Article
Medicine, General & Internal
Po-Li Wei, Chin-Sheng Hung, Hsuan-Hsuan Lu, Uyanga Batzorig, Chien-Yu Huang, Yu-Jia Chang
Summary: The study demonstrated that Areca nut extract (ANE) may be a potential new compound for hepatocellular carcinoma (HCC) therapy. ANE treatment resulted in reduced cell viability, increased cell apoptosis, and suppressed tumor progression in xenograft models. Mechanistically, ANE treatment induced ROS-mediated autophagy and lysosome formation.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Food Science & Technology
Shuhan Yi, Luyan Zou, Zongjun Li, Kozue Sakao, Yuanliang Wang, De-Xing Hou
Summary: This study demonstrated that polyphenols from areca nuts exhibit antioxidant activity by inhibiting the MAPK pathway and activating the Nrf2/HO-1 antioxidant pathways, leading to a reduction in ROS generation induced by LPS.
Review
Cell Biology
Liping Wang, Zhangui Tang
Summary: Oral submucous fibrosis (OSF) is a chronic, progressive, scarring, premalignant disease of the oral mucosa, with complex pathogenic factors including areca nut chewing, nutrition, genetics, and immune factors. Immune factors have recently become the focus of medical research on OSF, with attention on how they play a role in the disease's pathogenesis and treatment. OSF is characterized by significant changes in the immune microenvironment, prompting studies on the role of immune cells and substances in the disease.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Review
Dentistry, Oral Surgery & Medicine
Monal Yuwanati, Ramya Ramadoss, Yasusei Kudo, Pratibha Ramani, Mullainathan Senthil Murugan
Summary: This study reveals a low prevalence of oral submucous fibrosis (OSMF) among areca nut chewers (ANC) through a pooled analysis of multiple studies. However, further large-scale studies are recommended to validate this finding.
Article
Biology
Yung-Gu Chang
Summary: Areca nut is a widely used hallucinogenic addicting drug around the world. Its main alkaloid, arecoline, is a toxic compound. The adverse effects of chewing areca nut, such as the risk of cancer and other diseases, as well as its association with low birthweight, are well-known. This article reviews the effects of areca nut and arecoline on embryonic cell differentiation, specifically osteoblasts, myoblasts, and fibroblasts.
Article
Biochemistry & Molecular Biology
Jing-Ru Weng, Balraj Gopula, Po-Chen Chu, Jing-Lan Hu, Chia-Hsien Feng
Summary: This study investigated the anti-tumor activity of a PKM2 inhibitor called MTP in oral squamous cell carcinoma cells. The results showed that MTP inhibited cell growth, induced apoptosis, and modulated the expression of PKM2 and oncogenic biomarkers. In addition, MTP increased reactive oxygen species generation and affected the expression of autophagic genes. These findings suggest that MTP has potential therapeutic use for oral squamous cell carcinoma.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Chemistry, Multidisciplinary
Jiaqi Chen, Ziyu Zhu, Qiaoya Pan, Yang Bai, Mengfei Yu, Yi Zhou
Summary: In this study, a novel nanoparticle Co-Fc@HCQ was successfully synthesized, which achieved targeted therapy for oral squamous cell carcinoma by inhibiting autophagy and enhancing the generation of reactive oxygen species.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Engineering, Environmental
Nurmeen Adil, Hamad Ali, Amna Jabbar Siddiqui, Arslan Ali, Ayaz Ahmed, Hesham R. El-Seedi, Syed Ghulam Musharraf
Summary: Consumption of areca nut products is the leading cause of oral cancers, especially in South Asian countries. This study found that the components of areca nut and its formulations have cytotoxic effects on normal human gingival fibroblasts and can promote the growth of oral squamous cell carcinoma cells. The presence of carcinogens and adulterants in areca nut products poses a hazard to oral health, potentially leading to the development of oral carcinomas.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Review
Dentistry, Oral Surgery & Medicine
Jun Yang, Zi-Yu Wang, Long Huang, Tao-Lin Yu, Shu-Qian Wan, Juan Song, Bing-Liang Zhang, Ming Hu
Summary: The study found a significant association between betel quid and areca nut chewing with poor prognosis in patients with oral cancer, indicating a higher risk of mortality among chewers compared to non-chewers.
Article
Engineering, Environmental
Yuan-Jhe Chang, Rajendra Bose Muthukumaran, Jian-Lian Chen, Hsin-Yi Chang, Yu-Cheng Hung, Chiung-Wen Hu, Mu-Rong Chao
Summary: Combining areca nut and tobacco increases the risk of oral cancer, and saliva is a better diagnostic material. This study used LC-MS/MS to quantify five areca nut-specific alkaloids and three tobacco-specific alkaloids in human saliva. The distribution of ASAs in the oral cavity is affected by the hydrolysis and metabolic activity, and oral mucosa rather than saliva contributes to the metabolism of ASAs.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Review
Biochemistry & Molecular Biology
Pangzhen Zhang, Nathaniel Quan En Chua, Simon Dang, Ashleigh Davis, Kah Wee Chong, Stephen S. Prime, Nicola Cirillo
Summary: Betel quid (BQ), a mixed package chewed by over 600 million people worldwide, is strongly associated with the development of potentially malignant and malignant diseases of the mouth. The composition of BQ varies geographically, and its capacity to induce disease reflects its distinct chemical composition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Shohei Sekiguchi, Akira Yorozu, Fumika Okazaki, Takeshi Niinuma, Akira Takasawa, Eiichiro Yamamoto, Hiroshi Kitajima, Toshiyuki Kubo, Yui Hatanaka, Koyo Nishiyama, Kazuhiro Ogi, Hironari Dehari, Atsushi Kondo, Makoto Kurose, Kazufumi Obata, Akito Kakiuchi, Masahiro Kai, Yoshihiko Hirohashi, Toshihiko Torigoe, Takashi Kojima, Makoto Osanai, Kenichi Takano, Akihiro Miyazaki, Hiromu Suzuki
Summary: This study demonstrates that aortic carboxypeptidase-like protein (ACLP) is highly expressed in cancer-associated fibroblasts (CAFs) in oral squamous cell carcinoma (OSCC) and is activated by cancer cell-induced TGF-β1 signaling pathway. ACLP derived from CAFs enhances migration and infiltration of cancer cells. Furthermore, ACLP is co-expressed with collagen and negatively correlates with tumor infiltration of CD8+ T lymphocytes, suggesting a potential therapeutic target for stromal-targeted therapy and cancer immunotherapy.
Article
Medicine, Research & Experimental
Sachin C. Sarode, Nilesh Kumar Sharma, Gargi Sarode, Devyani Bhatkar
Summary: This paper proposes a new hypothesis for the pathogenesis of oral submucous fibrosis, suggesting that osmotic pressure and hygroscopicity of betel quid amalgamation in the oral cavity are the causative mechanisms. Laboratory experiments and animal studies are proposed to evaluate the hypothesis and potentially improve the management strategies for this disease.
MEDICAL HYPOTHESES
(2022)
Article
Biochemistry & Molecular Biology
Leilei Wang, Chuan Wang, Xuan Li, Zhuoying Tao, Wangyong Zhu, Yuxiong Su, Wing Shan Choi
Summary: This study investigates the synergistic anticancer effects of melatonin and erastin on ROS modulation and subsequent regulated cell death. The combination treatment of melatonin and erastin significantly reduces tumor size and enhances apoptosis and ferroptosis levels in tumor tissues, while decreasing autophagy levels. This combination may serve as a promising alternative strategy for oral cancer treatment.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2023)
Article
Integrative & Complementary Medicine
Chen Chen, Heng Zhang, Siyi Hou, Yue Liu, Lu Ren, Miao Hao, Keyan Chen, Lingkang Li, Xintong Cai, Zisu Deng, Zhuang Liu, Ping Hou
Summary: This study demonstrated that SXSM can promote cell autophagy by activating the AKT/mTOR pathway, reducing ECM deposition induced by AngII, and improving the decreased heart rate in SSS mice.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Meeting Abstract
Oncology
M. H. Wu, W. F. Chiang, T. M. Cheng
EUROPEAN JOURNAL OF CANCER
(2016)
Article
Dentistry, Oral Surgery & Medicine
Chiang-Chin Tsai, Shang-Liang Wu, Shang-Lun Lin, Shun-Yao Ko, Wei-Fan Chiang, Jung-Wu Yang
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2016)
Article
Dentistry, Oral Surgery & Medicine
Shang-Lun Lin, Shang-Liang Wu, Chiang-Chin Tsai, Shun-Yao Ko, Wei-Fan Chiang, Jung-Wu Yang
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2016)
Article
Oncology
Cheng-Chieh Yang, Hsi-Feng Tu, Cheng-Hsien Wu, Hsiu-Chuan Chang, Wei-Fan Chiang, Nai-Chia Shih, Yong-Syu Lee, Shou-Yen Kao, Kuo-Wei Chang
Article
Dentistry, Oral Surgery & Medicine
Lisa Alice Hwang, Chih-Yin Kuo, Jung-Wu Yang, Wei-Fan Chiang
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2017)
Article
Biochemical Research Methods
Yung-Chin Hsiao, Lang-Ming Chi, Kun-Yi Chien, Wei-Fan Chiang, Szu-Fan Chen, Yao-Ning Chuang, Shih-Yu Lin, Chia-Chun Wu, Ya-Ting Chang, Lichieh Julie Chu, Yi-Ting Chen, Shu-Li Chia, Chih-Yen Chien, Kai-Ping Chang, Yu-Sun Chang, Jau-Song Yu
MOLECULAR & CELLULAR PROTEOMICS
(2017)
Article
Biochemistry & Molecular Biology
W-F Chiang, T-M Cheng, C-C Chang, S-H Pan, C. A. Changou, T-H Chang, K-H Lee, S-Y Wu, Y-F Chen, K-H Chuang, D-B Shieh, Y-L Chen, C-C Tu, W-L Tsui, M-H Wu
Article
Multidisciplinary Sciences
Jing-Wen Shih, Wei-Fan Chiang, Alexander T. H. Wu, Ming-Heng Wu, Ling-Yu Wang, Yen-Ling Yu, Yu-Wen Hung, Wen-Chang Wang, Cheng-Ying Chu, Chiu-Lien Hung, Chun A. Changou, Yun Yen, Hsing-Jien Kung
NATURE COMMUNICATIONS
(2017)
Article
Multidisciplinary Sciences
Ting-Wen Chen, Chi-Ching Lee, Hsuan Liu, Chi-Sheng Wu, Curtis R. Pickering, Po-Jung Huang, Jing Wang, Ian Yi-Feng Chang, Yuan-Ming Yeh, Chih-De Chen, Hsin-Pai Li, Ji-Dung Luo, Bertrand Chin-Ming Tan, Timothy En Haw Chan, Chuen Hsueh, Lichieh Julie Chu, Yi-Ting Chen, Bing Zhang, Chia-Yu Yang, Chih-Ching Wu, Chia-Wei Hsu, Lai-Chu See, Petrus Tang, Jau-Song Yu, Wei-Chao Liao, Wei-Fan Chiang, Henry Rodriguez, Jeffrey N. Myers, Kai-Ping Chang, Yu-Sun Chang
NATURE COMMUNICATIONS
(2017)
Article
Dentistry, Oral Surgery & Medicine
Shang-Lun Lin, Shang-Liang Wu, Shun-Yao Ko, Ching-Yu Yen, Wei-Fan Chiang, Jung-Wu Yang
Article
Otorhinolaryngology
Ming-Heng Wu, Ji-Dung Luo, Wen-Chang Wang, Tzu-Hao Chang, Wei-Lun Hwang, Kuen-Haur Lee, Shyun-Yeu Liu, Jung-Wu Yang, Chang-Ta Chiou, Chi-Hua Chang, Wei-Fan Chiang
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2018)
Article
Medicine, General & Internal
Shang-Lun Lin, Chiang-Chin Tsai, Shang-Liang Wu, Shun-Yao Ko, Wei-Fan Chiang, Jung Wu Yang
Article
Biochemical Research Methods
Yung-Chin Hsiao, Lichieh Julie Chu, Yi-Ting Chen, Lang-Ming Chi, Kun-Yi Chien, Wei-Fan Chiang, Ya-Ting Chang, Szu-Fan Chen, Wei-Shun Wang, Yao-Ning Chuang, Shih-Yu Lin, Chih-Yen Chien, Kai-Ping Chang, Yu-Sun Chang, Jau-Song Yu
PROTEOMICS CLINICAL APPLICATIONS
(2018)
Article
Medicine, Research & Experimental
Yi-Hsuan Lai, Hsuan Liu, Wei-Fan Chiang, Ting-Wen Chen, Lichieh Julie Chu, Jau-Song Yu, Shu-Jen Chen, Hua-Chien Chen, Bertrand Chin-Ming Tan
Meeting Abstract
Oncology
Ming-Heng Wu, Wei-Fan Chiang, Tsai-Mu Cheng, Wan-Lin Tsui
Article
Oncology
Vanita Noronha, Aditya Dhanawat, Vijay Maruti Patil, Nandini Menon, Ajay Kumar Singh, Pankaj Chaturvedi, Prathamesh Pai, Devendra Chaukar, Sarbani Ghosh Laskar, Kumar Prabhash
Summary: Neo-adjuvant chemotherapy has shown long term survival benefits in patients with locally advanced oral cavity squamous cell carcinomas.
Article
Oncology
Andrea Costantino, Claudio Sampieri, Gian Marco Pace, Bianca Maria Festa, Luca Cerri, Giorgio Gregory Giordano, Michael Dale, Giuseppe Spriano, Giorgio Peretti, Armando De Virgilio
Summary: This study aimed to predict the necessity of enteral nutrition at 28 days after surgery in patients with head and neck cancers. The results showed that the machine learning models had optimistic accuracy in predicting the need for enteral nutrition, but had moderate sensitivity.
Article
Oncology
Lirui Zhang, Qiaoshi Xu, Zhien Feng
Summary: This study presents a comprehensive clinical, genomic, and transcriptomic analysis of primary ghost cell odontogenic carcinoma (GCOC). The results provide the first comprehensive molecular atlas for primary GCOC, including previously identified CTNNB1 mutation and novel alterations in MAP3K, EP300, and the 22q11.21 region. The transcriptome analysis reveals significant involvement of cytokine-cytokine receptor interaction and the PI3K-Akt signaling pathway. More GCOC cases should be compared to validate these findings for accurate clinical guidance.
Article
Oncology
Emily Capone, Vittoria Perrotti, Ilaria Cela, Rossano Lattanzio, Lucrezia Togni, Corrado Rubini, Vito Carlo Alberto Caponio, Lorenzo Lo Muzio, Martina Colasante, Francesco Giansanti, Rodolfo Ippoliti, Stefano Iacobelli, Michael J. Wick, Nicole Spardy Burr, Gianluca Sala
Summary: This study explores the potential of galectin-3 binding protein (LGALS3BP) as a novel target for antibody-drug conjugate (ADC) therapy in adenoid cystic carcinoma (ACC). The results show that LGALS3BP is highly expressed in ACC tissues and treatment with anti-LGALS3BP ADC leads to durable tumor growth inhibition in animal models.
Article
Oncology
Andrea Costantino, Claudio Sampieri, Piero Giuseppe Meliante, Armando De Virgilio, Se-Heon Kim
Summary: This study compares the outcomes of transoral resections using the da Vinci SP and da Vinci Xi systems for oropharyngeal squamous cell carcinoma (OPSCC). The results indicate that the da Vinci SP system has advantages in terms of reduced docking and console times, as well as improved rates of wide negative resection margins. However, there were no significant differences in complication rates or postoperative functional outcomes between the two systems.