期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 6, 期 18, 页码 3264-3269出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/b809569h
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资金
- Ministerio de Ciencia y Tecnologia [CTQ2005-00795/BQU]
- Fondo de Investigacion Sanitaria [PI040993]
- Fundacion Caja Navarra
Novel amine- and ammonium-terminated carbosilane dendrimers of type Gn-[Si{CH2O-(C6H4)-3-NMe2}](lambda) or Gn-[Si{CH2O-(C6H4)-3-NMe(3)(+)l(-)}](x) have been synthesized and characterized Lip to second generation by phenolysis of (chloromethyl)silyl-terminated dendrimers with 3-dimethylarmine phenol and subsequent quaternization with methyl iodide. Quaternized carbosilane dendrimers are stable in protic solvents and can be solubilised in water after the addition of less than 1% of dimethyl sulfoxide. A study of the antimicrobial activity of these cationic dendrimers of first and second generation against both Gram-positive and Gram-negative bacteria is also described. The results obtained demonstrate that the new ammonium-terminated carbosilane dendrimers can be considered as multivalent biocides.
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