期刊
OPTICS EXPRESS
卷 17, 期 21, 页码 18419-18432出版社
OPTICAL SOC AMER
DOI: 10.1364/OE.17.018419
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- National Science and Engineering Research Council of Canada (NSERC-CHRP)
- Canadian Foundation for Innovation (CFI)
- Canadian Institutes of Health Research (CIHR-CHRP)
- Canadian Institute for Photonics Innovation (CIPI)
The use of coherent anti-Stokes Raman scattering microscopy tuned to the lipid vibration for quantitative myelin imaging suffers from the excitation polarization dependence of this third-order nonlinear optical effect. The contrast obtained depends on the orientation of the myelin membrane, which in turn affects the morphometric parameters that can be extracted with image analysis. We show how circularly polarized laser beams can be used to avoid this complication, leading to images free of excitation polarization dependence. The technique promises to be optimal for in vivo imaging and the resulting images can be used for coherent anti-Stokes Raman scattering optical histology on native state tissue. (c) 2009 Optical Society of America
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