期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 6, 期 7, 页码 1278-1287出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/b719713f
关键词
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Several analogues of vanchrobactin, a catechol siderophore isolated from the bacterial fish pathogen Vibrio anguillarum serotype O2 strain RV22, have been synthesized. The biological evaluation of these novel compounds showed that most of them are active as siderophores, as determined by growth promotion assays using the producer strain, as well as V. anguillarum serotype O1, Salmonella enterica, and Erwinia chrysanthemi. These compounds also gave a positive chrome azurol-S ( CAS) test. On the basis of these results, we were able to deduce some structure-activity relationships. Furthermore, we found an analogue with siderophore activity that has appropriate functionality ( an amino group) for use as an antibiotic vector to be employed in a Trojan horse strategy.
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