期刊
ORAL ONCOLOGY
卷 45, 期 10, 页码 920-925出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.oraloncology.2009.04.007
关键词
Enzyme-linked immunosorbent assay; Lymph node metastasis; Matrix metalloproteinase-9; Oral cancer; Serum; Survival; Vascular endothelial growth factor
资金
- National Science Council [NS-96-2628-B-010-033-MY3, NSC-96-2314-B-195-018-MY3]
- Taipei Mackay Hospital, Taiwan [9717]
Matrix metalloproteinase (MMP)-9 and vascular endothelial growth factor (VEGF) are two proteins involved in angiogenesis. In the present study we investigated the association of pretreatment MMP-9 and VEGF serum levels with clinicopathological parameters and outcome in patients with oral squamous cell carcinoma. Pretreatment serum levels of MMP-9 and VEGF were analyzed in 161 patients with use of enzyme-linked immunoassays. Patients with a VEGF serum level higher than the mean serum level (497.04 pg/mL) had a significantly shorter overall survival than those with a serum level lower than median (p < 0.0001). Patients with MMP-9 serum levels higher than median (226.7 ng/mL) had significantly shorter overall survival than those with levels lower than median (p = 0.01). In addition to cervical lymph node metastasis and tumor stage, pretreatment serum levels of MMP-9 and VEGF were identified as independent prognostic factors in multivariate Cox regression analysis. We conclude pretreatment serum levels of MMP-9 and VEGF are new powerful prognostic markers in patients with oral squamous cell carcinoma. Crown Copyright (C) 2009 Published by Elsevier Ltd. All rights reserved.
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