期刊
OPTICS EXPRESS
卷 18, 期 12, 页码 12513-12525出版社
OPTICAL SOC AMER
DOI: 10.1364/OE.18.012513
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资金
- Stanford University Beckman Center for Molecular and Genetic Medicine
- National Cancer Institute ICMIC [P50 CA114747]
- University of Toronto
- Natural Sciences and Engineering Research Council of Canada (NSERC) [RGPIN-355623-08]
- Networks of Centres of Excellence of Canada
- Canadian Institute for Photonic Innovations (CIPI)
- NSF
- DARPA-MTO
- National Defense Science and Engineering Graduate (NDSEG)
- U.S. Department of Homeland Security
- SPIE
We have fabricated miniature implantable fluorescence sensors for continuous fluorescence sensing applications in living subjects. These monolithically integrated GaAs-based sensors incorporate a 675nm vertical-cavity surface-emitting laser (VCSEL), a GaAs PIN photodiode, and a fluorescence emission filter. We demonstrate high detection sensitivity for Cy5.5 far-red dye (50 nanoMolar) in living tissue, limited by the intrinsic background autofluorescence. These low cost, sensitive and scalable sensors are promising for long-term continuous monitoring of molecular dynamics for biomedical studies in freely moving animals. (C) 2010 Optical Society of America
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