期刊
OPTICS LETTERS
卷 39, 期 9, 页码 2790-2793出版社
OPTICAL SOC AMER
DOI: 10.1364/OL.39.002790
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资金
- Wallenberg Foundation
- Swedish Research Council
We demonstrate that nanoparticle x-ray fluorescence computed tomography in mouse-sized objects can be performed with very high spatial resolution at acceptable dose and exposure times with a compact laboratory system. The method relies on the combination of the 24 keV line-emission from a high-brightness liquid-metal-jet x-ray source, pencil-beam-forming x-ray optics, photon-counting energy-dispersive detection, and carefully matched (Mo) nanoparticles. Phantom experiments and simulations show that the arrangement significantly reduces Compton background and allows 100 mu m detail imaging at dose and exposure times compatible with small-animal experiments. The method provides a possible path to in vivo molecular x-ray imaging at sub-100 mu m resolution in mice. (C) 2014 Optical Society of America
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