Review
Medicine, General & Internal
Mayur D. Mody, James W. Rocco, Sue S. Yom, Robert Haddad, Nabil F. Saba
Summary: Head and neck cancer is the seventh most common type of cancer worldwide, with the predominant risk factors being tobacco use, alcohol abuse, and oncogenic viruses. Treatment typically involves a multidisciplinary approach with surgery, radiotherapy, and systemic therapy, and is challenging due to site-specific and histology-specific variations.
Review
Dentistry, Oral Surgery & Medicine
Stijn van Weert, C. Rene Leemans
Summary: This article discusses salvage surgery after failed organ preservation treatment, highlighting the importance of meticulous discussion and planning in a multidisciplinary environment, as well as the need to identify proper prognosticators to ensure an optimal treatment plan for potentially salvageable patients.
Article
Medicine, Research & Experimental
Peter K. M. Ku, Alexander C. Vlantis, Zenon W. C. Yeung, Osan Y. M. Ho, Ryan H. W. Cho, Alex K. F. Lee, Thomas S. C. Hui, Erin P. L. So, Thomas K. T. Law, Victor Abdullah, Andrew van Hasselt, Michael C. F. Tong
Summary: The study found that TSLC surgery can control chronic aspiration while preserving phonation function of the larynx, resulting in better voice and speech quality compared to laryngectomy with a voice prosthesis.
Review
Oncology
Mischa de Ridder, Cornelis P. J. Raaijmakers, Frank A. Pameijer, Remco de Bree, Floris C. J. Reinders, Patricia A. H. Doornaert, Chris H. J. Terhaard, Marielle E. P. Philippens
Summary: MRI-guided radiotherapy has become more routine in the treatment of head and neck cancer. It provides superior anatomical imaging and functional information, while reducing radiation dose to organs at risk.
Article
Oncology
Simon Boeke, David Monnich, Janita E. van Timmeren, Panagiotis Balermpas
Summary: In recent years, the development of new hybrid machines consisting of an MRI and a linear accelerator, MRgRT has revolutionized the field of radiotherapy, especially for HNC patients. However, its application is still in its infancy, and future challenges in terms of new technical, clinical, and logistic aspects need to be addressed.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Issa Mohamad, Taher Abu Hejleh, Monther Qandeel, Maysa Al-Hussaini, Sami Koro, Ayat Taqash, Abdelatif Almousa, Fawzi Abuhijla, Ramiz Abuhijlih, Fatenah Ajlouni, Akram Al-Ibraheem, Dima Abu Laban, Tariq Hussein, Ebrahim Mayta, Wisam Al-Gargaz, Ali Hosni
Summary: HN-MRI demonstrates promising accuracy in predicting tumor invasion of specific laryngeal subsites in patients with laryngeal cancer, and can serve as a valuable tool for pre-operative planning and treatment decision-making.
Article
Oncology
Nam P. Nguyen, Lyndon Kim, Juliette Thariat, Brigitta G. Baumert, Thandeka Mazibuko, Olena Gorobets, Vincent Vinh-Hung, Huan Giap, Tahir Mehmood, Felix Vincent, Alexander Chi, Trinanjan Basu, Gokoulakrichenane Loganadane, Mohammad Mohammadianpanah, Ulf Karlsson, Eromosele Oboite, Joan Oboite, Ahmed Ali, Brandi R. Page
Summary: Immunotherapy with checkpoint inhibitors is well tolerated in older cancer patients, and when combined with modern radiotherapy techniques, it may have a significant benefit for patients with high PD-L1 expression who are not suitable for conventional chemotherapy.
Article
Otorhinolaryngology
Veit Zebralla, Gunnar Wichmann, Markus Pirlich, Carola Hammermueller, Thomas Berger, Klara Zimmermann, Thomas Neumuth, Anja Mehnert-Theuerkauf, Andreas Dietz, Andreas Hinz, Susanne Wiegand
Summary: The study revealed that head and neck cancer patients frequently experience dysphagia, voice problems, and pain, with significant correlations among these symptoms and strong associations with patients' quality of life.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2021)
Article
Oncology
A. Budrukkar, J. L. Guinot, L. Tagliaferri, F. Bussu, A. Garcia-Consuegra, G. Kovacs
Summary: The treatment of head and neck cancers has a significant impact on function and appearance, leading to impaired quality of life. Long-term effects of treatment include difficulty in speech and swallowing, oral incompetence, trismus, dry mouth, dental problems, and bone damage. Brachytherapy, a type of interventional radiotherapy, has shown to improve local control rates and spare organs at risk. Despite its benefits, brachytherapy is underutilized in head and neck cancers, highlighting the need for improvement in its utilization.
Article
Biology
V Zebralla, Susanne Wiegand, Andreas Dietz, Gunnar Wichmann, Thomas Neumuth, Anja Mehnert-Theuerkauf, Andreas Hinz
Summary: Patients with head and neck cancer often experience various severe functional impairments post-treatment, with swallowing difficulties, voice problems, and pain being the most significant. However, over time, patients tend to report fewer problems, although the specific impairments may vary depending on tumor site and treatment regimen. The acquisition of patient-reported outcome data is valuable in improving patient care by exploring and addressing patients' specific problems.
Article
Oncology
Chikatoshi Katada, Manabu Muto, Satoshi Fujii, Tetsuji Yokoyama, Tomonori Yano, Akihito Watanabe, Toshiro Iizuka, Shigetaka Yoshinaga, Ichiro Tateya, Hiroki Mitani, Yuichi Shimizu, Akiko Takahashi, Tomoyuki Kamijo, Noboru Hanaoka, Makoto Abe, Akihiro Shiotani, Koichi Kano, Yukinori Asada, Tamotsu Matsuhashi, Hirohito Umeno, Kenji Okami, Kenichi Goda, Shinichiro Hori, Yoichiro Ono, Shuji Terai, Yasuaki Nagami, Kenichi Takemura, Kenro Kawada, Mizuo Ando, Naoto Shimeno, Akihito Arai, Yasutoshi Sakamoto, Masaaki Ichinoe, Tetsuo Nemoto, Masahiro Fujita, Hidenobu Watanabe, Tadakazu Shimoda, Atsushi Ochiai, Takakuni Kato, Ryuichi Hayashi
Summary: The study examined the safety and efficacy of transoral surgery for superficial head and neck cancer, finding that the procedure was effective with relatively low incidence of adverse events and no treatment-related deaths, indicating it as an effective minimally invasive treatment option.
Article
Otorhinolaryngology
Sarah Almas, Caroline C. Jeffery
Summary: This study aims to characterize late laryngeal dysfunction in long-term head and neck cancer survivors. The majority of patients experienced symptoms such as swallowing dysfunction, voice change, and chronic cough. Video laryngoscopy revealed vocal fold motion abnormalities and mucosal changes in over half of the participants. There was a weak correlation between time since treatment and laryngeal dysfunction, while age, sex, time since treatment, and primary site showed no correlation with the presence or absence of vocal fold motion abnormalities, G-tube status, or tracheostomy-tube status.
LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Yong Teng, Lixia Gao, Antti A. Makitie, Ewa Florek, Agata Czarnywojtek, Nabil F. Saba, Alfio Ferlito
Summary: This review discusses the relationship between ferroptosis and head and neck cancer treatment, including its conceptual framework, mechanism, functional aspects, and implications for tumor therapy. In addition, strategies for improving the efficacy of head and neck cancer treatment through modulation of ferroptosis are summarized.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Peter K. M. Ku, Alexander C. Vlantis, Ryan H. W. Cho, Zenon W. C. Yeung, Osan Y. M. Ho, Thomas S. C. Hui, Victor Abdullah, Andrew van Hasselt, Michael C. F. Tong
Summary: This retrospective study evaluated the long-term swallowing outcomes after surgical treatment for chronic aspiration in patients treated with radiotherapy for head and neck cancer. The results suggest that tubed supraglottic laryngeal closure may be considered as an alternative to laryngectomy for controlling chronic aspiration.
Review
Chemistry, Multidisciplinary
Enrico Antonio Lo Faso, Orazio Gambino, Roberto Pirrone
Summary: The review focuses on delineation methods for head-neck cancer tumors, emphasizing the importance of multimodal images in radiotherapy. A comparison among different approaches highlights the gap in performance between computerized and manual methods.
APPLIED SCIENCES-BASEL
(2021)
Article
Oncology
Xinzhuo Wang, Odile Fargier-Bochaton, Giovanna Dipasquale, Mohamed Laouiti, Melpomeni Kountouri, Olena Gorobets, Nam P. Nguyen, Raymond Miralbell, Vincent Vinh-Hung
Summary: Prone compared with supine deep inspiration breath-hold (DiBH) was associated with a dosimetric gain in 62.1% of left-sided breast cancer patients. High pendulousness and moderately large breast predicted for the gain.
STRAHLENTHERAPIE UND ONKOLOGIE
(2021)
Article
Oncology
Vincent Vinh-Hung, Hendrik Everaert, Olena Gorobets, Hilde Van Parijs, Guy Verfaillie, Marian Vanhoeij, Guy Storme, Christel Fontaine, Jan Lamote, Justine Perrin, Karim Farid, Nam P. Nguyen, Claire Verschraegen, Mark De Ridder
Summary: The study evaluated the prognostic value of preoperative PET in breast cancer compared to LNR, showing PET as a potential prognostic indicator in univariate analysis at a 15-year follow-up. Further investigation is warranted to confirm the trend towards significance in multivariate analysis.
Article
Multidisciplinary Sciences
Odile Fargier-Bochaton, Xinzhuo Wang, Giovanna Dipasquale, Mohamed Laouiti, Melpomeni Kountouri, Olena Gorobets, Nam P. Nguyen, Raymond Miralbell, Vincent Vinh-Hung
Summary: This study examined the dosimetric advantage of using a prone setup for right breast cancer patients and identified breast volume as a significant predictor. The results showed that prone setup reduced lung doses and set a benchmark for achievable dose reduction.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Vincent Vinh-Hung, Hilde Van Parijs, Olena Gorobets, Christel Fontaine, Nam P. Nguyen, Bhumsuk Keam, Dung Minh Nguyen, Mark De Ridder
Summary: In this study, Gini's mean difference (GMD) was used to evaluate the long-term overall survival of women with breast cancer who received neoadjuvant chemotherapy. The results showed that the classification based on the ratio of positive nodes (LNRc) had a higher GMD value, indicating better prognostic value.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Sylvia Verbanck, Hilde Van Parijs, Daniel Schuermans, Vincent Vinh-Hung, Guy Storme, Christel Fontaine, Mark De Ridder, Dirk Verellen, Eef Vanderhelst, Shane Hanon
Summary: Patients with breast cancer undergoing radiation therapy may experience reduced lung capacity, but the long-term effects of different radiation techniques are similar. Most patients with normal lung function at baseline maintain normal lung function status 10 years after treatment.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Oncology
Justine Perrin, Karim Farid, Hilde Van Parijs, Olena Gorobets, Vincent Vinh-Hung, Nam P. Nguyen, Navid Djassemi, Mark De Ridder, Hendrik Everaert
Summary: Preoperative PET has value in predicting long-term survival in breast cancer patients. Positive PET results in specific regions are associated with poor outcomes.
WORLD JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Vincent Vinh-Hung, Olena Gorobets, Gilles Natchagande, Paul Sargos, Ming Yin, Nam P. Nguyen, Claire Verschraegen, Edmund Folefac
Summary: This study compared the effects of low-dose and standard-dose enzalutamide in patients with metastatic prostate cancer and found that patients in the low-dose group had advantages in terms of survival time, longevity, and reduced adverse events.
CLINICAL GENITOURINARY CANCER
(2022)
Article
Oncology
Rita Bentahila, Elie Rassy, Samir Achkar, Florence Sacino, Stefanos Bougas, Alexis Vallard, Vincent Vinh-Hung, Johan Encaoua, Pierre Gustin, Sylvie Mengue, Patricia Pautier, Philippe Morice, Sebastien Gouy, Sophie Espenel, Eric Deutsch, Cyrus Chargari
Summary: This retrospective study reports the experience of a referral network for women with locally advanced cervical cancer (LACC) who require image-guided adaptive brachytherapy (IGABT). The study demonstrates the feasibility of the referral process, but highlights the need for well-defined workflows and appropriate resource allocation to minimize overall treatment time for this advanced technique.
Article
Multidisciplinary Sciences
Murielle Murielle Beaubrun-Renard, Jacqueline Veronique-Baudin, Jonathan Macni, Stephen Ulric-Gervaise, Thierry Almont, Aude Aline-Fardin, Nathalie Grossat, Cristina Furtos, Patrick Escarmant, Vincent Vinh-Hung, Stefanos Bougas, Andre Cabie, Clarisse Joachim
Summary: This study investigated the survival and prognostic factors of women with breast cancer in Martinique, a French overseas territory, from 2008 to 2017. The findings showed overall good prognosis for breast cancer patients and identified several factors associated with increased risk of death, including metastatic disease, triple negative breast cancer, HR+/HER2- status, and age over 75.
Review
Oncology
Vincent Vinh-Hung, Olena Gorobets, Andre Duerinkcx, Suresh Dutta, Eromosele Oboite, Joan Oboite, Ahmed Ali, Thandeka Mazibuko, Ulf Karlsson, Alexander Chi, David Lehrman, Omer Hashim Mohammed, Mohammad Mohammadianpanah, Gokoulakrichenane Loganadane, Natalia Migliore, Maria Vasileiou, Nam P. Nguyen, Huan Giap
Summary: For older patients with locally advanced NSCLC and high PD-L1 expression, using IGRT and RDCPI treatment may be an innovative option that could reduce treatment cost and decrease radiotherapy complications.
TRANSLATIONAL CANCER RESEARCH
(2022)
Article
Oncology
Nam P. Nguyen, Lyndon Kim, Juliette Thariat, Brigitta G. Baumert, Thandeka Mazibuko, Olena Gorobets, Vincent Vinh-Hung, Huan Giap, Tahir Mehmood, Felix Vincent, Alexander Chi, Trinanjan Basu, Gokoulakrichenane Loganadane, Mohammad Mohammadianpanah, Ulf Karlsson, Eromosele Oboite, Joan Oboite, Ahmed Ali, Brandi R. Page
Summary: Immunotherapy with checkpoint inhibitors is well tolerated in older cancer patients, and when combined with modern radiotherapy techniques, it may have a significant benefit for patients with high PD-L1 expression who are not suitable for conventional chemotherapy.
Article
Oncology
Vincent Vinh-Hung, Olena Gorobets, Nele Adriaenssens, Hilde Van Parijs, Guy Storme, Dirk Verellen, Nam P. Nguyen, Nicolas Magne, Mark De Ridder
Summary: This study observed the follow-up of 123 women with stage I-II breast cancer who underwent adjuvant radiotherapy for over 10 years. The study found that there was higher mortality in 2020, with an increase in lung-heart toxicity and a decline in lung-heart function.
Article
Oncology
Nam P. Nguyen, Juliette Thariat, Olena Gorobets, Vincent Vinh-Hung, Lyndon Kim, Sergio Calleja Blanco, Maria Vasileiou, Meritxell Arenas, Thandeka Mazibuko, Huan Giap, Felix Vincent, Alexander Chi, Gokoulakrichenane Loganadane, Mohammad Mohammadianpanah, Agata Rembielak, Ulf Karlsson, Ahmed Ali, Satya Bose, Brandi R. Page
Summary: Cutaneous squamous-cell carcinoma primarily affects older patients, with the head and neck region being the most common site. Surgical resection and radiotherapy are common treatment options, but alternative strategies are needed for older patients who cannot undergo surgery.
Article
Oncology
Nam P. Nguyen, Ahmed Ali, Vincent Vinh-Hung, Olena Gorobets, Alexander Chi, Thandeka Mazibuko, Natalia Migliore, Maria Vasileiou, David Lehrman, Mohammad Mohammadianpanah, Seyed Alireza Javadinia, Gokoulakrichenane Loganadane, Trinanjan Basu, Satya Bose, Ulf Karlsson, Huan Giap
Summary: Oligometastases have a better prognosis, and surgery or SBRT can further improve survival rates. SBRT has advantages in terms of minimal toxicity and induction of PD-L1 formation, which may increase the response to CPI. Thus, a protocol combining SBRT and CPI can be a potential treatment option for older patients with oligometastases, who may not tolerate conventional chemotherapy.
Article
Oncology
Hilde Van Parijs, Elsa Cecilia-Joseph, Olena Gorobets, Guy Storme, Nele Adriaenssens, Benedicte Heyndrickx, Claire Verschraegen, Nam P. Nguyen, Mark De Ridder, Vincent Vinh-Hung
Summary: The study suggests that hypofractionated image-guided radiation therapy (H-IGRT) can be effective in reducing lung-heart toxicity and does not affect disease-free survival in adjuvant therapy for breast cancer.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Vanita Noronha, Aditya Dhanawat, Vijay Maruti Patil, Nandini Menon, Ajay Kumar Singh, Pankaj Chaturvedi, Prathamesh Pai, Devendra Chaukar, Sarbani Ghosh Laskar, Kumar Prabhash
Summary: Neo-adjuvant chemotherapy has shown long term survival benefits in patients with locally advanced oral cavity squamous cell carcinomas.
Article
Oncology
Andrea Costantino, Claudio Sampieri, Gian Marco Pace, Bianca Maria Festa, Luca Cerri, Giorgio Gregory Giordano, Michael Dale, Giuseppe Spriano, Giorgio Peretti, Armando De Virgilio
Summary: This study aimed to predict the necessity of enteral nutrition at 28 days after surgery in patients with head and neck cancers. The results showed that the machine learning models had optimistic accuracy in predicting the need for enteral nutrition, but had moderate sensitivity.
Article
Oncology
Lirui Zhang, Qiaoshi Xu, Zhien Feng
Summary: This study presents a comprehensive clinical, genomic, and transcriptomic analysis of primary ghost cell odontogenic carcinoma (GCOC). The results provide the first comprehensive molecular atlas for primary GCOC, including previously identified CTNNB1 mutation and novel alterations in MAP3K, EP300, and the 22q11.21 region. The transcriptome analysis reveals significant involvement of cytokine-cytokine receptor interaction and the PI3K-Akt signaling pathway. More GCOC cases should be compared to validate these findings for accurate clinical guidance.
Article
Oncology
Emily Capone, Vittoria Perrotti, Ilaria Cela, Rossano Lattanzio, Lucrezia Togni, Corrado Rubini, Vito Carlo Alberto Caponio, Lorenzo Lo Muzio, Martina Colasante, Francesco Giansanti, Rodolfo Ippoliti, Stefano Iacobelli, Michael J. Wick, Nicole Spardy Burr, Gianluca Sala
Summary: This study explores the potential of galectin-3 binding protein (LGALS3BP) as a novel target for antibody-drug conjugate (ADC) therapy in adenoid cystic carcinoma (ACC). The results show that LGALS3BP is highly expressed in ACC tissues and treatment with anti-LGALS3BP ADC leads to durable tumor growth inhibition in animal models.
Article
Oncology
Andrea Costantino, Claudio Sampieri, Piero Giuseppe Meliante, Armando De Virgilio, Se-Heon Kim
Summary: This study compares the outcomes of transoral resections using the da Vinci SP and da Vinci Xi systems for oropharyngeal squamous cell carcinoma (OPSCC). The results indicate that the da Vinci SP system has advantages in terms of reduced docking and console times, as well as improved rates of wide negative resection margins. However, there were no significant differences in complication rates or postoperative functional outcomes between the two systems.
