期刊
OPTICS EXPRESS
卷 18, 期 3, 页码 3079-3092出版社
Optica Publishing Group
DOI: 10.1364/OE.18.003079
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资金
- Wallace H. Coulter Foundation
- National Institutes of Health [HL085939, HL083048, RR1246]
Currently, cardiac radiofrequency ablation (RFA) is guided by indirect signals. We demonstrate optical coherence tomography (OCT) characterization of RFA lesions within swine ventricular wedges. Untreated tissue exhibited a consistent birefringence artifact within OCT images due to the organized myocardium, which was not present in treated tissue. Birefringence artifacts were detected by filtering with a Laplacian of Gaussian (LoG) to quantify gradient strength. The gradient strength distinguished RFA lesions from untreated sites (p=5.93x10(-15)) with a sensitivity and specificity of 94.5% and 86.7% respectively. This study demonstrates the potential of OCT for monitoring cardiac RFA, confirming lesion formation and providing feedback to avoid complications. (C) 2009 Optical Society of America
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