期刊
OPTICS EXPRESS
卷 19, 期 24, 页码 24530-24539出版社
OPTICAL SOC AMER
DOI: 10.1364/OE.19.024530
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- National Science Council, Taipei, Taiwan [100-2120-M-007-006, 100-2221-E-001-010-MY3]
Chip-based biosensors for sensitive label-free detection were fabricated and tested by using Fano-type resonant nanostructures. The sensor was composed of a 190nm-thick gold nanoslit surrounded by 600nm-period grooves. Transverse-magnetic polarized wave in these gold nanostructures generated asymmetrical resonant spectra due to the interference of broad-band cavity resonance in the single slit and narrow-band surface plasmon resonance on the periodic grooves. Compared to nanoslit arrays, such Fano-type sensor has a sharper resonance which yields a figure of merit up to 48. In addition, the crossed talk between sensing elements is reduced due to the Bragg reflection of the periodic grooves. A smaller detection separation down to 10 mu m width was achieved. An antigen-antibody interaction experiment in aqueous environment verified the detection sensitivity in surface binding event. (C) 2011 Optical Society of America
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