期刊
OPTICS LETTERS
卷 35, 期 8, 页码 1257-1259出版社
OPTICAL SOC AMER
DOI: 10.1364/OL.35.001257
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资金
- Natural Science and Engineering Research Council of Canada
- Canadian Foundation for Innovation
- Canadian Institutes of Health Research
- Cancer Imaging Network Ontario
We optimize speckle variance optical coherence tomography (svOCT) imaging of microvasculature in high and low bulk tissue motion scenarios. To achieve a significant level of image contrast, frame rates must be optimized such that tissue displacement between frames is less than the beam radius. We demonstrate that higher accuracy estimates of speckle variance can enhance the detection of capillaries. These findings are illustrated in vivo by imaging the dorsal window chamber model ( low bulk motion). We also show svOCT imaging of the nonstabilized finger (high bulk motion), using optimized imaging parameters, demonstrating better vessel detection than Doppler OCT. (C) 2010 Optical Society of America
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