期刊
OPTICS EXPRESS
卷 17, 期 2, 页码 912-923出版社
OPTICAL SOC AMER
DOI: 10.1364/OE.17.000912
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资金
- Ministry of Education, Culture, Sports, Science, and Technology of Japan [19650117, 20240044]
- Cosmetology Research Foundation, Japan
- Grants-in-Aid for Scientific Research [20240044, 19650117] Funding Source: KAKEN
Optical probe methods for in vivo assessments of cutaneous photoaging are necessary in fields such as anti-aging dermatology and skin cosmetic development. We investigated the relation between wrinkle direction and collagen orientation in ultraviolet-B-exposed (UVB-exposed) skin using polarization-resolved second-harmonic-generation (SHG) microscopy. A polarization anisotropic image of the SHG light indicated that wrinkle direction in UVB-exposed skin is predominantly parallel to the orientation of dermal collagen fibers. Furthermore, collagen orientation in post-UVB-exposed skin with few wrinkles changed from that of UVB-exposed wrinkled skin to that of no-UVB-exposed skin. The method proposed has the potential to become a powerful non-invasive tool for assessment of cutaneous photoaging. (C) 2009 Optical Society of America
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