Article
Multidisciplinary Sciences
Mayank Bahuguna, Sunila Hooda, Lalit Mohan, Rakesh Kumar Gupta, Prerna Diwan
Summary: The study aims to establish a connection between oral dysbiosis and betel quid chewing habits through a comparison of the oral microbiome of chewers and non-chewing individuals. Analysis of the oral microbiome of 22 adults in Delhi, India, showed significant differences in taxonomic abundance and diversity between chewers and non-chewers. Early chewers exhibited significant changes in their microbial niche, possibly due to exposure to chemicals in betel quid, and long-term chewers showed a unique microenvironment. Investigating the link between oral dysbiosis and oral diseases, including cancers, may lead to the identification of specific microbiome-based markers for early diagnosis.
Article
Substance Abuse
Kanako Yoshikawa, Hiroyuki Yamada, Midori Matsushima
Summary: The study highlights differences in characteristics between betel chewers and tobacco smokers, as well as between betel quid users and heavy users, suggesting the need for a specific prevention strategy for betel quid consumption in Myanmar rather than relying on the existing tobacco prevention strategy.
INTERNATIONAL JOURNAL OF DRUG POLICY
(2021)
Article
Public, Environmental & Occupational Health
Yin Min Aye, S. A. Hong, B. Thepthien, S. Tiraphat
Summary: This study aimed to determine the prevalence of betel quid chewing at national and subnational levels in Myanmar and analyze its associations with tobacco and sociodemographic factors. The study found that the prevalence of betel quid chewing was higher in men and was associated with factors such as age, education, poverty, and living with a spouse. In women, the prevalence was lower and associated with education, living with a spouse, and speaking Myanmar. Tobacco use showed an inverse and positive association with betel quid chewing in men and women, respectively.
JOURNAL OF PUBLIC HEALTH
(2022)
Article
Dentistry, Oral Surgery & Medicine
Gengru Wang, Zhonglin Yu, Tong Ji, Linjun Shi, Wei Liu
Summary: This report provides a comprehensive bibliometric analysis of papers on betel quid (BQ)-related cancer and precancerous lesions. The analysis shows that China, India, United States, and United Kingdom are the major contributors, and Taiwan region remains in the first place. The most frequent research keyword is arecoline, followed by drug, prevalence, metabolism, carcinogenesis, and pathology. The scientific output of BQ-related cancer and precancerous field represents distinct regional characteristics, and Taiwan region is leading in prevention efforts.
JOURNAL OF DENTAL SCIENCES
(2023)
Article
Public, Environmental & Occupational Health
Chandrashekhar T. Sreeramareddy, Saint Nway Aye, Sunil Pazhayanur Venkateswaran
Summary: The prevalence of tobacco use and betel quid chewing is high in Myanmar, especially among men. Interventions for tobacco control should be strictly implemented, and the issue of 'dual use' of both tobacco and betel quid should be urgently addressed. Factors such as age, wealth, and marital status are associated with tobacco use and/or betel quid chewing, with larger effects observed among women in terms of wealth groups.
Review
Dentistry, Oral Surgery & Medicine
Jun Yang, Zi-Yu Wang, Long Huang, Tao-Lin Yu, Shu-Qian Wan, Juan Song, Bing-Liang Zhang, Ming Hu
Summary: The study found a significant association between betel quid and areca nut chewing with poor prognosis in patients with oral cancer, indicating a higher risk of mortality among chewers compared to non-chewers.
Article
Oncology
Cheng-Nan Wu, Wen-Shin Chang, Liang-Chun Shih, Yun-Chi Wang, Hsu-Tung Lee, Chien-Chih Yu, Zhi-Hong Wang, Mei-Chin Mong, Te-Chun Hsia, Chia-Wen Tsai, Da-Tian Bau
Summary: The study found that the percentage of XPC rs2228001 AC and CC genotypes was higher in oral cancer patients compared to controls, suggesting a potential association with oral cancer risk; XPC rs2228000 did not show a significant association with oral cancer; smoking and betel quid chewing behaviors had a synergistic effect with XPC rs2228001 genotype on increasing oral cancer risk; AC/CC carriers of XPC rs2228001 had lower DNA repair capacity than AA carriers.
CANCER GENOMICS & PROTEOMICS
(2021)
Article
Nutrition & Dietetics
Yu-Tsung Chou, Zih-Jie Sun, Wei-Chen Shen, Yi-Ching Yang, Feng-Hwa Lu, Chih-Jen Chang, Chung-Yi Li, Jin-Shang Wu
Summary: Betel quid chewing is associated with liver fibrosis, and metabolic syndrome increases the risk of liver fibrosis.
FRONTIERS IN NUTRITION
(2022)
Article
Immunology
Osamu Uehara, Daichi Hiraki, Yasuhiro Kuramitsu, Hirofumi Matsuoka, Rie Takai, Mari Fujita, Fumiya Harada, Durga Paudel, Shuhei Takahashi, Koki Yoshida, Malsantha Muthumala, Hiroki Nagayasu, Itsuo Chiba, Yoshihiro Abiko
Summary: The study revealed that the oral flora of betel quid chewers differs from non-chewers, with a higher proportion of periodontal pathogens and a lower proportion of cariogenic pathogens in the former group. Additionally, there was a significant difference in the diversity index of oral flora between betel quid chewers and non-chewers.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2021)
Review
Biochemistry & Molecular Biology
Nicola Cirillo, Peter Hung Duong, Wee Teng Er, Casey Thao Nhi Do, Manikkuwadura Eranda Harshan De Silva, Yining Dong, Sok Ching Cheong, Elizabeth Fitriana Sari, Michael J. McCullough, Pangzhen Zhang, Stephen S. Prime
Summary: Oral submucous fibrosis (OSF) is a potentially malignant condition characterized by progressive fibrosis of the oral cavity. The use of betel quid (BQ) is typically associated with OSF, and the chemical properties of different BQ recipes vary, potentially explaining the unequal prevalence of OSF and oral cancer in BQ users. The review found that chewing BQ mixtures containing betel inflorescence (BI) and tobacco significantly increased the risk of OSF, while the use of betel leaf was likely to be protective.
Article
Oncology
Yi-Hong Liu, Yu-Lian Chen, Ting-Yu Lai, Ying-Chieh Ko, Yu-Fu Chou, Peir-Rong Chen, Jenn-Ren Hsiao, Jang-Yang Chang, Shine-Gwo Shiah, Jeng-Woei Lee, Jia-Ling Yang, Su-Fang Lin
Summary: Partial epithelial-mesenchymal transition (p-EMT) is a common feature in oral cavity tumors, requiring support from tumor stroma. Through gene set enrichment analysis and immunohistochemistry validation, molecular characteristics of different tumor types were identified. TGFBI and HYAL1 serve as prognostic biomarkers for oral cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, General & Internal
Hui-Jun Lin, Xiao-Lei Wang, Meng-Yuan Tian, Xing-Li Li, Hong-Zhuan Tan
Summary: There is a significant relationship between betel quid chewing, alcohol consumption, smoking, and oral potential malignant disorders (OPMDs). Furthermore, smoking and alcohol drinking enhance the association between betel quid chewing and OPMDs.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Review
Oncology
Hui-Ching Chuang, Ming-Hsien Tsai, Yu-Tsai Lin, Ming-Huei Chou, Kun-Lin Yang, Chih-Yen Chien
Summary: The major predisposing factors of developing oral cancer include smoking, alcohol drinking, and betel quid chewing. Betel quid chewing could cause oral mucosa damage and lead to precancerous lesions and trismus. Betel quid-related oral cancer patients also have more systemic diseases than those without this habit. More attention should be paid to pretreatment evaluation, treatment strategy, and posttreatment follow-up among betel quid chewers.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2022)
Article
Health Care Sciences & Services
Chun-Kai Chang, Jia-In Lee, Chu-Fen Chang, Yung-Chin Lee, Jhen-Hao Jhan, Hsun-Shuan Wang, Jung-Tsung Shen, Yao-Hsuan Tsao, Shu-Pin Huang, Jiun-Hung Geng
Summary: Betel nut chewing is associated with an increased risk of kidney stone disease, particularly among individuals who chew more than 30 quids per day.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Medicine, Research & Experimental
Mohit Sharma, Mandana Donoghue, Radhika Pathiyal, Raghu Radhakrishnan
Summary: Oral submucous fibrosis is an irreversible, progressive, potentially malignant condition that develops among habitual areca nut chewers. The active ingredient, nicotine, in tobacco is addictive, and the chronic use of chewing tobacco increases the risk of mouth cancer.
MEDICAL HYPOTHESES
(2022)
