4.1 Review

The Impact of Contact Angle on the Biocompatibility of Biomaterials

期刊

OPTOMETRY AND VISION SCIENCE
卷 87, 期 6, 页码 387-399

出版社

LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/OPX.0b013e3181da863e

关键词

biomaterials; biocompatibility; wettability; contact angle; hydrophilic; hydrophobic

向作者/读者索取更多资源

Biomaterials may be defined as artificial materials that can mimic, store, or come into close contact with living biological cells or fluids and are becoming increasingly popular in the medical, biomedical, optometric, dental, and pharmaceutical industries. Within the ophthalmic industry, the best example of a biomaterial is a contact lens, which is worn by similar to 125 million people worldwide. For biomaterials to be biocompatible, they cannot illicit any type of unfavorable response when exposed to the tissue they contact. A characteristic that significantly influences this response is that related to surface wettability, which is often determined by measuring the contact angle of the material. This article reviews the impact of contact angle on the biocompatibility of tissue engineering substrates, blood-contacting devices, dental implants, intraocular lenses, and contact lens materials. (Optom Vis Sci 2010; 87: 387-399)

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.1
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

Article Ophthalmology

Lipid deposition on contact lenses in symptomatic and asymptomatic contact lens wearers

Negar Babaei Omali, Lakshman. N. Subbaraman, Miriam Heynen, Mark Lada, Kristy Canavan, Zohra Fadli, William Ngo, Lyndon Jones

Summary: Lipid deposition was significantly higher in the asymptomatic group compared to symptomatic wearers. Cholesteryl ester deposition was found to be the highest among all lipid types. Although the measured lipid levels are considered low for clinical deposition, they may impact other clinical outcomes such as comfort.

CONTACT LENS & ANTERIOR EYE (2021)

Article Biotechnology & Applied Microbiology

The Effect of Antimicrobial Peptides on the Viability of Human Corneal Epithelial Cells

Ezgi Ulkuseven, David J. McCanna, Lakshman N. Subbaraman, Lyndon W. Jones

Summary: Antimicrobial peptides are a class of polypeptides composed of less than 100 amino acids, demonstrating strong activity against infectious bacteria. Among the peptides studied, polymyxin E and nisin showed potential for treating ocular infections with low toxicity to human corneal epithelial cells.

PROBIOTICS AND ANTIMICROBIAL PROTEINS (2021)

Review Ophthalmology

The impact of patient behaviour and care system compliance on reusable soft contact lens complications

Alan Yee, Karen Walsh, Marc Schulze, Lyndon Jones

Summary: Reusable soft contact lenses continue to be popular among wearers, but the additional steps required for cleaning and disinfecting may lead to non-compliant behavior and potentially impact wearers' health. Educating patients, regulating the use of contact lens care solutions, and reevaluating global standards are key strategies to better support contact lens wearers.

CONTACT LENS & ANTERIOR EYE (2021)

Article Ophthalmology

Clinical practice patterns in the management of dry eye disease: A TFOS international survey

James S. Wolffsohn, Sonia Trave Huarte, Lyndon Jones, Jennifer P. Craig, Michael T. M. Wang

Summary: The survey revealed variations in the management of dry eye disease by eye care practitioners across continents and countries, with different prescription patterns for different severity levels and subtypes. Different management strategies are utilized for evaporative and aqueous deficient dry eye disease, indicating the need for tailored approaches based on individual patient needs.

OCULAR SURFACE (2021)

Editorial Material Ophthalmology

Bibliometric analysis of the meibomian gland literature

Jason J. Nichols, Lyndon W. Jones, Philip B. Morgan, Nathan Efron

OCULAR SURFACE (2021)

Article Ophthalmology

The Impact of Incubation Conditions on In Vitro Phosphatidylcholine Deposition on Contact Lens Materials

Hendrik Walther, Holly Lorentz, Miriam Heynen, Lise Kay, Lyndon W. Jones

Summary: This study examined the impact of incubation time, lipid concentration, and ATS replenishment on the uptake of phosphatidylcholine onto CH and SH contact lens materials. The results showed that all materials exhibited increasing PC deposition over time, with SH materials having higher uptake rates than CH materials. Increasing lipid concentration in the ATS resulted in increased PC binding onto the contact lens materials, while regular replenishment of the ATS showed different impacts on PC deposition for CH and SH materials.

OPTOMETRY AND VISION SCIENCE (2021)

Article Ophthalmology

Bibliometric analysis of the literature relating to scleral contact lenses

Nathan Efron, Lyndon W. Jones, Phillip B. Morgan, Jason J. Nichols

CONTACT LENS & ANTERIOR EYE (2021)

Article Ophthalmology

In vitro analysis of the interaction of tear film inflammatory markers with contemporary contact lens materials

Parisa Mirzapour, David J. McCanna, Lyndon Jones

Summary: This study investigated the uptake of four pro-inflammatory cytokines onto six contemporary contact lens materials. It was found that both conventional hydrogels and two of the four silicone hydrogels tested showed some uptake of certain cytokines, while senofilcon A and somofilcon A did not exhibit uptake of any. Overall, the tested contact lens materials did not show significant uptake of IL-6 and had limited uptake of IL-1 beta, IL-8, or TNF-alpha.

CONTACT LENS & ANTERIOR EYE (2021)

Article Ophthalmology

CLEAR-Contact lens technologies of the future

Lyndon Jones, Alex Hui, Chau-Minh Phan, Michael L. Read, Dimitri Azar, John Buch, Joseph B. Ciolino, Shehzad A. Naroo, Brian Pall, Kathleen Romond, Padmaja Sankaridurg, Cristina M. Schnider, Louise Terry, Mark Willcox

Summary: Contact lenses in the future may have functions beyond correcting refractive errors, such as detecting systemic and ocular diseases, treating various eye conditions, correcting presbyopia, and controlling the development of myopia. Advancements in technology have led to the development of contact lenses as drug delivery devices and powered through nanotechnology. Challenges remain in integrating sensors into contact lenses and optimizing drug delivery to the ocular surface.

CONTACT LENS & ANTERIOR EYE (2021)

Article Ophthalmology

The impact of contact lenses on meibomian gland morphology

Eugene Appenteng Osae, Lyndon Jones, Jason J. Nichols

Summary: This review summarizes the evidence on how contact lens wear affects the morphology and secretion of the meibomian glands, with key factors such as duration, type, design, and material of the lenses influencing the extent of these changes.

OCULAR SURFACE (2022)

Article Microbiology

Antiviral Activity of Contemporary Contact Lens Care Solutions against Two Human Seasonal Coronavirus Strains

Christiane Lourenco Nogueira, Scott Joseph Boegel, Manish Shukla, William Ngo, Lyndon Jones, Marc G. Aucoin

Summary: This study investigated the impact of different contact lens care products on the infectiousness of two seasonal human coronaviruses. The results showed that oxidative disinfection systems exhibited significant virucidal activity, while non-oxidative systems showed minimal ability to inactivate the viruses.

PATHOGENS (2022)

Article Ophthalmology

Short-term tolerability of commercial eyelid cleansers: A randomised crossover study

Jennifer P. Craig, Etty Bitton, Jaya Dantam, Lyndon Jones, William Ngo, Michael T. M. Wang

Summary: This study evaluated the short-term tolerability of five commercially available anti-demodectic eyelid cleansers, finding that different cleanser formulations may induce ocular discomfort, tear film instability, conjunctival hyperaemia, and ocular surface staining during application.

CONTACT LENS & ANTERIOR EYE (2022)

Article Instruments & Instrumentation

In vitro-in vivo correlation of drug release profiles from medicated contact lenses using an in vitro eye blink model

Ana F. F. Pereira-da-Mota, Maria Vivero-Lopez, Piyush Garg, Chau-Minh Phan, Angel Concheiro, Lyndon Jones, Carmen Alvarez-Lorenzo

Summary: This study aimed to evaluate the release profiles of two drug-loaded contact lenses (CLs) in a 3D in vitro eye blink model and compare them with in vivo profiles. The results showed that the release of both drugs was more sustained and lower in the 3D eye model compared to in vitro release in vials. The findings suggest that the current 3D printed eye blink model could be a useful tool to measure the release of ophthalmic drugs from medicated CLs, but further optimization is needed.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2023)

Article Ophthalmology

TFOS Lifestyle: Impact of contact lenses on the ocular surface

Lyndon Jones, Nathan Efron, Kalika Bandamwar, Melissa Barnett, Deborah S. Jacobs, Isabelle Jalbert, Heiko Pult, Michelle K. Rhee, Heather Sheardown, Joseph P. Shovlin, Ulli Stahl, Adriana Stanila, Jacqueline Tan, Silvia Tavazzi, Omur O. Ucakhan, Mark D. P. Willcox, Laura E. Downie

Summary: The lifestyle choices of contact lens wearers can have negative impacts on eye health, such as poor adherence to care, sleeping in lenses, inappropriate purchases, lack of regular aftercare visits, wearing lenses while feeling unwell, wearing lenses too soon after surgery, and wearing lenses during risky behaviors. However, contact lenses can also provide therapeutic benefits. The COVID-19 pandemic introduced new challenges for contact lens wearers, including mask-associated dry eye, increased discomfort from digital device use, accidental exposure to hand sanitizers, and reduced lens usage.

OCULAR SURFACE (2023)

Article Ophthalmology

Activity of Deposited Lysozyme on Contemporary Soft Contact Lenses Exposed to Differing Lens Care Systems

Miriam Heynen, Alan Ng, Elizabeth Martell, Lakshman N. Subbarannan, Lyndon Jones

Summary: The study found that there was no significant difference in the amount and activity of protein and lysozyme deposits on contact lenses between the peroxide-based system and the polyquaternium-1 and myristamidopropyl dimethylamine-containing system. However, the peroxide-based system showed a slightly lower total lysozyme deposition compared to the polyquaternium-1 and myristamidopropyl dimethylamine-containing system.

CLINICAL OPHTHALMOLOGY (2021)

暂无数据