Article
Biochemical Research Methods
Vladimir Y. Zaitsev, Alexander A. Sovetsky, Alexander L. Matveyev, Lev A. Matveev, Dmitry Shabanov, Victoria Y. Salamatova, Pavel A. Karavaikin, Yuri V. Vassilevski
Summary: Compression Optical Coherence Elastography (C-OCE) has made impressive progress in diverse biomedical applications, particularly in nondestructive characterization of human pericardium biomechanics. This technique allows spatially resolved characterization of elasticity in thin samples and provides nonlinear stress-strain data, which is valuable for aortic valve replacement in cardio-surgery.
JOURNAL OF BIOPHOTONICS
(2023)
Review
Biochemical Research Methods
Chongyang Wang, Jiang Zhu, Jiawei Ma, Xiaochen Meng, Zongqing Ma, Fan Fan
Summary: The biomechanical characterization of tissues is important for determining pathological status and assessing disease treatment. Optical coherence elastography (OCE) is a high-resolution imaging technique that can map the spatial elasticity distribution of biological tissue. This article reviews OCE methods and summarizes its current applications in biomedicine.
JOURNAL OF BIOPHOTONICS
(2023)
Article
Biotechnology & Applied Microbiology
Gongpu Lan, Qun Shi, Yicheng Wang, Guoqin Ma, Jing Cai, Jinping Feng, Yanping Huang, Boyu Gu, Lin An, Jingjiang Xu, Jia Qin, Michael D. Twa
Summary: This study analyzed the natural frequency of corneal tissue using optical coherence tomography-based elastography. The results showed that the natural frequency can reveal local variations in tissue structure and can differentiate different types of tissues. This method could provide additional information on corneal properties and be a useful tool for clinical detection of ocular disease and evaluation of treatment outcomes.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Biochemical Research Methods
Vladimir Y. Zaitsev, Alexander L. Matveyev, Lev A. Matveev, Alexander A. Sovetsky, Matt S. Hepburn, Alireza Mowla, Brendan F. Kennedy
Summary: Over the past two decades, quantitative mapping of deformation and elasticity in optical coherence tomography has been a focus of research, and it took about 15 years to demonstrate optical coherence elastography as a useful technique. Compression OCE and shear-wave-based OCE have developed in parallel, with recent breakthroughs in quantitative mapping in Compression OCE but insufficient attention in reviews.
JOURNAL OF BIOPHOTONICS
(2021)
Article
Biochemical Research Methods
Achuth Nair, Manmohan Singh, Salavat Aglyamov, Kirill Larin
Summary: This study demonstrates that heartbeat optical coherence elastography can assess the mechanical properties of the cornea in vivo without external excitation, by detecting Hb-induced deformations and distinguishing corneal stiffness between untreated and crosslinked tissue.
JOURNAL OF BIOMEDICAL OPTICS
(2021)
Article
Biophysics
Gongpu Lan, Salavat Aglyamov, Kirill Larin, Michael D. Twa
Summary: This study evaluated a novel optical coherence tomography (OCT) method for measuring corneal natural frequency in human eyes. The method demonstrated high repeatability and reliability, showing potential for quantitative assessment of corneal biomechanics. Further studies are needed to fully understand its anatomical and structural dependencies.
JOURNAL OF BIOMECHANICS
(2021)
Article
Medicine, General & Internal
Achuth Nair, Manmohan Singh, Salavat R. Aglyamov, Kirill V. Larin
Summary: The biomechanical properties of the cornea are crucial for the health and function of the eye. This study demonstrates the combined use of two elastography techniques to measure corneal stiffness in a live rabbit model, with the ability to detect changes in stiffness after collagen crosslinking.
FRONTIERS IN MEDICINE
(2022)
Article
Optics
Jianjun Yang, Jiansheng Liu, Ting Li, Jingyuan Hu, Jingyi Wang, Yuehan Wu, Shuguo Xie, Xin Zhao, Zheng Zheng
Summary: A dynamic spectroscopic characterization scheme for fast spectral variations based on dual asynchronous under-sampling with triple optical frequency combs is proposed and demonstrated. The scheme shows an increased frequency demodulation range while retaining accuracy and spectral measurement range.
OPTICS AND LASERS IN ENGINEERING
(2022)
Article
Chemistry, Physical
Yulia Alexandrovskaya, Olga Baum, Alexander Sovetsky, Alexander Matveyev, Lev Matveev, Emil Sobol, Vladimir Zaitsev
Summary: This paper presents a new variant of phase-resolved Optical Coherence Elastography (OCE) that enables non-contact visualization of transient local strains in biological tissues and other materials. The capabilities of this technique in studying osmotically-induced strains in cartilaginous tissue impregnated with optical clearing agents (OCA) are demonstrated. The study reveals previously inaccessible details of the complex spatio-temporal evolution of osmotic strains and discusses the effects of different hydrophilic OCAs.
Article
Chemistry, Physical
Asha Parmar, Gargi Sharma, Andreas Ramming, Kanwarpal Singh
Summary: The measurement of skin's biomechanical properties is important for the development of diseases such as skin cancer and systemic sclerosis. Optical coherence elastography (OCE) is an emerging imaging technique for quantitatively characterizing tissue's mechanical properties. Deep skin layers' mechanical properties are more desirable to measure in systemic sclerosis patients. Among the three common methods tested in this study, the pulsed excitation method provides the most reliable measurements in the shortest possible time.
Article
Radiology, Nuclear Medicine & Medical Imaging
Chen Huang, Keren Xie, Yuhan Zhang, Mingchao Li, Songtao Yuan, Qiang Chen
Summary: The proposed fusion method combining SD-OCT and OCTA images is more effective for CNV visualization, providing a satisfying visual effect by integrating complementary information from multimodal images.
Article
Optics
Tanbin Shao, Kecheng Yang, Min Xia, Wenping Guo
Summary: In this study, an enhanced dispersion-encoded full-range spectral interferometry technique is proposed and validated for improving measurement accuracy in samples with significant depth, inclination, and roughness. By removing the direct current and preserving data with good phase continuity, the accuracy of phase compensation is improved. The proposed technique extends the depth measurement range and achieves high axial measurement precision.
Article
Biochemical Research Methods
Yusi Miao, Joseph J. Jing, Zhongping Chen
Summary: Recent advancement in high-speed long-range OCT endoscopy enables tissue compliance characterization, but limited by accurate measurement due to lack of reliable NURD correction method. A robust 2-step NURD correction algorithm was developed and applied in awake human subject to characterize local compliance in nasopharynx for the first time.
BIOMEDICAL OPTICS EXPRESS
(2021)
Article
Oncology
Anton A. A. Plekhanov, Marina A. A. Sirotkina, Ekaterina V. V. Gubarkova, Elena B. B. Kiseleva, Alexander A. A. Sovetsky, Maria M. M. Karabut, Vladimir E. E. Zagainov, Sergey S. S. Kuznetsov, Anna V. V. Maslennikova, Elena V. V. Zagaynova, Vladimir Y. Y. Zaitsev, Natalia D. D. Gladkova
Summary: We demonstrate the use of compression optical coherence elastography (C-OCE) technology to differentiate between cancerous and non-cancerous tissues in the colon and detect their morphological features. By analyzing over fifty tissue samples, we suggest a stiffness threshold value of 520 kPa for detecting colorectal cancer. The C-OCE results show good agreement with histological images, indicating its efficiency in localizing and performing targeted biopsy for colorectal cancer.
FRONTIERS IN ONCOLOGY
(2023)
Article
Chemistry, Analytical
Zhengchuang Lai, Zhongjie Ouyang, Shuncong Zhong, Wei Liang, Xiaoxiang Yang, Jiewen Lin, Qiukun Zhang, Jinlin Li
Summary: Dynamic characteristics of weight sensors play a crucial role in performance evaluation and accurate weight measurements. The study focuses on an optical coherence displacement-based weight sensor, and through numerical simulation and experiments, demonstrates its superior dynamic performance and reduced conditioning time. The study also determines the dynamic performance metrics and enhances the sensor's dynamic performance through design improvements.
Article
Chemistry, Multidisciplinary
Lu Ling, Jeffrey A. Mulligan, Yunxin Ouyang, Adrian A. Shimpi, Rebecca M. Williams, Garrett F. Beeghly, Benjamin D. Hopkins, Jason A. Spector, Steven G. Adie, Claudia Fischbach
ADVANCED FUNCTIONAL MATERIALS
(2020)
Article
Multidisciplinary Sciences
Jeffrey A. Mulligan, Lu Ling, Nichaluk Leartprapun, Claudia Fischbach, Steven G. Adie
Summary: TFM is used to study cellular traction forces, while TF-OCM provides more precise experimental capabilities for 3D collective and dynamic systems, but is mainly used for isolated cells. With computational 4D-OCM methods, we can study the dynamic invasion behavior of large tumor spheroids in collagen.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Analytical
Jungeun Won, Guillermo L. Monroy, Roshan I. Dsouza, Darold R. Spillman, Jonathan McJunkin, Ryan G. Porter, Jindou Shi, Edita Aksamitiene, MaryEllen Sherwood, Lindsay Stiger, Stephen A. Boppart
Summary: Middle ear infection is a common inflammatory disease, with subjective diagnostic methods currently in use. To improve diagnosis, researchers have integrated optical coherence tomography technology into a handheld imaging probe to non-invasively and quantitatively assess middle ear infections.
Article
Biochemical Research Methods
Siyang Liu, Fei Xia, Xusan Yang, Meiqi Wu, Laurie A. Bizimana, Chris Xu, Steven G. Adie
Summary: Optical coherence microscopy uses interferometric detection to capture the complex optical field and computationally corrects aberrations with high sensitivity. By focusing on low-order aberrations, tissue-induced aberrations can be successfully corrected, leading to a significant increase in signal intensity in ex vivo mouse brain tissue.
BIOMEDICAL OPTICS EXPRESS
(2021)
Article
Biochemical Research Methods
Meiqi Wu, Siyang Liu, Nichaluk Leartprapun, Steven Adie
Summary: This work introduces a space/spatial-frequency domain analysis framework for investigating multiple scattering in OCT, and compares the effectiveness of AD-OCT (using astigmatic beams) and standard Gaussian-beam OCT through experiments in scattering tissue phantoms. The study found that increasing astigmatic magnitude can reduce both multiple scattering background and single scattering signal, with the decay in multiple scattering background being larger than in the single scattering signal.
BIOMEDICAL OPTICS EXPRESS
(2021)
Article
Multidisciplinary Sciences
Nichaluk Leartprapun, Steven G. Adie
Summary: This study presents a method to enhance transverse resolution in optical coherence tomography beyond its aberration-free limit by utilizing noise suppression and computational procedures. The resolution enhancement technique demonstrated a 1.5x improvement in resolution while maintaining comparable signal-to-noise ratio in silicone phantom. The technology has the potential to significantly improve visualization of fine microstructural features in various fields, including basic sciences and translational medicine.
SCIENTIFIC REPORTS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Amandeep Singh, Pawan Kumar, Sriya Yeleswarapu, Falguni Pati, Renu John
Summary: The assessment of mechanical stiffness is essential in understanding the biomechanical properties of biological tissues. Surface wave elastography is an emerging technique that quantifies the elastic properties of tissues in clinical diagnosis. In this study, high-speed optical imaging and surface wave elastography were used to characterize the elastic properties of tissue-mimicking phantoms and ex-vivo native caprine liver tissue, showing promising results for future clinical applications.
BIOMEDICAL PHYSICS & ENGINEERING EXPRESS
(2022)
Article
Multidisciplinary Sciences
Yuechuan Lin, Nichaluk Leartprapun, Justin C. Luo, Steven G. Adie
Summary: Quantitative characterization of micro-scale mechanical properties of the extracellular matrix (ECM) and dynamic cell-ECM interactions can significantly enhance fundamental discoveries and their translational potential in the rapidly growing field of mechanobiology. The authors introduce photonic force optical coherence elastography that uses a light-sheet for parallelised and localised mechanical loading. They demonstrate the combination of 3D imaging of extracellular matrix mechanics with cellular-scale resolution and dynamic monitoring of cell-mediated changes.
NATURE COMMUNICATIONS
(2022)
Article
Physics, Applied
Ashwini S. S. Galande, Hanu Phani Ram Gurram, Aruna Priya Kamireddy, Vijaya Sree Venkatapuram, Qurratulain Hasan, Renu John
Summary: Twin image-free phase reconstruction is a challenge in single-shot inline holographic systems. Existing solutions have a trade-off between phase retrieval and twin image elimination. This study proposes a sparsity-assisted iterative phase retrieval approach that achieves high-fidelity phase reconstruction with faster convergence. It shows potential for clinical applications in phase quantification of label-free biological samples.
JOURNAL OF APPLIED PHYSICS
(2022)
Review
Biochemical Research Methods
Nichaluk Leartprapun, Steven G. Adie
Summary: Optical elastography, including optical coherence elastography, Brillouin microscopy, optical microrheology, and photoacoustic elastography, provides a bridge between organ-level medical elastography and single-molecule biophysics. This review discusses the methodologies, recent developments, and integration potential of these techniques with supporting technologies in biomedical fields. By embracing cross-modality and cross-disciplinary interactions, optical elastography can drive new discoveries and advancements in biomedical sciences, facilitating the development of biomechanics-based clinical diagnostics and therapeutics.
BIOMEDICAL OPTICS EXPRESS
(2023)
Article
Physics, Applied
Ashwini S. Galande, Vikas Thapa, Hanu Phani Ram Gurram, Renu John
Summary: Single-shot reconstruction of the inline hologram is achieved using the deep image prior (DIP) method integrated with the regularization by denoising (RED) approach. The use of alternating directions of multipliers method (ADMM) enables a robust single-shot phase recovery by combining DIP and RED. Experimental results demonstrate that sparsity-promoting denoisers outperform DIP in terms of phase signal-to-noise ratio (SNR), with the total variation denoiser being more suitable for hologram reconstruction.
APPLIED PHYSICS LETTERS
(2023)
Article
Materials Science, Biomaterials
Syed Baseeruddin Alvi, P. S. Rajalakshmi, Anil Jogdand, Ambekar Yogeshwari Sanjay, B. Veeresh, Renu John, Aravind Kumar Rengan
Summary: This study investigated a new method for treating acne using liposomal gold nanoparticles entrapping curcumin for light-mediated therapy, which can destroy sebaceous glands and inhibit bacterial growth.
BIOMATERIALS SCIENCE
(2021)
Article
Biochemical Research Methods
Nawab Singh, Azahar Ali, Prabhakar Rai, Inayathullah Ghori, Ashutosh Sharma, B. D. Malhotra, Renu John
Article
Optics
Nichaluk Leartprapun, Yuechuan Lin, Steven G. Adie
Article
Multidisciplinary Sciences
Jeffrey A. Mulligan, Xinzeng Feng, Steven G. Adie
SCIENTIFIC REPORTS
(2019)
