Article
Cell Biology
Xin Chen, Weiwen Zhu, Rongyao Xu, Xin Shen, Yu Fu, Jie Cheng, Laikui Liu, Hongbing Jiang
Summary: This study revealed that long-term use of bisphosphonates such as Zoledronic Acid (ZA) may lead to Bisphosphonate-related Osteonecrosis of the Jaw (BRONJ) by inhibiting macrophage efferocytosis and promoting osteocytic apoptosis. Additionally, supplementing with geranylgeraniol (GGOH) can restore Rac1 homeostasis and rescue macrophage efferocytosis, potentially providing a new treatment approach for BRONJ.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Guang Yang, Sonal Singh, Caitrin W. McDonough, Jatinder K. Lamba, Issam Hamadeh, L. Shannon Holliday, Danxin Wang, Joseph Katz, Peter A. Lakatos, Bernadett Balla, Janos P. Kosa, Gian Andrea Pelliccioni, Douglas K. Price, Sara L. Van Driest, William D. Figg, Taimour Langaee, Jan S. Moreb, Yan Gong
Summary: The study identified a lead SNP, rs2736308 on chromosome 8, associated with an increased risk of MRONJ in patients with cancer and osteoporosis. This SNP is linked to genes regulating bone mineral density, providing insights into the potential mechanism of MRONJ.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Medicine, General & Internal
Yesel Kim, Jeong-Kui Ku
Summary: This study successfully established a MRONJ rat model on the calvaria, which mimicked the characteristics of MRONJ and can be used for developing treatments for MRONJ.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
George Adrian Ciobanu, Adrian Camen, Mihaela Ionescu, Daniel Vlad, Cristina Maria Munteanu, Mircea Ionut Gheorghita, Cristian Virgil Lungulescu, Ionela Elisabeta Staicu, Elena Claudia Sin, Luminita Chivu, Razvan Mercut, Sanda Mihaela Popescu
Summary: This study aimed to establish the importance of risk factors in the development of MRONJ in cancer patients receiving zoledronic acid therapy. The analysis of 174 cancer patients revealed that treatment duration, chemotherapy, and hypertension were risk factors, while endocrine therapy and obesity were protective factors for MRONJ.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Kota Morishita, Sakiko Soutome, Mitsunobu Otsuru, Saki Hayashida, Maho Murata, Miho Sasaki, Yukinori Takagi, Misa Sumi, Masahiro Umeda
Summary: The study found that a drug holiday of 3 months for medication-related osteonecrosis of the jaw in osteoporosis patients receiving antiresorptive agents does not promote sequestra separation or improve treatment outcomes, and early surgical therapy is recommended.
SCIENTIFIC REPORTS
(2022)
Review
Dentistry, Oral Surgery & Medicine
Farah A. Al-Omari, Shinichiro Kuroshima, Takashi Sawase
Summary: This scoping review examines the medication-related osteonecrosis of the jaw (MRONJ) induced by regenerative therapy (RT) in implant dentistry. The review highlights the limited scientific evidence and knowledge gaps in this field. Further research is needed to establish evidence-based clinical guidelines.
JOURNAL OF DENTISTRY
(2023)
Article
Multidisciplinary Sciences
Kyeong-Mee Park, Namkwon Lee, Jaeyeon Kim, Hyun Sil Kim, Wonse Park
Summary: This study aimed to investigate the preventive effect of teriparatide (TPD) administration on medication-related osteonecrosis of the jaw (MRONJ) before tooth extraction. The results showed that TPD reduced the occurrence of MRONJ in rats treated with zoledronic acid.
SCIENTIFIC REPORTS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Min-Jeong Kwoen, Jung-Hyun Park, Keun-Suh Kim, Jae-Ryun Lee, Jin-Woo Kim, HyeJin Lee, Hyo-Jung Lee
Summary: The presence of periodontal disease significantly increases the risk of medication-related osteonecrosis of the jaw (MRONJ) in patients, even without tooth extraction. Therefore, patients taking bisphosphonates should actively manage and treat periodontal diseases.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
C. G. J. Monteiro, E. M. Vieira, C. Emerick, R. S. Azevedo, V. A. B. Pascoal, N. Homsi, R. X. Lins
Summary: The study aimed to evaluate the preventive effect of ozonated oil on the development of MRONJ-like lesions at tooth extraction sites in rats receiving zoledronic acid treatment. While there was no statistically significant difference in the average area of vital and necrotic bone between the groups, ozonated oil appeared to reduce osteonecrosis development. Further research is needed to confirm these findings.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Zhiqiang Feng, Jingang An, Yang He, Yi Zhang
Summary: This study compared the clinical characteristics of patients with medication-related osteonecrosis of the jaw (MRONJ) and osteoporosis versus malignancy. The results showed differences between the osteoporosis and malignancy groups in terms of incubation periods, cumulative doses of bisphosphonates, and the proportion of patients receiving antiangiogenic agents. However, the two groups had similar surgical treatment outcomes.
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
(2022)
Article
Multidisciplinary Sciences
Seoyeon Jung, Jaeyeon Kim, Jin Hoo Park, Ki-Yeol Kim, Hyung Jun Kim, Wonse Park
Summary: This study aimed to report cases of denosumab-induced MRONJ and investigate the factors affecting its occurrence. The study found that MRONJ can develop as chronic inflammation even without invasive dental treatment. Therefore, preventive dental treatment is necessary before initiating denosumab treatment.
SCIENTIFIC REPORTS
(2022)
Article
Biology
Hiroko Okawa, Takeru Kondo, Akishige Hokugo, Philip Cherian, Jesus J. Campagna, Nicholas A. Lentini, Eric C. Sung, Samantha Chiang, Yi-Ling Lin, Frank H. Ebetino, Varghese John, Shuting Sun, Charles E. McKenna, Ichiro Nishimura
Summary: This study presents a novel method to elucidate the pathological mechanism of BRONJ and demonstrates the potential of HMDP-DNV as an effective therapy. The results show that the intra-oral application of HMDP-DNV can selectively remove legacy N-BP from the jawbone and accelerate wound healing and bone socket healing, while attenuating osteonecrosis development. Single cell RNA sequencing reveals the resolution of chronic inflammation by increasing the expression of anti-inflammatory signature genes. This research suggests that BRONJ pathology is related to N-BP levels in jawbones.
Review
Endocrinology & Metabolism
L. dos Santos Ferreira, L. G. Abreu, C. B. Calderipe, M. D. Martins, L. F. Schuch, A. C. U. Vasconcelos
Summary: The study aimed to integrate data on the use of TPTD for MRONJ cases, finding that TPTD in combination with another therapy, especially antibiotic therapy, can be considered an effective protocol for MRONJ.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Multidisciplinary Sciences
Takuma Watanabe, Keita Asai, Shizuko Fukuhara, Ryuji Uozumi, Kazuhisa Bessho
Summary: This study evaluated the variables associated with treatment outcomes in patients with ARONJ at a single center, finding that surgery and HBO therapy were effective treatment approaches for both stage 2 and 3 ARONJ. Extensive surgery was more effective in healing than conservative surgery for stage 2 ARONJ, while >= 46 sessions of HBO therapy was less associated with healing in the same stage.
Article
Chemistry, Medicinal
Jung Sun Kim, Jin Woo Kim, Jeong Yee, Sun Jong Kim, Jee Eun Chung, Hye Sun Gwak
Summary: This study aimed to investigate the relationship between PPARγ and PPARGC1A polymorphisms and the development of BRONJ in female osteoporosis patients undergoing bisphosphonate treatment. The results showed that PPARGC1A rs2946385 and rs10020457 polymorphisms were significantly associated with BRONJ. Patients with the combined genotypes of GG in both PPARγ rs1151999 and PPARGC1A rs2946385 had a higher risk of BRONJ. Old age (≥70 years) and long duration of bisphosphonate use (≥60 months) also increased the risk of BRONJ.
Article
Dentistry, Oral Surgery & Medicine
Yvonne Yee Lok Lai, Jenny Anne Downs, Kingsley Wong, Sobia Zafar, Laurence James Walsh, Helen Margaret Leonard
Summary: Based on a retrospective observational study of 216 individuals with Rett syndrome, it was found that almost all patients had parafunctional habits, and 66.2% of them exhibited bruxism, with a significant genotypic association. Additionally, there was a higher frequency of snoring among individuals who constantly exhibited nocturnal bruxism.
Article
Dentistry, Oral Surgery & Medicine
J. Tian, J. J. J. Lim, F. K. C. Moh, A. Siddiqi, J. Zachar, S. Zafar
Summary: This study evaluated the knowledge and attitudes of parents and training coaches towards traumatic dental injuries (TDIs) in children. The results showed that parents and coaches had a lack of knowledge, particularly in managing avulsion of permanent teeth. Parents in healthcare occupations were more confident in their knowledge, but there was no significant difference in knowledge levels compared to other professions.
AUSTRALIAN DENTAL JOURNAL
(2022)
Review
Dentistry, Oral Surgery & Medicine
T. Hogerheyde, L. J. Walsh, S. Zafar
Summary: This systematic review examines the current practices of paediatric crown decontamination. The results indicate that autoclaving is commonly used to reduce biological contaminants on crowns, but it can cause microstructural changes and color alterations. The manufacturer guidelines on reprocessing and reuse after biological exposure are ambiguous, raising concerns about potential cross-contamination. Further research is needed to understand the compatibility of paediatric crowns and decontamination practices.
EUROPEAN ARCHIVES OF PAEDIATRIC DENTISTRY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Yvonne Yee Lok Lai, Jenny Anne Downs, Kingsley Wong, Sobia Zafar, Laurence James Walsh, Helen Margaret Leonard
Summary: This study investigates caregivers' perceptions of access to dental care for individuals with Rett syndrome (RTT), finding that dentist-related barriers and caregiver anxiety can both adversely affect dental attendance for those with RTT.
SPECIAL CARE IN DENTISTRY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Seerat Sawhney, Theresa Vu, Fiona Chen, Kingsley Wong, Sobia Zafar, Claudia Patricia Lopez Silva
Summary: This study examined the dental attendance patterns of Australian children with and without disabilities, finding a minimal positive association between disabilities and irregular dental attendance in older children. Factors such as region of residence, parental education, and household income were also related to disability status and dental attendance.
COMMUNITY DENTISTRY AND ORAL EPIDEMIOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Sobia Zafar, Christine Peters
Summary: This study examined the ease of handling different types of flexible splints among dental students and found that wire-free splints with composite bonding were the easiest to place, while glass ionomer cement was the easiest to remove. Most students agreed that the simulated trauma exercise assisted their learning and added value to their dental training.
DENTAL TRAUMATOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Soyeon Jeon, Mark Jeffrey Chong, Gwanghyun Jin, Laurence J. Walsh, Jessica Zachar, Sobia Zafar
Summary: Non-sharps injuries are common in dental school settings. This research analysed the incidences of non-sharps injuries over an 11-year period to identify trends and possible causative factors. The study found that all personnel in dental schools are at similar risk of experiencing non-sharps injuries, with variations in the body site and location of the injuries.
INTERNATIONAL DENTAL JOURNAL
(2022)
Letter
Dentistry, Oral Surgery & Medicine
Yvonne Y. L. Lai, Jenny Downs, Sobia Zafar, Kingsley Wong, Laurence Walsh, Helen Leonard
Article
Dentistry, Oral Surgery & Medicine
Nadeem Hossain, Harmeet Kaur, Divyadarshini Mohanasundaram, Hanny Calache, Sobia Zafar
Summary: This study investigated the confidence and attitudes of final year dentistry students in urban and rural dental programs towards their pediatric dentistry training. The results showed that urban students were more confident in restorative dentistry theory and clinical practice compared to rural students. Additionally, a higher proportion of urban students observed dentists performing treatments on children. Both urban and rural students reported the least confidence in preclinical and clinical skills related to pulp therapies.
INTERNATIONAL JOURNAL OF PAEDIATRIC DENTISTRY
(2023)
Review
Infectious Diseases
Amjad Almuqrin, Inder Preet Kaur, Laurence J. Walsh, Chaminda Jayampath Seneviratne, Sobia Zafar
Summary: Topical cariostatic agents, such as silver diamine fluoride (SDF), are effective in managing dental caries in young children. However, SDF application often leads to unaesthetic tooth discoloration, which can be addressed by using nano-metallic antimicrobials like selenium nanoparticles (SeNPs). SeNPs have shown antimicrobial, antioxidant, and antiviral activities, making them a potential substitute for silver in SDF.
Article
Dentistry, Oral Surgery & Medicine
M. Masood, L. J. Walsh, S. Zafar
Summary: This laboratory-based study investigated the release of ions from metallic piercings when exposed to organic acids (lactic, citric) and inorganic acids (phosphoric, hydrochloric) that could be encountered in the oral cavity. The study found that inorganic acids caused greater release of material per surface area compared to organic acids. This could lead to corrosion and leaching of ions from metallic oral piercings.
AUSTRALIAN DENTAL JOURNAL
(2023)
Review
Dentistry, Oral Surgery & Medicine
Richard Huynh, Christine I. Peters, Sobia Zafar, Ove A. Peters
Summary: This systematic review aimed to assess the stress levels associated with root canal treatment compared to other dental procedures. The review included 23 studies, which found that root canal treatment was more psychologically stressful for patients. However, the stress levels of root canal treatment relative to other procedures, such as extractions, were inconclusive for both patients and providers. It is important for providers to minimize bias towards root canal treatment when discussing treatment options with patients.
EUROPEAN JOURNAL OF ORAL SCIENCES
(2023)
Review
Dentistry, Oral Surgery & Medicine
M. Masood, L. J. Walsh, S. Zafar
Summary: This systematic review examined dental complications associated with metal ion release from oral piercings. The review included 25 studies, and it was found that oral piercings cause damage to both soft and hard oral tissues, particularly gingival recession for lip piercings and tooth chipping for tongue piercings. Therefore, dental professionals should discourage patients from getting oral piercings.
EUROPEAN ARCHIVES OF PAEDIATRIC DENTISTRY
(2023)
Review
Dentistry, Oral Surgery & Medicine
Stefan Danylak, Laurence J. Walsh, Sobia Zafar
Summary: This systematic review explores methods and technologies for measuring ergonomic intervention and prevention in dentistry, highlighting the need for further studies using technology to assess the impacts of training and testing among dental professionals.
JOURNAL OF DENTAL EDUCATION
(2023)