Article
Chemistry, Organic
Sebastiano Mantovani, Angela Pintus, Alessandro Kovtun, Giulio Bertuzzi, Manuela Melucci, Marco Bandini
Summary: A metal-free synthetic approach to functionalized indenes using graphene oxide (GO) is presented in this article. The method involves intramolecular Friedel-Crafts-type allylic alkylations with Morita-Baylis-Hillman alcohols. Experimental and spectroscopic investigations were conducted to understand the reaction mechanism involving a nanostructured carbon material-based C-C bond forming reaction. The results showed that this carbocatalysis approach is a viable option for the synthesis of indenes, with a wide scope and moderate to high yield under mild reaction conditions.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Organic
Shilpa Barik, Sayan Shee, Akkattu T. Biju
Summary: This study presents the N-Heterocyclic carbene (NHC)-catalyzed umpolung of cyclopent-4-ene-1,3-diones, which involves the generation of nucleophilic deoxy-Breslow intermediates. The carbene generated from a commercially available thiazolium salt was found to catalyze the cross-coupling reaction between cyclopent-4-ene-1,3-diones and isatins, resulting in functionalized oxindoles with moderate to good yields and good functional group compatibility. The key deoxy-Breslow intermediates were characterized by X-ray analysis, and detailed mechanistic studies were conducted.
Article
Biochemistry & Molecular Biology
Nompumelelo P. Mathebula, Roger A. Sheldon, Moira L. Bode
Summary: Acylated Morita-Baylis-Hillman (MBH) adducts were synthesized and enzymatic kinetic resolution (EKR) by hydrolysis was carried out using various lipase enzymes. Enantiopure Morita-Baylis-Hillman acetates or butyrates and their hydrolysed MBH adducts were obtained with high enantioselectivity and enantiomeric ratio values. Enantioselective transesterification reactions on MBH adducts were achieved using acyl anhydrides in organic solvents with the presence of CAL-A. This is the first successful report of lipase-catalysed EKR of aromatic MBH adducts by transesterification in an organic medium.
Article
Chemistry, Multidisciplinary
Lei Zhang, Wangzhen Bao, Yuchen Liang, Wenjing Pan, Dongyang Li, Lichun Kong, Zhi-Xiang Wang, Bo Peng
Summary: This study demonstrates the reversal of stereoselectivity in MBH-type [3,3]-rearrangement by using a new pair of rearrangement partners, leading to the synthesis of different types of alpha-aryl alpha,beta-unsaturated carbonyl derivatives. Mechanistic studies provide insights into the reaction pathway and the opposite stereoselectivities observed.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Prashant Shukla, Ambika Asati, Devkumari Patel, Manorama Singh, Vijai K. K. Rai, Ankita Rai
Summary: This study reports on the Morita Baylis-Hillman (MBH) reaction using various aldehydes with acrylonitrile and methyl acrylate as electron-deficient alkenes. A novel catalyst, EDC.HCl, is utilized in the presence of CuI to synthesize the MBH adduct. The synthetic protocol shows excellent product yield (up to 99%), ambient reaction conditions, shorter reaction time, and no side product formation.
Article
Chemistry, Physical
Ricardo Lucas Gomes Pimentel, Rodolfo B. da Silva, Mario Luiz Araujo de Almeida Vasconcellos, Claudio Gabriel Lima-Junior, Fausthon F. da Silva
Summary: This study explores the synthesis and characterization of a mixed-metal copper-manganese iminodiacetate 1D coordination polymer (Cu/Mn-IDA) and its application as a catalyst for the Morita-Baylis-Hillman reaction. The results demonstrate that under optimized conditions, the catalyst can achieve yields of up to 87% for various aldehyde substrates. Additionally, the catalyst exhibits good recyclability.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Organic
Jianning Liao, Jipan Dong, Jiaqing Xu, Wei Wang, Yongjun Wu, Yuxia Hou, Hongchao Guo
Summary: A phosphine-catalyzed [3 + 2] annulation reaction has been developed in this study to synthesize multifunctional isoxazoles with moderate to good yields and diastereoselectivities. The use of a spirocyclic chiral phosphine catalyst resulted in up to 89% ee.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Yue Wang, Manman Song, Er-Qing Li, Zheng Duan
Summary: This study presents a new palladium/phosphine cooperative catalytic system for the synthesis of bicyclo[3.1.0]hexene derivatives, highlighting the crucial roles of both Pd and phosphine in the selective intermolecular activation of Morita-Baylis-Hillman carbonates. This strategy opens up a new avenue for efficient and economical metal/Lewis base dual catalytic systems and provides valuable clues on solving the limitations of selective activation.
ORGANIC CHEMISTRY FRONTIERS
(2021)
Review
Chemistry, Physical
Hugo Santos, Lucas A. Zeoly, Manoel T. Rodrigues Jr, Fabio S. Fernandes, Ralph C. Gomes, Wanda P. Almeida, Fernando Coelho
Summary: Since its discovery in the late 1960s, the Morita-Baylis-Hillman (MBH) reaction has been a powerful carbon-carbon sigma-bond-forming reaction, producing small polyfunctionalized molecules. Advances in functional catalysts and reaction conditions have been made to improve the reaction rate, substrate scope, and enantioselectivity. This review provides an updated summary of the main improvements in catalytic systems for the MBH reaction over the past decade until nowadays, aiming to inspire further investigations and overcome the remaining challenges of this fascinating transformation.
Article
Parasitology
Ana Carolina Santana Vieira, Mariana da Silva Santos, Anderson Brandao Leite, Amanda Evelyn da Silva, Luiz Henrique Agra Cavalcante-Silva, Gabrielle de Souza Augusto Pereira, Sany Delany Gomes Marques, Barbara Viviana de Oliveira Santos, Alysson Wagner Fernandes Duarte, Aline Cavalcante de Queiroz, Kristerson Reinaldo de Luna-Freire, Magna Suzana Alexandre-Moreira
Summary: Leishmaniasis is a neglected disease with limited treatment options and adverse effects. This study evaluated the antileishmanial activity of several derivatives and found that one derivative (1G) showed activity against both promastigote and amastigote forms with low toxicity to macrophages.
PARASITOLOGY RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Lucas Raposo Carvalho, Lucas Gil Venturelli, Thiago Castro Lopes, Eclair Venturini Venturini Filho, Vinicius Goncalves Fontenelle, Guilherme Ferreira de Lima, Leila Lea Yuan Visconte, Eder do Couto Tavares
Summary: Eliminating N-nitrosamines from rubber products is a challenge for the industry, and allyldithiocarbimate salts can be a viable alternative to traditional accelerators, offering better performance.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2023)
Article
Chemistry, Organic
Lin Jiang, Liu-Dong Yu, Pei-Ying Peng, Hong-Li Li, Deng-Bang Jiang, Yi-Dan Wang, Ming-Long Yuan, Ming-Wei Yuan
Summary: A two-step metal-free process has been developed for the stereoselective allylic 1,3-dienylation of Morita-Baylis-Hillman (MBH) carbonates under mild reaction conditions. This transformation involves allylic alkylation with MBH carbonates followed by denitration, resulting in allylic 1,3-dienyl MBH derivatives with exclusive (E)-selectivity.
SYNTHETIC COMMUNICATIONS
(2021)
Article
Chemistry, Physical
Venkatachalam Angamuthu, Chia-Hung Lee, Dar-Fu Tai
Summary: Brucine diol (BD) catalyzed asymmetric Morita-Baylis-Hillman (MBH) reaction is observed for the first time, with Brucine N-oxide (BNO) found to not be an effective chiral catalyst. Faster reaction rates were achieved with unsaturated esters or aromatic aldehydes in the presence of BNO, while the tertiary amine of BD activates vinyl ketone for coupling with aldehyde through an intramolecular carbonylated reaction.
Article
Chemistry, Physical
Yinuo Li, Cuiyu Bao, Zhoutong Sun, Wuyuan Zhang, Bo Yuan
Summary: The oxidation of benzylic alcohols coupled with the Morita-Baylis-Hillman (MBH) reactions in biocatalytic compatible conditions was evaluated. One-pot cascades were described and compared, including a chemoenzymatic cascade with galactose oxidase (GOase M3-5) and 1,4-Diazabicyclo [2.2.2] octane (DABCO), a concurrent dual-enzyme cascade with GOase M3-5 and a computationally designed enzyme MBHase (BH32.14), and a whole cell biotransformation with co-expression modules of the two enzymes. The cascades showed high conversions and yields, with some products having high optical purity.
Article
Chemistry, Multidisciplinary
Felipe C. Braga, Jamal Rafique, Roberto da Silva Gomes, Denis P. de Lima, Adilson Beatriz
Summary: We have developed a protocol for Morita-Baylis-Hillman reactions using TPGS-750 M as an aqueous micellar catalyst. The reaction efficiency is influenced by the solubility and polarity of the substrates in the micellar system, resulting in high yields for various reactive aldehydes. The recyclability of the reaction medium, gram-scale reaction, low loading, room temperature, easy set-up, and purification highlight the user-friendly and practical nature of this method.
SUSTAINABLE CHEMISTRY AND PHARMACY
(2023)
Review
Health Care Sciences & Services
Qingling Wang, Regina L-T Lee, Sharyn Hunter, Sally W-C Chan
Summary: This study found through a systematic review that internet-based telerehabilitation has comparable effectiveness to face-to-face rehabilitation on rehabilitation outcomes among patients after total joint arthroplasty.
JOURNAL OF TELEMEDICINE AND TELECARE
(2023)
Correction
Environmental Sciences
Regina Lai Tong Lee, Shelly Jerrine Lane, Anson Chui Yan Tang, Cynthia Leung, Stephen Wai Hang Kwok, Lobo Hung Tak Louie, Graeme Browne, Sally Wai Chi Chan
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Nursing
Cheng Cheng, Cong-Yan Yang, Kerry Inder, Sally Wai-Chi Chan
Summary: This study examined the psychometric properties of the Chinese version of the Brief Coping Orientation to Problems Experienced (Brief COPE-CN) inventory in patients with MCCs. The results showed that the Brief COPE-CN was acceptable for use with Chinese patients with MCCs, providing valuable insights for developing coping-oriented interventions in this population.
INTERNATIONAL JOURNAL OF NURSING PRACTICE
(2022)
Article
Nursing
Qingling Wang, Sharyn Hunter, Regina Lai-Tong Lee, Xiaofeng Wang, Sally Wai-Chi Chan
Summary: This study aims to understand the specific needs of patients for rehabilitation services delivered via mobile applications after total hip or knee arthroplasty. Findings show that patients require support in rehabilitation self-management, facilitating peer support, contacting healthcare professionals, and emotional well-being. The study provides insights for developing or revising mobile application rehabilitation programs to better support patient rehabilitation.
JOURNAL OF CLINICAL NURSING
(2022)
Article
Health Care Sciences & Services
Zhuo Ma, Sijia Huang, Xiaoqing Wu, Yinying Huang, Sally Wai-Chi Chan, Yilan Lin, Xujuan Zheng, Jiemin Zhu
Summary: This study developed and validated a prognostic app called iCanPredict to predict the overall survival of women with breast cancer in China. The app uses a survival prediction model based on clinical data and shows good predictive ability. It provides important information for guiding treatment decisions for breast cancer.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Review
Nursing
Alex Chan, Sally Wai-chi Chan, Masuma Khanam, Leigh Kinsman
Summary: This integrative review analyzes the perceptions of Chinese people regarding the health effects of dietary salt consumption and the barriers to sustaining a salt-reduced diet for hypertension. The study found that adequate salt-related health education has a positive influence on dietary behavior modifications, the level of educational exposure to the health benefits of salt reduction influences Chinese people's perceptions of the health impact associated with high salt intake, the complexity of salt measurement is a barrier to salt reduction, Chinese food culture poses a challenge to salt reduction, and Chinese migrants may face linguistic and cultural challenges when seeking dietary education and advice for hypertension management.
JOURNAL OF ADVANCED NURSING
(2022)
Review
Nursing
Esmaeel Yaagoob, Sharyn Hunter, Sally Chan
Summary: This integrative review examines the effectiveness of diabetes self-management education (DSME) delivered through social media. The findings suggest that social media DSME can effectively reduce HbA1c levels, increase diabetic knowledge, and improve self-efficacy. However, there is a lack of research on the impact of social media DSME on health-related quality-of-life, anxiety, and depression.
JOURNAL OF CLINICAL NURSING
(2022)
Article
Health Care Sciences & Services
Qishi Zheng, Luming Shi, Lixia Zhu, Nana Jiao, Yap Seng Chong, Sally Wai-Chi Chan, Yiong Huak Chan, Nan Luo, Wenru Wang, Honggu He
Summary: This study evaluated the cost-effectiveness of web-based and home-based postnatal psychoeducational interventions. The web-based intervention program was found to be the most cost-effective, with the least cost and the best improvements in self-efficacy, social support, and psychological well-being.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Nursing
Graeme Drummond Smith, Ken Ho, Allen Lee, Linda Lam, Sally Chan
Summary: This article aims to explore the importance of dementia literacy (DL) in nursing care, including assessment, education, and interventions. Attention should be given to enhance DL in older people, as it is crucial for nursing assessment and care. Greater education on DL is urgently needed globally to improve awareness and understanding of this chronic condition.
JOURNAL OF ADVANCED NURSING
(2023)
Article
Nursing
Ethar Alsharaydeh, Muhammad Alqudah, Regina Lee, Sally Chan
Summary: This study aimed to examine the relationships between challenges, coping, and resilience among immigrant parents caring for children with disabilities. The findings showed that immigrant parents faced challenges such as overwhelming caregiving responsibilities and lack of supportive social networks, but they used various coping strategies and had positive gains from the parental experience. Service providers and social support networks played a facilitative role in immigrant parents' coping.
JOURNAL OF ADVANCED NURSING
(2023)
Article
Nursing
Alex Chan, Leigh Kinsman, Sally Wai-chi Chan
Summary: This study translated the DSRBQ into English and evaluated the psychometric properties of the Chinese and English versions for people of Chinese ethnicity in Australia. The results showed that both the English and Chinese versions had satisfactory psychometric properties for Chinese Australians, indicating acceptable validity and reliability.
Article
Medicine, Research & Experimental
Rick Yiu Cho Kwan, Fowie Ng, Manfred Lai, David Wong, Sally Chan
Summary: This study aims to investigate the impact of using information and communication technology-based tools and intergenerational mentoring strategies on the mental well-being of older adults. The intervention group receives social support through training and support from a digital buddy during the intervention period. The findings of this study will contribute to understanding the effectiveness of this intervention approach on the mental well-being of older adults.
Article
Medicine, Research & Experimental
Rick Yiu Cho Kwan, Fowie Ng, Linda Chiu Wa Lam, Rebecca Choy Yung, Olive Shuk Kan Sin, Sally Chan
Summary: Background: Mental well-being is poor in LTCF residents, and physical disabilities and poor social support are contributing factors. Virtual reality has potential as an effective method to promote mental well-being in LTCF residents, but its effects on those living with physical disabilities are unclear.
Article
Nursing
Alex Chan, Leigh Kinsman, Sally Wai-chi Chan
Summary: The facilitators for reducing salt consumption among Chinese Australians include individual perceptions of health benefits, salt alternatives, digital information, and increased awareness of negative health impacts from a high-salt diet. The identified barriers include lack of apparent physical changes, inadequate salt-related health education, hidden salt in food products, inadequate food literacy, pricing, busy lifestyle, low perceived susceptibility, and individual food taste preference and cooking habits. Peer and family influence can have both positive and negative effects on participants' likelihood of reducing salt consumption.
Article
Psychology, Clinical
Brenda Happell, Shifra Waks, Julia Bocking, Aine Horgan, Fionnuala Manning, Sonya Greaney, John Goodwin, Brett Scholz, Kornelis Jan van der Vaart, Jerry Allon, Elisabeth Hals, Arild Granerud, Rory Doody, Sally Wai-Chi Chan, Mari Lahti, Heikki Ellila, Jarmo Pulli, Annaliina Vatula, Chris Platania-Phung, Graeme Browne, Martha Griffin, Siobhan Russell, Liam MacGabhann, Einar Bjornsson, Pall Biering
Summary: By involving Experts by Experience in teaching, nursing students showed more positive attitudes towards mental health nursing skills and knowledge, including the awareness that mental health issues are everywhere, becoming better practitioners, and gaining better appreciation for mental health nursing.
JOURNAL OF MENTAL HEALTH
(2021)
Article
Chemistry, Organic
Faiza Diaba, Gisela Trenchs
Summary: The first violet light-mediated synthesis of gamma- and delta-lactams from N-alkenyl trichloroacetamides is reported in this paper. The reactions are conducted in tetrahydrofuran or 2-methyltetrahydrofuran as the sole solvent without catalysts or additives, under non-anhydrous conditions in an air atmosphere where the solvent serves as the radical initiator.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Feroze Hussain, Sajjad Ahmed, Ashiq Hussain Padder, Qazi Naveed Ahmed
Summary: This study reports a novel and efficient one-pot synthesis method for mixed phosphorotrithioates, which does not require supplementary additives and shows broad applicability.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Hyunjin Oh, Ikyon Kim
Summary: A new 1,2,4-triazole-pyrrolo[1,2-a]pyrazine hybrid system, 6-acylpyrrolo[1,2-a][1,2,4]triazolo[5,1-c]pyrazine, was synthesized using a catalyst-free method. This method involved sequential exposure of pyrrole-2-carbonitrile-derived substrates to DMF-DMA and acyl hydrazide, resulting in the formation of acylated pyrazine and 1,2,4-triazole rings, enabling the installation of various substituents at specific positions on the core skeleton.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Ming Yan, Si-fan Wang, Yong-po Zhang, Jin-zhong Zhao, Zhuo Tang, Guang-xun Li
Summary: Here we developed an efficient photocatalytic approach for the convenient preparation of sulfinamides. The reaction allows for the gram-scale preparation of sulfinamides and the one-pot synthesis of various sulfonyl amides.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Farzaneh Bandehali-Naeini, Zahra Tanbakouchian, Noushin Farajinia-Lehi, Nicolas Mayer, Morteza Shiri, Martin Breugst
Summary: Two tandem catalytic systems were developed for the synthesis of novel 3,4-disubstituted maleimides using the same Ugi adducts. Different maleimide structures can be synthesized using either Pd or Cu catalysis.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Tanya Raghava, Anjan Chattopadhyay, Subhadeep Banerjee, Nivedita Sarkar
Summary: Amine substitution of two ortho fluorine atoms of tetrafluoroterephthalonitrile through SNAr chemistry is easily achievable. But further fluorine substitution is only possible under forcing conditions, yielding valuable fluorophores for bioimaging.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Review
Chemistry, Organic
Anju Chadha, Santosh Kumar Padhi, Selvaraj Stella, Sowmyalakshmi Venkataraman, Thangavelu Saravanan
Summary: Alcohol dehydrogenases are enzymes that use cofactors for oxidation or reduction reactions of alcohols or carbonyl compounds. They are utilized in green chemistry and have applications in the production of pharmaceuticals. Recombinant enzymes have solved the challenge of producing purified enzymes in large quantities. Engineered alcohol dehydrogenases have been used in asymmetric synthesis in industry. Various methods have been established for regenerating expensive cofactors to make the enzymatic process more efficient and economically viable.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
