Article
Chemistry, Multidisciplinary
Haruki Nagae, Saki Matsushiro, Jun Okuda, Kazushi Mashima
Summary: We discovered that a cationic hetero tetranuclear complex with a calcium and three cobalt ions demonstrated high catalytic activity for the alternating copolymerization of propylene oxide (PO) and carbon dioxide (CO2). The tertiary anilinium salt [PhNMe2H][B(C6F5)(4)] was identified as the best additive to generate the cationic species and maintain polymer selectivity and carbonate linkage, even at 1.0 MPa CO2. Density functional theory calculations revealed that the reaction pathway mediated by the cationic complex is more favorable than that mediated by the neutral complex, with an energy difference of 1.0 kcal mol(-1). Additionally, we found that the exchange of flexible ligands between calcium and cobalt ions is crucial for the smooth proceeding of the alternating copolymerization.
Article
Chemistry, Inorganic & Nuclear
Chen-Yen Tsai, Min-Chia Huang, Mei-Ling Lin, Yu-Chia Su, Chu-Chieh Lin
Summary: A series of Ni complexes supported by SNO Schiff-base derivatives were synthesized in this study. The highest performing catalyst, complex 3, showed excellent efficiency and selectivity in the ring-opening copolymerization of phthalic anhydride (PA) and cyclohexene oxide (CHO).
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Jun Zhu, Yue Zhang, Zeyu Wen, Qiyi Ma, Yongtao Wang, Jia Yao, Haoran Li
Summary: In this study, a highly efficient ruthenium-catalyzed semi-hydrogenation reaction of CO2-derived ureas was reported, resulting in the production of recyclable amines and formamides with high yields (up to 97%). This method shows good substrate applicability and could serve as a sustainable alternative for the hydrogenation of CO2 to formamides in the presence of amines. Furthermore, a new pathway for rapid hydrogenation of urea derivatives even at lower H2 pressure (<5 bar) has been discovered, providing new insights into the reduction functionalization of CO2 to form new C-N bonds.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Review
Polymer Science
Suleiman Gani Musa, Zulkifli Merican Aljunid Merican, Omid Akbarzadeh
Summary: With the escalating issue of global warming, efforts are being made towards achieving a carbon-neutral environment by utilizing non-fossil fuel sources such as solar, nuclear, and biomass energy. Metal-organic frameworks are being explored as potential catalysts for converting CO2 into organic carbonates, given their unique features and ease of synthesis.
Article
Chemistry, Applied
Yuanfeng Wu, Yang Xiao, Hui Yuan, Zongqi Zhang, Shengbin Shi, Ruiping Wei, Lijing Gao, Guomin Xiao
Summary: Imidazolium ionic liquids functionalized UiO-66-NH2 MOFs were synthesized and applied as efficient catalysts for the conversion of CO2 into cyclic carbonates. Various characterization technologies were used to investigate the functionalized UiO-66-NH2, revealing changes in structure and catalytic activity. The catalyst showed promising results in terms of conversion and selectivity, along with good reusability and performance in additional coupling reactions.
MICROPOROUS AND MESOPOROUS MATERIALS
(2021)
Article
Chemistry, Organic
Meng-Cheng Zhang, Dong-Chao Wang, Hai-Ming Guo, Gui-Rong Qu, Hai-Ting Wang
Summary: A new Ni(II)/bisoxazoline-catalyzed asymmetric dearomative [3+2] cycloaddition of substituted purines with donor-acceptor oxiranes was developed. This reaction proceeds via highly chemoselective C-C bond cleavage of the oxiranes, resulting in the formation of chiral purino[3,2-c]oxazole compounds. The reactivity of the substrate is influenced by the electronic effects of the purine ring. The general applicability of this method was demonstrated through gram-scale synthesis, diverse transformations of the product, and the promising biological activities of selected derivatives.
Article
Chemistry, Physical
Zhen He, Cai Xu, Lianjie Li, Anmin Liu, Tingli Ma, Liguo Gao
Summary: Additives play an important role in perovskite solar cells, improving the performance and enhancing the power conversion efficiency of perovskite films. In this study, a novel multifunctional additive, dithiooxamide iodide (DTAI2), was synthesized and found to significantly improve the crystallization and performance of perovskite films.
MATERIALS TODAY ENERGY
(2022)
Article
Chemistry, Multidisciplinary
Jakoba Wacker, Jennifer R. Lynch, Sumanta Banerjee, Peter A. Macdonald, Alan R. Kennedy, Biprajit Sarkar, Robert E. Mulvey
Summary: This study reveals the remarkable structurally complex outcomes of reacting heavy alkali metal (Rb, Cs) amides with benzaldehyde and acetophenone. The reactions give a diversity of eye-catching isolated products, including an enolate with a hexagonal prismatic network, two dienolates with distinct extended ladder motifs, and two beta-imino-alkoxides comprising zig-zag chains of metal-oxygen bonds in infinite cages.
CHEMICAL COMMUNICATIONS
(2023)
Article
Agronomy
Yue Ma, Han Zhou, Yi-Rong Wang, Bao-Qi Zhang, Zhi-Jun Zhang, Deng Peng, Jun-Xia An, Shao-Yong Zhang, Xiong-Fei Luo, Guang-Han Wang, Yan-Yan Ding, Wen-Bin Zhao, Yong-Mei Hu, Ying-Qian Liu
Summary: This study synthesized a series of secondary amine derivatives, among which Compound A26 exhibited high antibacterial activity and strong curative and protective effects against Xanthomonas oryzae. The mechanism of action of Compound A26 involved targeting cell membranes and inhibiting the secretion of extracellular polysaccharides. Secondary amines have efficient and broad-spectrum antibacterial activity and could be considered as a new class of candidate compounds for antibacterial drugs.
PEST MANAGEMENT SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Yi-xin Wang, Jing-hui Zhou, Jun Xiong, Wan-qi Huang, Quan Li, Xue Min, Ming Li
Summary: Two novel metal phosphonate networks based on zoledronic acid were successfully prepared and used as efficient catalysts for the conversion of CO2 gas to cyclic carbonates. The active centers of the catalyst were identified as Lewis acid sites and Bronsted acid sites in the compound structure. Furthermore, the catalyst exhibited good recyclability.
Article
Chemistry, Inorganic & Nuclear
Mu-Jia Li, Yu-Chia Su, Guan-Lin Liu, Bao-Tsan Ko
Summary: This study presents the utilization of hexadentate benzothiazole-based diamine-bisphenolate ligands to synthesize dinickel dicarboxylate complexes for copolymerization of carbon dioxide with epoxides. The dinickel carboxylate complexes exhibit high catalytic performance in the alternating copolymerization of CO2 and cyclohexene oxide, with notable selectivity and molecular weight controllability.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Ninghui Zhang, Chunli Zhang, Xiaoping Hu, Xin Xie, Yuanhong Liu
Summary: An efficient nickel-catalyzed addition of benzyl nitriles to terminal vinyl ketones via C(sp(3))-H functionalization has been developed, providing a novel protocol for the synthesis of α-functionalized benzyl nitriles with structural diversity under mild reaction conditions without the use of a strong base. This work might be potentially useful towards the development of an enantioselective variant using chiral nitrogen ligands.
Article
Chemistry, Multidisciplinary
Gui-Qing Xu, Xue-Ning Ma, Xian-Bin Jia, Ya-Hao Dong, Yu-Qin Jiang, Xin-Juan Li
Summary: It is of significant importance to efficiently synthesize pharmacologically active compounds through CO2 conversion. In this study, polyionic liquids (PILs) with adjustable structures and multiple active sites were synthesized. By using epoxy nucleoside as a solid substrate, cycloaddition and carbonate hydrolysis reactions were carried out under the catalysis of polyionic liquid, CO2, and water. The amphiphilicity of P1, the adjustability of alkalinity, and the regulation of the phase state in the presence of water played crucial roles in achieving high selectivity and yield of the reactions. Moreover, the catalyst could be recycled for 6 times while maintaining high catalytic activity and selectivity. This work provides a solvent-free, metal-free, and recyclable green synthetic pathway for chiral drugs, which will further promote the efficient conversion and utilization of CO2.
Article
Biochemistry & Molecular Biology
Jing Hu, Mengkang Gao, Yang Zhang, Yusui Wang, Zhenrui Qiao, Weiya Zhang, Qiang Wang, Lin Yan, Hai Qian
Summary: In this study, three series of new piperazine urea TRPV1 antagonists were designed, synthesized, and evaluated, among which compound 5ac showed excellent TRPV1 antagonistic activity, good bioavailability, and no hyperthermia side effects. The molecular docking study revealed that compound 5ac interacted well with the amino acid residues on rTRPV1 through hydrophobic interaction, making it an efficient TRPV1 antagonist and a potential candidate for analgesic drug development.
BIOORGANIC CHEMISTRY
(2021)
Article
Chemistry, Applied
Ryota Osuga, Peixuan Fang, Haruka Nishiyama, Koji Takizawa, Noritoshi Yagihashi, Toshiyuki Yokoi, Junko N. Kondo
Summary: Highly active and long-lived Hf-containing SBA-15 catalysts were successfully synthesized using a sol-gel method for the first time, showing higher specific surface area, mesopore volume, and Hf dispersion compared to conventional Hf-supported catalysts, leading to a higher 1,3-butadiene yield.
MICROPOROUS AND MESOPOROUS MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Aaron Gutierrez Collar, Cristina Trujillo, Bruce Lockett-Walters, Brendan Twamley, Stephen J. Connon
CHEMISTRY-A EUROPEAN JOURNAL
(2019)
Article
Chemistry, Multidisciplinary
Aaron Gutierrez Collar, Cristina Trujillo, Stephen J. Connon
CHEMISTRY-A EUROPEAN JOURNAL
(2019)
Article
Chemistry, Physical
Cristina Trujillo, Mili Litvajova, Sarah A. Cronin, Ryan Craig, Stephen J. Connon
Article
Chemistry, Multidisciplinary
Simon N. Smith, Ryan Craig, Stephen J. Connon
CHEMISTRY-A EUROPEAN JOURNAL
(2020)
Article
Chemistry, Multidisciplinary
Simon P. Curran, Brendan J. Fallon, Stephen J. Connon
Article
Biochemistry & Molecular Biology
Claire Fergus, Mashael Al-Qasem, Michelle Cotter, Ciara M. McDonnell, Emiliano Sorrentino, Franciane Chevot, Karsten Hokamp, Mathias O. Senge, John M. Southern, Stephen J. Connon, Vincent P. Kelly
Summary: Base modification can occur throughout a transfer RNA molecule, with a particular emphasis on position 34 of the anticodon loop. Human enzymes can recognize a wide range of artificial derivatives for transfer RNA incorporation, while displaying strict specificity for decoding certain codons. Exploiting the queuosine incorporation pathway shows broad potential for intentionally engineering chemical diversity into transfer RNA anticodons.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Chemistry, Organic
Mili Litvajova, Emiliano Sorrentino, Brendan Twamley, Stephen J. Connon
Summary: This study demonstrates the application of N-protected oxindole derivatives with unprecedented malleability in enantioselective phase-transfer-catalysed alkylations. By optimizing the structure of the catalyst, high levels of enantioselectivity were achieved. It was found that urea-based catalysts outperformed squaramide derivatives, and that installing a chlorine atom in the quinoline moiety of the catalyst improved reaction selectivity.
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Simon N. Smith, Stephen J. Connon
Summary: The ring contraction-lactamisation of anhydrides with trimethylsilylazide in the presence of an amine catalyst has been studied. It is possible to generate 5,- 6- and 8-membered ring lactams from cyclic anhydrides under controlled conditions, with a simple operation procedure. Succinic anhydrides can be used to produce N-carboxyanhydrides for polymer chemistry and as beta-peptide precursors.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Cristina Trujillo, Sarah A. Cronin, Stephen J. Connon
Summary: A complete computational study was conducted to rationalize a new organocatalytic approach for the kinetic resolution of 4-substituted oxazinones, resulting in highly enantioenriched beta-amino acids. The study also investigated the alcoholytic kinetic resolution of a 7-memebered ring analogue for the first time, generating enantioenriched gamma-amino acids.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Ciara M. McDonnell, Magda Ghanim, J. Mike Southern, Vincent P. Kelly, Stephen J. Connon
Summary: This study investigates the impact of modified beta-lysines on the growth rates of eubacterial cells. The results indicate that the observed effects are due to the post translational modification of Elongation Factor P (EFP) catalyzed by PoxA. The promiscuity of PoxA allows for examination of a wide range of exogenous beta-lysines.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Chemistry, Organic
Sarah A. Cronin, Stephen J. Connon
Summary: This study introduces a novel approach to catalytic, alcoholytic kinetic resolution of oxazinones using a stereochemically dense cinchona alkaloid-based catalyst. The catalyst enables highly enantiodiscriminatory ring-opening of oxazinones equipped with electrophilic aryl units, leading to the generation of orthogonally protected beta-amino acids for the first time.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Chemistry, Organic
Eoghan G. Delany, Stephen J. Connon
Summary: The enantioselective intermolecular crossed-benzoin condensation mediated by novel chiral N-heterocyclic carbenes derived from pyroglutamic acid has been investigated. Increasing both the steric requirement and the electron-withdrawing characteristics of the N-aryl ring led to more chemoselective, efficient and enantioselective chemistry. Subsequent protocol optimization involving o-substituted benzaldehyde as one reacting partner allowed a range of crossed-benzoins to be synthesized in moderate-good yields with moderate to excellent enantioselectivity.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Mashael A. Alqasem, Claire Fergus, J. Mike Southern, Stephen J. Connon, Vincent P. Kelly
CHEMICAL COMMUNICATIONS
(2020)
Article
Chemistry, Multidisciplinary
Amy C. Maguire, Vikas Kumar, Stephen J. Connon
CHEMICAL COMMUNICATIONS
(2019)
Article
Chemistry, Multidisciplinary
Bruce Lockett-Walters, Cristina Trujillo, Brendan Twamley, Stephen Connon
CHEMICAL COMMUNICATIONS
(2019)
Article
Chemistry, Organic
Faiza Diaba, Gisela Trenchs
Summary: The first violet light-mediated synthesis of gamma- and delta-lactams from N-alkenyl trichloroacetamides is reported in this paper. The reactions are conducted in tetrahydrofuran or 2-methyltetrahydrofuran as the sole solvent without catalysts or additives, under non-anhydrous conditions in an air atmosphere where the solvent serves as the radical initiator.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Feroze Hussain, Sajjad Ahmed, Ashiq Hussain Padder, Qazi Naveed Ahmed
Summary: This study reports a novel and efficient one-pot synthesis method for mixed phosphorotrithioates, which does not require supplementary additives and shows broad applicability.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Hyunjin Oh, Ikyon Kim
Summary: A new 1,2,4-triazole-pyrrolo[1,2-a]pyrazine hybrid system, 6-acylpyrrolo[1,2-a][1,2,4]triazolo[5,1-c]pyrazine, was synthesized using a catalyst-free method. This method involved sequential exposure of pyrrole-2-carbonitrile-derived substrates to DMF-DMA and acyl hydrazide, resulting in the formation of acylated pyrazine and 1,2,4-triazole rings, enabling the installation of various substituents at specific positions on the core skeleton.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Ming Yan, Si-fan Wang, Yong-po Zhang, Jin-zhong Zhao, Zhuo Tang, Guang-xun Li
Summary: Here we developed an efficient photocatalytic approach for the convenient preparation of sulfinamides. The reaction allows for the gram-scale preparation of sulfinamides and the one-pot synthesis of various sulfonyl amides.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Farzaneh Bandehali-Naeini, Zahra Tanbakouchian, Noushin Farajinia-Lehi, Nicolas Mayer, Morteza Shiri, Martin Breugst
Summary: Two tandem catalytic systems were developed for the synthesis of novel 3,4-disubstituted maleimides using the same Ugi adducts. Different maleimide structures can be synthesized using either Pd or Cu catalysis.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Tanya Raghava, Anjan Chattopadhyay, Subhadeep Banerjee, Nivedita Sarkar
Summary: Amine substitution of two ortho fluorine atoms of tetrafluoroterephthalonitrile through SNAr chemistry is easily achievable. But further fluorine substitution is only possible under forcing conditions, yielding valuable fluorophores for bioimaging.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Review
Chemistry, Organic
Anju Chadha, Santosh Kumar Padhi, Selvaraj Stella, Sowmyalakshmi Venkataraman, Thangavelu Saravanan
Summary: Alcohol dehydrogenases are enzymes that use cofactors for oxidation or reduction reactions of alcohols or carbonyl compounds. They are utilized in green chemistry and have applications in the production of pharmaceuticals. Recombinant enzymes have solved the challenge of producing purified enzymes in large quantities. Engineered alcohol dehydrogenases have been used in asymmetric synthesis in industry. Various methods have been established for regenerating expensive cofactors to make the enzymatic process more efficient and economically viable.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)