Article
Optics
Senyue Hao, Chao Ren, Fei Wang, Kibeom Park, Brett D. Volmert, Aitor Aguirre, Chao Zhou
Summary: To study the three-dimensional microstructure and calcium dynamics of human heart organoids (hHOs), a dual-modality imaging system combining optical coherence tomography (OCT) and fluorescence microscopy was developed. OCT provided high-resolution structural information while fluorescence imaging indicated the electrophysiology of the hHOs' beating behavior. This imaging platform proved to be a powerful tool for studying and assessing hHOs in vitro, with potential applications in disease modeling and drug screening.
Article
Biochemical Research Methods
Cai Li, Julien Bec, Xiangnan Zhou, Laura Marcu
Summary: This study designs and characterizes a robust multimodal imaging system that combines optical coherence tomography and multispectral fluorescence lifetime imaging. By adopting key features, the system addresses existing shortcomings and achieves excellent experimental results.
JOURNAL OF BIOMEDICAL OPTICS
(2022)
Article
Biochemistry & Molecular Biology
Eric Yi-Hsiu Huang, Meng-Chun Kao, Chien-Kun Ting, William J. S. Huang, Yi-Ting Yeh, Hui-Hsuan Ke, Wen-Chuan Kuo
Summary: This study describes a method of real-time visual detection of peritoneal placement of the Veress needle using an incorporated optical coherence tomography (OCT) probe. The success rate of 97.5% was achieved with the guidance of OCT images. OCT images translate the blind closed technique of peritoneal access into a visualized procedure, thus improving peritoneal access safety.
Article
Biochemical Research Methods
Jeffrey M. Mcbride, Michael J. Hackmann, Sophia Nimphius, Barry Cense
Summary: This study investigates the feasibility of using a polarizatio-sensitive optical coherence tomography (PS-OCT) needle probe to accurately identify anatomical structures in human skeletal muscle. The results suggest that the PS-OCT needle probe can be inserted into live human skeletal muscle and identify relevant anatomical structures, potentially serving as a diagnostic tool for skeletal muscle pathology.
BIOMEDICAL OPTICS EXPRESS
(2022)
Article
Chemistry, Multidisciplinary
Amalia Coro, Ada Herrero Ruiz, Mateo Pazo-Gonzalez, Alonso Sanchez-Cruz, Tobias Busch, Alejandro Hernandez Medel, Erving C. Ximendes, Dirk H. Ortgies, Rosalia Lopez-Mendez, Ana Espinosa, Dorleta Jimenez de Aberasturi, Daniel Jaque, Nuria Fernandez Monsalve, Enrique J. de la Rosa, Catalina Hernandez-Sanchez, Emma Martin Rodriguez, Beatriz H. Juarez
Summary: In this study, the application of Ag2S nanoparticles in ocular imaging was extended by preparing them with a biocompatible amphiphilic block copolymer. This method protects the photoluminescence properties of the nanoparticles and allows for the controlled preparation of submicrometric scattering centers, enhancing colloidal stability and biocompatibility. The resulting nanoparticles exhibit improved contrast for optical coherence tomography and near-infrared imaging.
Article
Engineering, Electrical & Electronic
Zhiwei Yang, Xu Wu, Jihong Pei, Shuangchen Ruan
Summary: By improving the structure of FDML wavelength-swept laser source, deeper imaging depth and higher axial resolution can be achieved. The application of a Brillouin fiber laser structure and combined dual-cavity FDML configuration allows the new ring resonator arrangement to play an important role in optical coherence tomography.
JOURNAL OF LIGHTWAVE TECHNOLOGY
(2022)
Article
Ophthalmology
Matteo Menean, Riccardo Sacconi, Beatrice Tombolini, Federico Fantaguzzi, Francesco Bandello, Giuseppe Querques
Summary: This study aimed to detect retinal neovascularization elsewhere (NVE), of the optic disc (NVD) and intraretinal microvascular abnormalities (IRMA) in treatment naive diabetic retinopathy (DR) using wide-field colour fundus photography (WF CFP), wide-field spectral-domain optical coherence tomography angiography (OCTA) and the combination of WF CFP and OCTA through overlay software. The results showed that OCTA had high levels of agreement in detecting NVE, NVD and IRMA, and combining WF CFP and OCTA further improved the detection of NVE and NVD.
Article
Biochemical Research Methods
Alexandre Abid, Renaud Duval, Christos Boutopoulos
Summary: A method to encase OCT probes into polyimide subretinal injection cannulas was introduced and validated. The system achieved a high success rate of 95.0% for subretinal injection, with a significant portion of the injected volume reaching the subretinal space.
BIOMEDICAL OPTICS EXPRESS
(2022)
Article
Engineering, Biomedical
Rui Liu, Qingchen Li, Feiping Xu, Shasha Wang, Jie He, Yiting Cao, Fei Shi, Xinjian Chen, Jili Chen
Summary: AI-based screening for diabetic retinopathy and macular edema using fundus photos and OCT images shows high sensitivity and specificity in a community hospital.
BIOMEDICAL ENGINEERING ONLINE
(2022)
Article
Chemistry, Multidisciplinary
ByungKun Lee, Sunhong Jeong, Joosung Lee, Tae Shik Kim, Boy Braaf, Benjamin J. J. Vakoc, Wang-Yuhl Oh
Summary: This work demonstrates 3D depth-invariant cellular-resolution imaging of the living human retina over a 3 x 3 mm field of view using the first intrinsically phase-stable multi-MHz retinal swept-source OCT and novel computational methods. It provides wide-field 3D cellular-resolution imaging in the human retina, which can bring a great impact in clinical ophthalmology.
Article
Biochemical Research Methods
Minghui Chen, Jianping Wang, Weijie Tan, Yuanyuan Feng, Gang Zheng
Summary: The novel all-fiber probe presented in this study, combining optical coherence tomography and pH detection, is designed to accurately and quickly determine whether biological tissue is cancerous, with high resolution and measurement accuracy.
JOURNAL OF BIOPHOTONICS
(2021)
Review
Chemistry, Multidisciplinary
Ramadhan Hardani Putra, Nobuhiro Yoda, Eha Renwi Astuti, Keiichi Sasaki
Summary: The literature reviewed demonstrates that OCT has the capability to visualize periodontal and peri-implant conditions with high resolution. However, there is a lack of clinical evidence supporting OCT as a dental optical probe for imaging the subgingival area. Further development of handheld OCT systems and controlled clinical trials are needed to confirm its imaging capability in dentistry.
APPLIED SCIENCES-BASEL
(2021)
Article
Optics
Zhiwei Yang, Xu Wu, Jihong Pei, Shuangchen Ruan
Summary: This paper introduces a novel driving method of fiber Fabry-Perot tunable filter (FFP-TF) using a dual-sinusoidal signal, which can increase the bandwidth of wavelength-swept laser sources and improve the axial resolution.
OPTICS AND LASER TECHNOLOGY
(2022)
Article
Acoustics
Ruiming Kong, Cuixia Dai, Qi Zhang, Lei Gao, Zhuoquan Chen, Yuting Song, Zhengjie Wu, Jiming Wang, Shuo Wang, Hairong Zheng, Teng Ma
Summary: In this study, a tri-modality imaging system integrating ultrasound, optical coherence tomography (OCT), and near-infrared fluorescence (NIRF) was presented for pancreaticobiliary duct imaging. The system showed promising imaging performance in mechanism studies, early diagnosis, and prognosis evaluation of malignant pancreaticobiliary carcinomas. The imaging accuracy was validated by correlating the tomography images with histology results.
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2022)
Article
Ophthalmology
Jeremie Villaret, Marie-Helene Errera, Jose-Alain Sahel, Alain Gaudric, Sarah Mrejen, Michel Paques
Summary: The study aimed to comprehensively analyze multimodal imaging findings in patients with ASPPC and highlight the value of ICGA for the diagnosis of ASPPC. It was found that ASPPC could be caused by retinal pigment epithelium dysfunction and was characterized by hypofluorescence visible only on late-phase ICGA.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Patrick K. Capon, Jiawen Li, Aimee J. Horsfall, Suliman Yagoub, Erik P. Schartner, Asma Khalid, Rodney W. Kirk, Malcolm S. Purdey, Kylie R. Dunning, Robert A. McLaughlin, Andrew D. Abell
Summary: A new fiber functionalization architecture enables simultaneous imaging and sensing, providing significant insights into complex biological systems.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Review
Cardiac & Cardiovascular Systems
Jiawen Li, Nicholas J. Montarello, Ayla Hoogendoorn, Johan W. Verjans, Christina A. Bursill, Karlheinz Peter, Stephen J. Nicholls, Robert A. McLaughlin, Peter J. Psaltis
Summary: This review examines emerging hybrid intracoronary imaging techniques and discusses their strengths, limitations, and potential for clinical translation, aiming to advance clinical approaches for predicting atherothrombotic events and improving the treatment of coronary atherosclerosis.
JACC-CARDIOVASCULAR IMAGING
(2022)
Article
Engineering, Biomedical
Julia Walther, Jonas Golde, Marius Albrecht, Bryden C. Quirk, Loretta Scolaro, Rodney W. Kirk, Yuliia Gruda, Christian Schnabel, Florian Tetschke, Korinna Joehrens, Dominik Haim, Michaela Buckova, Jiawen Li, Robert A. McLaughlin
Summary: This study presents a highly miniaturized, handheld probe developed for rapid assessment of soft tissue using optical coherencetomography (OCT). The probe combines an all-fiber optical design with a light-weight magnetic scanning mechanism to provide easy access to the oral cavity. The results demonstrate the feasibility of using a small, lightweight probe to identify pathological features in oral soft tissue.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2022)
Article
Instruments & Instrumentation
Rachel Lloyd, Jane Walter, Sarah Pirikahu, Gemma Cadby, Martha Hickey, David D. Sampson, Karol Karnowski, Michael J. Hackmann, Christobel Saunders, Lothar Lilge, Jennifer Stone
Summary: Mammographic breast density is a significant risk factor for breast cancer, and optical breast spectroscopy (OBS) is a promising method for measuring breast density. This study validates the participant data of OBS and confirms its effectiveness in epidemiological research.
REVIEW OF SCIENTIFIC INSTRUMENTS
(2022)
Article
Chemistry, Multidisciplinary
Jiawen Li, Simon Thiele, Rodney W. Kirk, Bryden C. Quirk, Ayla Hoogendoorn, Yung Chih Chen, Karlheinz Peter, Stephen J. Nicholls, Johan W. Verjans, Peter J. Psaltis, Christina Bursill, Alois M. Herkommer, Harald Giessen, Robert A. McLaughlin
Summary: Multimodal microendoscopes enable simultaneous structural and molecular measurements in vivo, providing valuable insights into pathological changes associated with diseases. However, different optical imaging modalities have conflicting requirements for lens design, posing a challenge for the fabrication of miniaturized imaging probes. This study demonstrates an optical design using two-photon 3D printing to create a miniaturized lens that is optimized for both fluorescence and optical coherence tomography (OCT) imaging. The lens-in-lens design shows significant improvement in fluorescence sensitivity compared to conventional fiber-optic design approaches, and is successfully integrated into an intravascular catheter probe for simultaneous OCT and fluorescence imaging of a mouse artery in vivo.
Review
Optics
Danuta M. Sampson, Adam M. Dubis, Fred K. Chen, Robert J. Zawadzki, David D. Sampson
Summary: The visualization and assessment of retinal microvasculature are crucial in the study and treatment of eye and systemic diseases. However, the current methods and analysis of OCTA imaging lack consistency, hindering progress. This paper proposes steps to standardize OCTA imaging, including imaging protocols, data analysis methods, metrics, reporting, and clinical practice, to address these limitations.
LIGHT-SCIENCE & APPLICATIONS
(2022)
Article
Biochemical Research Methods
Loretta Scolaro, Dirk Lorenser, Bryden C. Quirk, Rodney W. Kirk, Louisa A. Ho, Elizabeth Thomas, Jiawen Li, Christobel M. Saunders, David D. Sampson, Rebecca O. Fuller, Robert A. McLaughlin
Summary: This article introduces a multimodal imaging needle that can differentiate cell types through simultaneous optical coherence tomography (OCT) and fluorescence imaging. By conducting experiments on ER+ and ER- breast cancer cells, it is demonstrated that this miniaturized imaging probe can successfully image live cells and differentiate cancer cells.
JOURNAL OF BIOMEDICAL OPTICS
(2022)
Article
Engineering, Electrical & Electronic
Karol Karnowski, Gavrielle Untracht, Michael Hackmann, Onur Cetinkaya, David Sampson
Summary: This study explores the use of a side-viewing probe combining graded-index fiber and a ball lens, which demonstrates superior performance in optical imaging. Through detailed analysis and modeling, it is shown that this probe design offers excellent performance across various numerical apertures and opens up new possibilities for broader imaging applications.
IEEE PHOTONICS JOURNAL
(2022)
Article
Multidisciplinary Sciences
Anastasiya Starovoyt, Bryden C. Quirk, Tristan Putzeys, Greet Kerckhofs, Johan Nuyts, Jan Wouters, Robert A. McLaughlin, Nicolas Verhaert
Summary: This study presents an image-guided cochlear implant device that uses optical imaging to provide real-time feedback during surgery, helping surgeons accurately insert the electrode array and avoid damaging residual hearing function.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Gavrielle R. Untracht, Nikolaos Dikaios, Abdullah K. Durrani, Mariam Bapir, Marinko V. Sarunic, David D. Sampson, Christian Heiss, Danuta M. Sampson
Summary: This pilot study evaluates OCTA-derived microvascular parameters in healthy individuals and patients with diabetes. It establishes reference values for different regions of the body and identifies potential biomarkers for diabetes.
SCIENTIFIC REPORTS
(2023)
Article
Biology
Mariam Bapir, Gavrielle R. R. Untracht, Julie E. A. Hunt, John H. H. McVey, Jenny Harris, Simon S. S. Skene, Paola Campagnolo, Nikolaos Dikaios, Ana Rodriguez-Mateos, David D. D. Sampson, Danuta M. M. Sampson, Christian Heiss
Summary: Endothelial function in the femoral artery and brachial artery is similarly affected by age in healthy adults, leading to an increased susceptibility to peripheral artery disease in old age.
Article
Oncology
Rachel Lloyd, Sarah Pirikahu, Jane Walter, Gemma Cadby, Ellie Darcey, Dilukshi Perera, Martha Hickey, Christobel Saunders, Karol Karnowski, David D. Sampson, John Shepherd, Lothar Lilge, Jennifer Stone
Summary: This study examines the acceptability and performance of two alternative breast density measures, Optical Breast Spectroscopy (OBS) and Dual X-ray Absorptiometry (DXA), in women aged 18-40. The results showed that over 93% of participants deemed OBS and DXA to be acceptable. The correlation between OBS-%water + collagen and %FGV was 0.48, and age and BMI were associated with breast density measures.
BRITISH JOURNAL OF CANCER
(2023)
Article
Optics
Martin Poinsinet De Sivry-Houle, Nicolas Godbout, Caroline Boudoux
Summary: Mie scattering simulations are crucial for designing sensing and imaging devices in atmospheric and biomedical sciences. PyMieSim is a fast, flexible, and highly visual simulation package that allows for the study of various parameters in different configurations.
Review
Multidisciplinary Sciences
Brett E. Bouma, Johannes F. de Boer, David Huang, Ik-Kyung Jang, Taishi Yonetsu, Cadman L. Leggett, Rainer Leitgeb, David D. Sampson, Melissa Suter, Ben J. Vakoc, Martin Villiger, Maciej Wojtkowski
Summary: This article introduces the principles, applications, and future prospects of optical coherence tomography (OCT). By explaining the principles and origins of signals for different instrument configurations, as well as image processing and interpretation methods, the article comprehensively analyzes the application of OCT in biological and medical imaging.
NATURE REVIEWS METHODS PRIMERS
(2022)
Article
Biochemistry & Molecular Biology
Mariam Bapir, Gavrielle R. Untracht, Debbie Cooke, John H. McVey, Simon S. Skene, Paola Campagnolo, Martin B. Whyte, Nikolaos Dikaios, Ana Rodriguez-Mateos, David D. Sampson, Danuta M. Sampson, Christian Heiss
Summary: This study found that individuals with type 2 diabetes mellitus (T2DM) exhibit greater impairment in femoral artery endothelial function and dermal microcirculation. The consumption of cocoa flavanol (CF) improves endothelial function in both healthy individuals and those with T2DM, who are at increased risk of developing lower extremity peripheral artery disease (PAD) and foot ulcers.