explained the reaction mechanisms.
CHEMICAL ENGINEERING SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Xiaofang Wu, Lei Zhou, Fangshao Li, Jing Xiao
Summary: A novel method utilizing PCl3 has been developed for the conversion of tert-butyl esters into esters and amides in one-pot under air. This method enables the synthesis of bioactive molecule skeletons and gram-scale reactions, and involves the formation of an acid chloride followed by reactions with alcohols or amines to produce the desired products.
JOURNAL OF CHEMICAL RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Zhiqiang Wei, Lixian Wen, Tixian Wen, Kaidi Zhu, Qian Wang, Yanchuan Zhao, Jinbo Hu
Summary: We report a new synthetic protocol for the selective perfluoro-tert-butylation of arenes. By using PFtB phenyl sulfone as a source of PFtB anion, highly regioselective reactions with arynes can yield perfluoro-tert-butylated arenes with high yields. The method is demonstrated by the preparation of sensitive 19F-labeled NMR probes with exceptional resolving ability.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Polymer Science
Chandan Giri, Jen-Yu Chang, Pierre Canisius Mbarushimana, Paul A. Rupar
Summary: In this study, the polymerization of tert-butyl aziridine-1-carboxylate (BocAz) was reported. The introduction of a tert-butyloxycarbonyl (BOC) group effectively activated the anionic-ring-opening polymerization of aziridines, leading to the synthesis of low-molecular-weight poly(BocAz) chains.
Article
Biochemistry & Molecular Biology
Daria Kupczyk, Renata Studzinska, Szymon Baumgart, Rafal Bilski, Tomasz Kosmalski, Renata Kolodziejska, Alina Wozniak
Summary: The research identified 9 novel pseudothiohydantoin derivatives, some of which exhibited high inhibitory activity towards 11 beta-HSD1 or 11 beta-HSD2. These compounds show potential anti-cancer activity and warrant further investigation for their therapeutic effects.
Article
Chemistry, Multidisciplinary
Yaqiqi Jiang, Bao Li, Nana Ma, Sai Shu, Yujie Chen, Shan Yang, Zhibin Huang, Daqing Shi, Yingsheng Zhao
Summary: This study reported a light-promoted C-H trifluoromethylation of arylcarbamates using Langlois reagent under para-selective conditions. Preliminary mechanistic study indicated that the activated organic photocatalyst played a crucial role in achieving para-selective C-H trifluoromethylation. The successful performance of the reaction on a ten-gram scale highlights the synthetic importance of this new protocol.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Palani Natarajan, Onder Metin
Summary: In this study, tert-Butyl nitrite (TBN) was used for the first time as a carbon source to synthesize highly valuable N-tert-butyl amides from nitriles and water under mild conditions.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Applied
Neha Patel, Thambiraja Chokkalingam, Soumyajit Das, Subhrakanti Saha, Karthik Jayaraman, Hemant Bhutani
Summary: A sensitive, reliable, and reproducible method utilizing headspace gas chromatography with flame ionization detection was developed to detect and quantify low levels of tert-butyl nitrite (TBN). The method stabilizes TBN in solution by adding imidazole to the sample diluent and utilizes a high-polarity poly(ethylene glycol) stationary phase for resolution and sensitivity. Validation experiments demonstrated excellent analytical performance in specificity, linearity, precision, and recovery of TBN at trace levels.
ORGANIC PROCESS RESEARCH & DEVELOPMENT
(2021)
Article
Chemistry, Organic
Hong-Xia Zhang, Rui-Li Guo, Xing-Long Zhang, Meng-Yue Wang, Bao-Yin Zhao, Ya-Ru Gao, Qiong Jia, Yong-Qiang Wang
Summary: A new chemistry of azo compounds has been developed, which involves the addition of free radicals generated in situ to various acyl hydrazides. This method provides a novel strategy for the synthesis of valuable acyl hydrazides, with mild reaction conditions, good tolerance of functional groups, and a broad substrate scope.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Jin-Di Xu, Xiao-Bo Su, Cai Wang, Li-Wei Yao, Jing-Hui Liu, Guo-Qin Hu
Summary: An efficient copper-catalyzed addition of arylboronic esters to (Boc)(2)O has been developed, allowing for mild conditions and compatibility with various functional groups. This represents a useful alternative route for synthesizing methyl arylcarboxylates, with a preliminary mechanistic study indicating the involvement of an addition-elimination mechanism.
Article
Chemistry, Organic
Qin Yang, Zhe Wang, Terumasa Kato, Yan Liu, Keiji Maruoka
Summary: Alkyl tert-butyl peroxides are synthesized from their corresponding tert-alkyl precursors and tert-butyl hydroperoxide with the aid of a promoter. These peroxides can be used in a copper-catalyzed radical functionalization, which involves coupling with various partners and exhibits broad substrate compatibility. Mechanistic investigations suggest the involvement of alkyl radical species in the coupling reactions.
Article
Microbiology
Kristina Kovacikova, Marina Gorostiola Gonzalez, Rhian Jones, Juan Reguera, Alba Gigante, Maria-Jesus Perez-Perez, Gerhard Puerstinger, Julia Moesslacher, Thierry Langer, Lak Shin Jeong, Leen Delang, Johan Neyts, Eric J. Snijder, Gerard J. P. van Westen, Martijn J. van Hemert
Summary: This study compared the antiviral efficacy of nsP1 inhibitors and found that CHVB and MADTP series had similar modes of action while differing from the FHNA series. Molecular-docking studies revealed the binding sites and potential actions of different series of inhibitors within the nsP1 structure.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Nanoscience & Nanotechnology
Miryam Criado-Gonzalez, Eva Espinosa-Cano, Luis Rojo, Fouzia Boulmedais, Maria Rosa Aguilar, Rebeca Hernandez
Summary: Supramolecular peptide-based hydrogels with excellent anti-inflammatory properties were developed in this study. The formation of the injectable hybrid hydrogel was triggered by electrostatic interactions between a phosphorylated tripeptide and cationic polymer nanoparticles. The hydrogel exhibited a fibrillary structure and shear thinning behavior, and demonstrated a significant reduction in nitric oxide levels, confirming its potential for the treatment of localized inflammatory pathologies.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Editorial Material
Chemistry, Medicinal
Maria-Jesus Perez-Perez, Juan-Carlos Saiz, Eva-Maria Priego, Miguel A. Martin-Acebes
Summary: The COVID pandemic has shown our vulnerability and the limited treatment options for emerging infectious diseases. Flaviviruses, transmitted by arthropods, pose a global health challenge with no approved drugs for treatment. In this Viewpoint, the advantages and disadvantages of virus-targeting antivirals and host-targeting drugs are analyzed, highlighting their complementary nature.
ACS MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Chemistry, Medicinal
Marta Gargantilla, Jose Lopez-Fernandez, Maria-Jose Camarasa, Leentje Persoons, Dirk Daelemans, Eva-Maria Priego, Maria-Jesus Perez-Perez
Summary: XPO1 is an important target in various human diseases, and its inhibition by compounds like leptomycin B and SINE compounds involves covalent interaction with Cys528. Chalcone derivatives were synthesized and tested for their ability to inhibit XPO1, showing promising results in antiproliferative assays against cancer cells.
Article
Polymer Science
Alejandro Hernandez-Sosa, Rosa Ana Ramirez-Jimenez, Luis Rojo, Fouzia Boulmedais, Maria Rosa Aguilar, Miryam Criado-Gonzalez, Rebeca Hernandez
Summary: This study optimized printable alginate-cellulose ink formulations and successfully fabricated 3D-printed scaffolds with excellent biological functionality. The incorporation of the cell-adhesive peptide Fmoc-FFY improved cell-material adhesion. The scaffolds showed no cytotoxicity to osteosarcoma cells and inhibited their growth, while promoting adhesive interactions with the material.
Article
Polymer Science
Mario Ivan Penas, Ricardo Arpad Perez-Camargo, Rebeca Hernandez, Alejandro J. Mueller
Summary: The impact of plastics on the environment can be reduced by using biobased and/or biodegradable materials as alternatives. One promising alternative is poly (butylene succinate) (PBS) due to its favorable properties. However, the high crystallinity of PBS poses challenges. This contribution provides a comprehensive review of the synthesis routes, modification strategies, and biodegradation behavior of PBS, aiming to position it as a viable and sustainable alternative to traditional plastics.
Article
Chemistry, Medicinal
Marta Gargantilla, Leentje Persoons, Tereza Kauerova, Natalia del Rio, Dirk Daelemans, Eva-Maria Priego, Peter Kollar, Maria-Jesus Perez-Perez
Summary: This study identified new salicylanilide compounds with antiproliferative activity against cancer cells by inhibiting tubulin polymerization and STAT3 phosphorylation, without toxicity towards normal cells.
Review
Biochemistry & Molecular Biology
Tereza Kauerova, Maria-Jesus Perez-Perez, Peter Kollar
Summary: Salicylanilides are pharmacologically active compounds with a wide spectrum of biological effects. Recent studies have shown that halogenated salicylanilides, including the well-studied niclosamide, have potential anticancer properties mediated by various mechanisms such as uncoupling oxidative phosphorylation and inhibiting protein tyrosine kinase. This article provides a comprehensive overview of the proposed mechanisms and structural requirements for the anticancer activity of salicylanilides based on preclinical studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Hadrian Alvarez-Fernandez, Patricia Mingo-Casas, Ana-Belen Blazquez, Flavia Caridi, Juan Carlos Saiz, Maria-Jesus Perez-Perez, Miguel A. Martin-Acebes, Eva-Maria Priego
Summary: Flavivirus, including pathogens such as Zika virus, Dengue virus, and West Nile virus, has no effective antiviral treatment available. Developing host-directed antivirals targeting host factors provides an opportunity for broad-spectrum antivirals. Recent studies have discovered that nSMase2, involved in lipid metabolism, plays a key role in West Nile virus and Zika virus infection. The non-competitive nSMase2 inhibitor DPTIP demonstrated potent antiviral activity against both viruses. Computational studies have identified an allosteric cavity in nSMase2 that can be targeted for the development of new inhibitors with anti-flaviviral activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Nereida Jimenez de Oya, Ana San-Felix, Mireia Casasampere, Ana-Belen Blazquez, Patricia Mingo-Casas, Estela Escribano-Romero, Eva Calvo-Pinilla, Teresa Poderoso, Josefina Casas, Juan-Carlos Saiz, Maria-Jesus Perez-Perez, Miguel A. Martin-Acebes
Summary: Polyphenols like gallic acid and its derivatives have the potential to be used as new therapeutic agents due to their ability to modify lipid metabolism. Through evaluation, two polyphenols, N,N '-(dodecane-1,12-diyl)bis(3,4,5-trihydroxybenzamide) and its 2,3,4-trihydroxybenzamide regioisomer, were found to have selective antiviral activity against West Nile virus, as well as other flaviviruses, with low cytotoxicity. The mechanism of action involves the alteration of sphingolipid metabolism.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Marta Garcia-Zarandieta, Ernesto Quesada, Maria I. Martinez-Jimenez, Cristina V. Newnes, Victor Fernandez-Cabello, Yanira Saez-Alvarez, Ana-Belen Blazquez, Estela Escribano-Romero, Juan-Carlos Saiz, Carmen Del Aguila, Miguel A. Martin-Acebes, Maria-Jesus Perez-Perez, Ruben Agudo
Summary: West Nile virus (WNV) is a mosquito-borne RNA virus that causes encephalitis outbreaks worldwide. There is an urgent need for effective antiviral compounds, particularly those targeting the viral RNA-dependent RNA polymerase (RdRp). We have developed a fluorescence-based method to measure WNV RdRp activity and identified novel inhibitors through high-throughput screening. Rilpivirine showed promising inhibition of WNV RdRp activity and antiviral activity in cell cultures.
ANTIVIRAL RESEARCH
(2023)
Article
Polymer Science
Mario Ivan Penas, Miryam Criado-Gonzalez, Antxon Martinez de Ilarduya, Araceli Flores, Jean-Marie Raquez, Rosica Mincheva, Alejandro J. Mueller, Rebeca Hernandez
Summary: This study presents two strategies to regulate the enzymatic degradation of PBS films. One is to add multilayer coats of polysaccharide alginate and chitosan to the PBS films, and the other is to embed lipase-filled alginate particles in the PBS films. The results show that the number of protective coating layers and the amount of encapsulated enzyme affect the degradation extent of PBS films.
POLYMER DEGRADATION AND STABILITY
(2023)
Article
Polymer Science
Luis Andres Perez, Rebeca Hernandez, Jose Maria Alonso, Raul Perez-Gonzalez, Virginia Saez-Martinez
Summary: Granular polymer hydrogels based on dynamic covalent bonds have gained significant interest for designing injectable biomaterials. These materials exhibit shear-thinning behavior and have the ability to self-heal/recover after extrusion, which can be controlled through interactions between gel microparticles. This study focuses on producing bulk macro-hydrogels using thiolated-hyaluronic acid and disulphide bond formation with oxygen as an oxidant under physiological conditions. The resulting granular hyaluronic hydrogels show potential as stable injectable biomaterials with the ability to form filaments when extruded through a syringe.
Article
Chemistry, Organic
Jose-Maria Orduna, Natalia del Rio, Maria-Jesus Perez-Perez
Summary: Reductive amination of functionalized aldehydes with aniline derivatives of adenine and closely related 7-deazapurines was successfully performed using H-cube technology, avoiding the drawbacks of traditional batch protocols. This method allows for high conversion and easy work-up by evaporation, without the need for acids, making it compatible with acid-sensitive protecting groups.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Maria-Jesus Perez-Perez, Juan-Carlos Saiz, Eva-Maria Priego, Miguel A. Martin-Acebes
Summary: This viewpoint discusses the advantages and disadvantages of virus-targeting antivirals and host-targeting drugs as potential therapies for Flavivirus infections. These two approaches may be complementary, each with its own strengths and weaknesses.
ACS MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Chemistry, Organic
Faiza Diaba, Gisela Trenchs
Summary: The first violet light-mediated synthesis of gamma- and delta-lactams from N-alkenyl trichloroacetamides is reported in this paper. The reactions are conducted in tetrahydrofuran or 2-methyltetrahydrofuran as the sole solvent without catalysts or additives, under non-anhydrous conditions in an air atmosphere where the solvent serves as the radical initiator.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Feroze Hussain, Sajjad Ahmed, Ashiq Hussain Padder, Qazi Naveed Ahmed
Summary: This study reports a novel and efficient one-pot synthesis method for mixed phosphorotrithioates, which does not require supplementary additives and shows broad applicability.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Hyunjin Oh, Ikyon Kim
Summary: A new 1,2,4-triazole-pyrrolo[1,2-a]pyrazine hybrid system, 6-acylpyrrolo[1,2-a][1,2,4]triazolo[5,1-c]pyrazine, was synthesized using a catalyst-free method. This method involved sequential exposure of pyrrole-2-carbonitrile-derived substrates to DMF-DMA and acyl hydrazide, resulting in the formation of acylated pyrazine and 1,2,4-triazole rings, enabling the installation of various substituents at specific positions on the core skeleton.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Ming Yan, Si-fan Wang, Yong-po Zhang, Jin-zhong Zhao, Zhuo Tang, Guang-xun Li
Summary: Here we developed an efficient photocatalytic approach for the convenient preparation of sulfinamides. The reaction allows for the gram-scale preparation of sulfinamides and the one-pot synthesis of various sulfonyl amides.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Farzaneh Bandehali-Naeini, Zahra Tanbakouchian, Noushin Farajinia-Lehi, Nicolas Mayer, Morteza Shiri, Martin Breugst
Summary: Two tandem catalytic systems were developed for the synthesis of novel 3,4-disubstituted maleimides using the same Ugi adducts. Different maleimide structures can be synthesized using either Pd or Cu catalysis.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Tanya Raghava, Anjan Chattopadhyay, Subhadeep Banerjee, Nivedita Sarkar
Summary: Amine substitution of two ortho fluorine atoms of tetrafluoroterephthalonitrile through SNAr chemistry is easily achievable. But further fluorine substitution is only possible under forcing conditions, yielding valuable fluorophores for bioimaging.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Review
Chemistry, Organic
Anju Chadha, Santosh Kumar Padhi, Selvaraj Stella, Sowmyalakshmi Venkataraman, Thangavelu Saravanan
Summary: Alcohol dehydrogenases are enzymes that use cofactors for oxidation or reduction reactions of alcohols or carbonyl compounds. They are utilized in green chemistry and have applications in the production of pharmaceuticals. Recombinant enzymes have solved the challenge of producing purified enzymes in large quantities. Engineered alcohol dehydrogenases have been used in asymmetric synthesis in industry. Various methods have been established for regenerating expensive cofactors to make the enzymatic process more efficient and economically viable.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
