Article
Cell Biology
Satsuki Nakano, Yoshihide Okumura, Takayuki Murase, Toshitaka Nagao, Kimihide Kusafuka, Makoto Urano, Hidetaka Yamamoto, Satoshi Kano, Kiyoaki Tsukahara, Kenji Okami, Daisuke Kawakita, Toru Nagao, Nobuhiro Hanai, Hiroshi Iwai, Ryo Kawata, Yuichiro Tada, Ken-Ichi Nibu, Hiroshi Inagaki
Summary: The study investigated the histological diversity of salivary mucoepidermoid carcinoma (MEC), its clinicopathological features, and its associations with CRTC1/3-MAML2 fusions. The research found that MEC exhibits various histological variants and that the CRTC1/3-MAML2 fusion may be associated with the clinicopathological features of MEC.
Article
Cell Biology
Justin A. Bishop, Lester D. R. Thompson, Bradford Siegele, Jeffrey Gagan, Mena Mansour, Rebecca D. Chernock, Lisa M. Rooper
Summary: Mucoepidermoid carcinoma (MEC) is traditionally defined by a mix of squamoid, intermediate, and mucous cells, but recent studies have found unique cases lacking immunoreactivity for squamous markers despite MAML2 fusions. This study characterizes these tumors and identifies the importance of MAML2 analysis in diagnosing MEC without squamoid cells.
Article
Medicine, Research & Experimental
Zirong Chen, Wei Ni, Jian-Liang Li, Shuibin Lin, Xin Zhou, Yuping Sun, Jennifer W. Li, Marino E. Leon, Maria D. Hurtado, Sergei Zolotukhin, Chen Liu, Jianrong Lu, James D. Griffin, Frederic J. Kaye, Lizi Wu
Summary: This study provides direct evidence that CRTC1-MAML2 is a key driver for MEC development and maintenance. Combination therapy targeting aberrant p16-CDK4/6-RB signaling and CRTC1-MAML2 fusion-activated AREG/EGFR signaling with the respective CDK4/6 inhibitor Palbociclib and EGFR inhibitor Erlotinib produced enhanced antitumor responses in vitro and in vivo, offering a potential viable strategy for patients with MEC.
Article
Virology
Wenjin Gu, Apurva Bhangale, Molly E. Heft Neal, Josh D. Smith, Collin Brummel, Jonathan B. McHugh, Matthew E. Spector, Ryan E. Mills, J. Chad Brenner
Summary: HPV is a rare driver in mucoepidermoid carcinoma, but it may have a substantial role in cases that harbor the virus.
Article
Pathology
Bokyung Ahn, Seung-Ho Choi, Doeun Kim, Deokhoon Kim, Kyung-Ja Cho
Summary: We report a series of trabecular variants of mucopidermoid carcinomas (MECs) with unique histological and molecular features. These variants have characteristics different from known disease entities and may result in misdiagnosis. The tumors primarily occur in middle-aged females and are commonly located in the parotid gland and oral cavity. No recurrences or deaths were observed during the follow-up period.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2023)
Article
Otorhinolaryngology
Stijn van Weert, Birgit Lissenberg-Witte, Elisabeth Bloemena, C. Rene Leemans
Summary: Mucoepidermoid carcinoma (MEC) of the head and neck generally has a favorable outcome, except for high-grade MEC. Perineural invasion and nodal involvement are not rare, and the overall recurrence rate is less than 20%. The presence of the CRTC1/3 MAML 2 fusion gene does not provide a survival benefit.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2021)
Article
Otorhinolaryngology
Stephen A. Chan, Kathryn M. Van Abel, Jean E. Lewis, David M. Routman, Joaquin J. Garcia, Emily E. Karp, Daniel L. Price, Jeffrey R. Janus, Jan L. Kasperbauer, Eric J. Moore
Summary: Surgical resection and adjuvant radiation therapy for high-grade or advanced-stage parotid gland mucoepidermoid carcinoma (MEC) result in excellent survival rates, regardless of clinical stage or pathological grade.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Pathology
Andre Fehr, Sarah Werenicz, Pietro Trocchi, Markus Falk, Reinhard E. Friedrich, Angelika Stammler, Andreas Stang, Florian Oesterling, Laura Khil, Goran Stenman, Werner Boecker, Katharina Tiemann, Thomas Loening
Summary: Mucoepidermoid carcinoma (MEC) is the most common carcinoma of the salivary glands. Two large patient cohorts were studied to analyze clinical, histological, and molecular predictors of survival in MECs. The AFIP and Brandwein grading systems were found to be useful in estimating prognosis for G3-MECs, with G3 tumors having worse survival outcomes. Fusion-negative MECs showed a poorer 5-year progression-free survival, and CRTC1/3-MAML2 testing is recommended for more precise prognosis assessment and avoiding overtreatment.
Article
Dermatology
Eleanor Russell-Goldman, John Hanna
Summary: Hidradenoma is a benign skin tumor with diverse cell types, often resembling mucoepidermoid carcinoma. This study found that the majority of hidradenomas have MAML2 translocations, providing insights into its molecular characteristics and aiding in its differentiation from other tumors.
AMERICAN JOURNAL OF DERMATOPATHOLOGY
(2022)
Article
Medical Laboratory Technology
Chunye Zhang, Ting Gu, Yuhua Hu, Jingjing Sun, Ronghui Xia, Zhen Tian, Lizhen Wang, Jiang Li
Summary: The study found that Warthin-like MEC and LAD share overlapping clinicopathologic features, and accurate differentiation requires careful histologic evaluation and detection of MAML2 rearrangement.
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2021)
Article
Pathology
Bin Xu, Bayan Alzumaili, Karina C. Furlan, German H. Martinez, Marc Cohen, Ian Ganly, Ronald A. Ghossein, Nora Katabi
Summary: This study evaluated the pathological factors and grading schemes in mucoepidermoid carcinoma, and found that high-grade histology was associated with an increased risk of nodal metastasis and decreased survival rate.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2023)
Article
Oncology
Kazuma Noguchi, Shuji Kanda, Kazunari Yoshida, Yusuke Funaoka, Koji Yamanegi, Kyohei Yoshikawa, Kazuki Takaoka, Hiromitsu Kishimoto, Yoshiro Nakano
Summary: Mucoepidermoid carcinoma (MEC) is the most common malignant tumor of the salivary glands. This study established a low-grade MEC cell line from a patient and found activation of the AREG-EGFR signaling pathway, which may contribute to tumor growth and survival. This cell line could potentially aid in the identification of new strategies for MEC treatment.
MOLECULAR AND CLINICAL ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Maroun Bou Zerdan, Prashanth Ashok Kumar, Daniel Zaccarini, Jeffrey Ross, Richard Huang, Abirami Sivapiragasam
Summary: Salivary gland carcinomas (SGC) are histologically diverse cancers, and next-generation sequencing (NGS) is used to identify key molecular targets. This study found common mutations and potential predictive markers for immunotherapy in SGC through comprehensive genomic profiling (CGP).
Article
Ophthalmology
H. U. Sun, R. O. N. G. R. O. N. G. Cai, C. H. A. N. G. W. E. N. Zhai, W. A. N. J. I. N. G. Song, J. Sun, Y. I. N. G. W. E. N. Bi
Summary: This study evaluated the clinicopathologic and molecular characteristics of lacrimal apparatus mucoepidermoid carcinoma (MEC) to define its typical diagnostic features. The study included 8 cases, with 6 cases occurring in the lacrimal gland and 2 cases in the lacrimal sac and nasolacrimal duct. The histological type and immunohistochemistry results were helpful for definitive diagnosis, and the potential etiologic role of HPV type 6 infection was mentioned.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Oncology
Fang Wang, Shao-Yan Xi, Wen-Wen Hao, Xin-Hua Yang, Ling Deng, Yu-Xia Xu, Xiao-Yan Wu, Liang Zeng, Kai-Hua Guo, Hai-Yun Wang
Summary: This study aimed to investigate the molecular alterations of primary pulmonary salivary gland-type tumors (PSGTs) using targeted next-generation sequencing (NGS). Results showed that MAML2 and MYB rearrangements were detected in a high percentage of MEC and ACC patients. Additionally, ACC patients had mutations enriched in 5 pathways, suggesting potential targeted therapies for improved survival outcomes.
Article
Oncology
Vanita Noronha, Aditya Dhanawat, Vijay Maruti Patil, Nandini Menon, Ajay Kumar Singh, Pankaj Chaturvedi, Prathamesh Pai, Devendra Chaukar, Sarbani Ghosh Laskar, Kumar Prabhash
Summary: Neo-adjuvant chemotherapy has shown long term survival benefits in patients with locally advanced oral cavity squamous cell carcinomas.
Article
Oncology
Andrea Costantino, Claudio Sampieri, Gian Marco Pace, Bianca Maria Festa, Luca Cerri, Giorgio Gregory Giordano, Michael Dale, Giuseppe Spriano, Giorgio Peretti, Armando De Virgilio
Summary: This study aimed to predict the necessity of enteral nutrition at 28 days after surgery in patients with head and neck cancers. The results showed that the machine learning models had optimistic accuracy in predicting the need for enteral nutrition, but had moderate sensitivity.
Article
Oncology
Lirui Zhang, Qiaoshi Xu, Zhien Feng
Summary: This study presents a comprehensive clinical, genomic, and transcriptomic analysis of primary ghost cell odontogenic carcinoma (GCOC). The results provide the first comprehensive molecular atlas for primary GCOC, including previously identified CTNNB1 mutation and novel alterations in MAP3K, EP300, and the 22q11.21 region. The transcriptome analysis reveals significant involvement of cytokine-cytokine receptor interaction and the PI3K-Akt signaling pathway. More GCOC cases should be compared to validate these findings for accurate clinical guidance.
Article
Oncology
Emily Capone, Vittoria Perrotti, Ilaria Cela, Rossano Lattanzio, Lucrezia Togni, Corrado Rubini, Vito Carlo Alberto Caponio, Lorenzo Lo Muzio, Martina Colasante, Francesco Giansanti, Rodolfo Ippoliti, Stefano Iacobelli, Michael J. Wick, Nicole Spardy Burr, Gianluca Sala
Summary: This study explores the potential of galectin-3 binding protein (LGALS3BP) as a novel target for antibody-drug conjugate (ADC) therapy in adenoid cystic carcinoma (ACC). The results show that LGALS3BP is highly expressed in ACC tissues and treatment with anti-LGALS3BP ADC leads to durable tumor growth inhibition in animal models.
Article
Oncology
Andrea Costantino, Claudio Sampieri, Piero Giuseppe Meliante, Armando De Virgilio, Se-Heon Kim
Summary: This study compares the outcomes of transoral resections using the da Vinci SP and da Vinci Xi systems for oropharyngeal squamous cell carcinoma (OPSCC). The results indicate that the da Vinci SP system has advantages in terms of reduced docking and console times, as well as improved rates of wide negative resection margins. However, there were no significant differences in complication rates or postoperative functional outcomes between the two systems.
