Bronsted-acid and Bronsted-base catalyzed Diels-Aider reactions

The enantioselective Diels-Alder reaction is one of the most important reactions for the synthesis of complex molecules. It provides access to chiral six-membered carbocyclic Compounds containing up to four stereogenic centers in a single step. Asymmetric catalysis in the Diels-Alder reaction has mainly been realized using chiral Lewis acids. In this perspective, we describe several cases of chiral Bronsted-acid and Bronsted-base catalyzed Diels-Alder reactions, providing an overview of this rapidly growing field.