Article
Oncology
Jan Philipp Kuehn, Wendelin Schmid, Sandrina Koerner, Florian Bochen, Silke Wemmert, Hugo Rimbach, Sigrun Smola, Julia Caroline Radosa, Mathias Wagner, Luc G. T. Morris, Victoria Bozzato, Alessandro Bozzato, Bernhard Schick, Maximilian Linxweiler
Summary: The incidence of human papillomavirus (HPV)-related head and neck cancer is on the rise globally, posing challenges for clinical management. It remains unclear which biomarker best reflects HPV-driven carcinogenesis, with P16-IHC performing the best as a single biomarker for prognosis stratification in OPSCC patients among the six potential HPV surrogate biomarkers tested in 153 HNSCC patients.
Editorial Material
Oncology
William M. Lydiatt
Summary: Ho et al. propose revising the pathological staging of oropharyngeal carcinoma in the context of various competing principles of cancer staging.
Review
Virology
Qiang Xu, Ye Chen, Yuan Jin, Zhiyu Wang, Haoru Dong, Andreas M. Kaufmann, Andreas E. Albers, Xu Qian
Summary: The incidence of HR-HPV-driven HNSCC is increasing globally, and it has distinct molecular and clinical characteristics compared to HPV-uninvolved cases. Nanotechnology has played a significant role in personalized cancer therapy, including the development of HPV-E6 or -E7 vaccines based on plasmid, messenger RNA or peptide, the design and utilization of nanoparticles for targeting cancer cells and activating certain immunology pathways, as well as chemotherapy and photothermal treatment. However, breakthroughs in nanomedicine are still awaited.
Article
Dentistry, Oral Surgery & Medicine
Elham Mohebbi, Zainab Alimoradi, Laura S. Rozek, Azadeh Mohebbi, Elahe Jafari
Summary: This study conducted a systematic review and meta-analysis to investigate the risk of head and neck cancer among opium users. The findings showed a significant correlation between opium use and the development of head and neck cancers, particularly lip and oral cavity cancers and laryngeal cancer. This highlights the importance of further research and targeted preventive measures to address this concerning association.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Oncology
Zhi-Qiao Liu, Yan-Fen Feng, Yao Xiao, Xiao-Min Zhang, Ji -Bin Li, Fang-Yun Xie, Yan-Ping Mao
Summary: This study retrospectively analyzed the clinical characteristics, prognostic factors, and optimal treatment strategies of 288 patients with non-metastatic head and neck lymphoepithelioma-like carcinoma (HNLELC). The results showed that 94.8% of patients were positive for EBV and 52.8% had cervical nodal infiltration. Compared to surgery alone, surgery followed by radiotherapy was associated with reduced local and regional relapse-free survival rates. Definitive radiotherapy showed comparable results to surgery followed by radiotherapy in terms of survival outcomes. EBV status was identified as an independent favorable prognostic factor. In conclusion, HNLELC is associated with EBV infection and cervical nodal infiltration. Definitive radiotherapy can be considered as an alternative treatment for patients unfit or unwilling to undergo surgery.
RADIOTHERAPY AND ONCOLOGY
(2023)
Review
Oncology
Mehmet Gunduz, Esra Gunduz, Shunji Tamagawa, Keisuke Enomoto, Muneki Hotomi
Summary: Although progress has been made in understanding cancer stem cells, particularly in oropharyngeal cancer, much remains unknown. These stem cells play roles in tumor invasion, metastasis, drug resistance, and recurrence, but there are still many unanswered questions.
Article
Oncology
Sanjeev Budhathoki, Brenda Diergaarde, Geoffrey Liu, Andrew Olshan, Andrew Ness, Tim Waterboer, Shama Virani, Patricia Basta, Noemi Bender, Nicole Brenner, Tom Dudding, Neil Hayes, Andrew Hope, Shao Hui Huang, Katrina Hueniken, Beatriz Kanterewicz, James D. McKay, Miranda Pring, Steve Thomas, Kathy Wisniewski, Sera Thomas, Yonathan Brhane, Antonio Agudo, Laia Alemany, Areti Lagiou, Luigi Barzan, Cristina Canova, David I. Conway, Claire M. Healy, Ivana Holcatova, Pagona Lagiou, Gary J. Macfarlane, Tatiana V. Macfarlane, Jerry Polesel, Lorenzo Richiardi, Max Robinson, Ariana Znaor, Paul Brennan, Rayjean J. Hung
Summary: To aid early detection of head and neck cancer, a risk prediction model based on demographic and lifestyle factors, HPV serological markers, and genetic markers has been developed. The risk models showed reasonable predictive accuracy for overall head and neck cancer, and substantially improved accuracy for oropharyngeal cancer when including HPV serology. These models may be helpful for identifying high-risk individuals.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Review
Psychology, Multidisciplinary
Anem Iftikhar, Mohammad Islam, Simon Shepherd, Sarah Jones, Ian Ellis
Summary: Lifestyle factors, including alcohol consumption and smoking, play a significant role in the development of head and neck cancers. Promoting healthy lifestyle choices is crucial for improving health and preventing diseases. Stress is known to contribute to the adoption of unhealthy habits such as alcohol and smoking. Understanding the impact of stress on lifestyle choices and exploring the underlying mechanisms can facilitate the development of prevention measures.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Oncology
Reinout H. de Roest, Martijn van der Heijden, Frederik W. R. Wesseling, Emma J. de Ruiter, Martijn W. Heymans, Chris Terhaard, Marije R. Vergeer, Jan Buter, Lot A. Devriese, Jan Paul de Boer, Arash Navran, Ann Hoeben, Conchita Vens, Michiel van den Brekel, Ruud H. Brakenhoff, C. Rene Leemans, Frank Hoebers
Summary: This study collected real-world outcome data from 513 patients with HPV-negative advanced stage HNSCC treated with CRT and found that clinical variables and treatment parameters had a stronger association with overall survival. The association of RT-boost technique with distant metastasis is an important finding that requires further study.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Rex H. Lee, Ritu Roy, Hua Li, Aaron Hechmer, Tian Ran Zhu, Adila Izgutdina, Adam B. Olshen, Daniel E. Johnson, Jennifer R. Grandis
Summary: Currently, there are no clinical strategies utilizing tumor gene expression to inform therapeutic selection for patients with head and neck squamous cell carcinoma (HNSCC). Patient-derived xenografts (PDXs) are translationally relevant preclinical models for human tumors; however, the overall transcriptomic concordance of HNSCC PDXs with primary human HNSCC, especially in HPV+ disease, is understudied. This study characterized 64 HNSCC PDXs at the transcriptomic level and found that PDXs can recapitulate HNSCC molecular subtypes and provide a resource for the discovery of predictive biomarkers for treatment selection in HNSCC.
Article
Oncology
David J. Carpenter, Pranalee Patel, Donna Niedzwiecki, Mairead Dillon, Alexander K. Diaz, Abhishek Kumar, Yvonne M. Mowery, Kerri-Anne Crowell, Rachel D'Anna, Qiuwen Wu, Anna Rodrigues, Amy J. Wisdom, Jennifer A. Dorth, Pretesh R. Patel, Cynthia K. Shortell, David M. Brizel
Summary: The study found that HNC survivors are at high risk for post-RT carotid artery stenosis (CAS), with a dose response effect observed for asymptomatic CAS at doses as low as 10 Gy.
Article
Otorhinolaryngology
Anna C. H. Willemsen, Walmari Pilz, Ann Hoeben, Frank J. P. Hoebers, Annemie M. W. J. Schols, Laura W. J. Baijens
Summary: This study investigates the relationship between cancer cachexia and oropharyngeal dysphagia in patients with head and neck cancer. The findings suggest that cachexia independently predicts the presence of patient-reported dysphagia.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Oncology
Chengwen Gan, Yannan Wang, Yan Tang, Kai Wang, Bincan Sun, Mengxue Wang, Feiya Zhu
Summary: This study analyzed data from 632 head and neck cancer patients and identified diabetes mellitus, primary tumor site (floor of mouth), flap failure, preoperative radiotherapy, and bilateral neck dissection as risk factors for SSI. Machine learning consistently ranked diabetes mellitus, primary tumor site (floor of mouth), and flap failure as the top three among the 26 SSI-related risk factors.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Oncology
Aviane Auguste, Clarisse Joachim, Jacqueline Deloumeaux, Stanie Gaete, Leah Michineau, Cecile Herrmann-Storck, Suzy Duflo, Daniele Luce
Summary: The study found that in the French West Indies, smoking, drinking, high-risk HPV, family history, low BMI, and certain occupations are significantly associated with HNSCC incidence. The majority of HNSCC cases were attributed to smoking and alcohol, with an overall PAF of 89.0%. The impact was greater in men, especially in terms of smoking and drinking.
Review
Biochemistry & Molecular Biology
Arsinoe C. Thomaidou, Panagiota Batsaki, Maria Adamaki, Maria Goulielmaki, Constantin N. Baxevanis, Vassilis Zoumpourlis, Sotirios P. Fortis
Summary: Head and neck cancers comprise a heterogeneous group of tumors with diverse etiologic factors. Certain miRNAs have been identified as potential biomarkers for the diagnosis and prognosis of HNC. Ongoing clinical trials aim to determine the utility of miRNAs in HNC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Vanita Noronha, Aditya Dhanawat, Vijay Maruti Patil, Nandini Menon, Ajay Kumar Singh, Pankaj Chaturvedi, Prathamesh Pai, Devendra Chaukar, Sarbani Ghosh Laskar, Kumar Prabhash
Summary: Neo-adjuvant chemotherapy has shown long term survival benefits in patients with locally advanced oral cavity squamous cell carcinomas.
Article
Oncology
Andrea Costantino, Claudio Sampieri, Gian Marco Pace, Bianca Maria Festa, Luca Cerri, Giorgio Gregory Giordano, Michael Dale, Giuseppe Spriano, Giorgio Peretti, Armando De Virgilio
Summary: This study aimed to predict the necessity of enteral nutrition at 28 days after surgery in patients with head and neck cancers. The results showed that the machine learning models had optimistic accuracy in predicting the need for enteral nutrition, but had moderate sensitivity.
Article
Oncology
Lirui Zhang, Qiaoshi Xu, Zhien Feng
Summary: This study presents a comprehensive clinical, genomic, and transcriptomic analysis of primary ghost cell odontogenic carcinoma (GCOC). The results provide the first comprehensive molecular atlas for primary GCOC, including previously identified CTNNB1 mutation and novel alterations in MAP3K, EP300, and the 22q11.21 region. The transcriptome analysis reveals significant involvement of cytokine-cytokine receptor interaction and the PI3K-Akt signaling pathway. More GCOC cases should be compared to validate these findings for accurate clinical guidance.
Article
Oncology
Emily Capone, Vittoria Perrotti, Ilaria Cela, Rossano Lattanzio, Lucrezia Togni, Corrado Rubini, Vito Carlo Alberto Caponio, Lorenzo Lo Muzio, Martina Colasante, Francesco Giansanti, Rodolfo Ippoliti, Stefano Iacobelli, Michael J. Wick, Nicole Spardy Burr, Gianluca Sala
Summary: This study explores the potential of galectin-3 binding protein (LGALS3BP) as a novel target for antibody-drug conjugate (ADC) therapy in adenoid cystic carcinoma (ACC). The results show that LGALS3BP is highly expressed in ACC tissues and treatment with anti-LGALS3BP ADC leads to durable tumor growth inhibition in animal models.
Article
Oncology
Andrea Costantino, Claudio Sampieri, Piero Giuseppe Meliante, Armando De Virgilio, Se-Heon Kim
Summary: This study compares the outcomes of transoral resections using the da Vinci SP and da Vinci Xi systems for oropharyngeal squamous cell carcinoma (OPSCC). The results indicate that the da Vinci SP system has advantages in terms of reduced docking and console times, as well as improved rates of wide negative resection margins. However, there were no significant differences in complication rates or postoperative functional outcomes between the two systems.
